Clin Nutr:六成多的癌症患者存在维生素D缺乏!快来看看该如何补充吧~

2021-06-17 MedSci原创 MedSci原创

维生素D缺乏在白种人癌症患者中非常普遍(66.8%),即使在有补充维生素D的患者中也是如此(31.6%)

维生素D可打击肿瘤相关转化,支持免疫系统的抗癌功能。目前,没有专门针对癌症患者如何补充维生素D的指南。

该研究的主要目的:1)评估维生素D缺乏在白种人癌症患者中的发生率,表征导致个体维生素D浓度降低的临床因素;2)明确可预防癌症患者维生素D缺乏的适宜补充剂量

这项横断面研究纳入了500位明确诊断的白种人肿瘤患者,其中部分患者长期补充维生素D,剂量不一。检测了所有患者的血清维生素D浓度,并从医院数据库中获取相关临床资料。采用适当的统计方法将维生素D缺乏率与临床变量进行关联分析。使用受试者工作特征 (ROC) 曲线估计癌症患者补充维生素D的剂量。

不同维生素D水平的患者数量

一半以上的癌症患者(66.8%)存在维生素D缺乏(≤30 ng/ml);即使是在有补充维生素D的患者中,也有31.6%的患者存在维生素D缺乏症。年长、男性、头颈癌或鳞状细胞癌和体重减轻都是易发生维生素D缺乏症的因素。白种人癌症患者预防维生素D缺乏症的维生素D补充剂量被定为每日 2250 IU

综上,维生素D缺乏在白种人癌症患者中非常普遍(66.8%),即使在有补充维生素D的患者中也是如此(31.6%)。维生素D缺乏症的易感因素有年长、男性、头颈癌或鳞状细胞癌以及体重减轻。癌症患者补充维生素D的剂量应高于普通人群的剂量

补充:补充维生素D的途径有晒太阳、膳食摄入和维生素D补充等途径。但富含维生素D的食物并不多,乳类、蛋黄、动物肝脏(如鱼肝油)和富含脂肪的海鱼(如三文鱼)等含少量维生素D,而植物性食物如谷类、蔬菜和水果几乎不含维生素D。尤其是很多现代人缺乏户外活动、使用防晒产品,都会影响皮肤有效合成维生素D3。因此,不仅是癌症患者,大部分普通人都需要额外补充维生素D。不同国家、不同个体的推荐补充剂量不同。2011年,中华医学会在《原发性骨质症诊治指南》中推荐,普通成年人每日补充200 IU维生素D、老年人每日补充 400~800 IU维生素D。

原始出处:

Kapala Aleksandra,Szlendak Malgorzata,Grochowska Ewelina,Cross-sectional observational study - Investigation of vitamin D concentration in Caucasian cancer patients. what is the adequate dose of vitamin D for these patients?[J] .Clin Nutr, 2021, 40: 3852-3858.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1289718, encodeId=206b1289e18a3, content=<a href='/topic/show?id=cbb8e1356f7' target=_blank style='color:#2F92EE;'>#癌症患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71356, encryptionId=cbb8e1356f7, topicName=癌症患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=10ba218, createdName=zgwhgch, createdTime=Sat Jun 19 08:52:54 CST 2021, time=2021-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=974703, encodeId=03cc9e47037e, content=多晒太阳比较好, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a1105528156, createdName=ms7000000658144288, createdTime=Fri Jun 18 17:34:44 CST 2021, time=2021-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=974566, encodeId=1eab9e456662, content=学习啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=95901993306, createdName=1e1ad8bdm04(暂无匿称), createdTime=Fri Jun 18 07:14:18 CST 2021, time=2021-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=974452, encodeId=41829e445258, content=那就多晒晒太阳<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/1tYkxibUegicBgoiab6uiavY4ODSJI07XdDbH1SlQA5iaY1mSQxkp2TL400VSRq7MPmciaqI1WDC115hwibKnQLc0HI4w/132, createdBy=10df5235438, createdName=香菇不甜, createdTime=Thu Jun 17 19:20:53 CST 2021, time=2021-06-17, status=1, ipAttribution=)]
    2021-06-18 ms7000000658144288

    多晒太阳比较好

    0

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    2021-06-18 1e1ad8bdm04(暂无匿称)

    学习啦

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1289718, encodeId=206b1289e18a3, content=<a href='/topic/show?id=cbb8e1356f7' target=_blank style='color:#2F92EE;'>#癌症患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71356, encryptionId=cbb8e1356f7, topicName=癌症患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=10ba218, createdName=zgwhgch, createdTime=Sat Jun 19 08:52:54 CST 2021, time=2021-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=974703, encodeId=03cc9e47037e, content=多晒太阳比较好, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a1105528156, createdName=ms7000000658144288, createdTime=Fri Jun 18 17:34:44 CST 2021, time=2021-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=974566, encodeId=1eab9e456662, content=学习啦, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=95901993306, createdName=1e1ad8bdm04(暂无匿称), createdTime=Fri Jun 18 07:14:18 CST 2021, time=2021-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=974452, encodeId=41829e445258, content=那就多晒晒太阳<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/1tYkxibUegicBgoiab6uiavY4ODSJI07XdDbH1SlQA5iaY1mSQxkp2TL400VSRq7MPmciaqI1WDC115hwibKnQLc0HI4w/132, createdBy=10df5235438, createdName=香菇不甜, createdTime=Thu Jun 17 19:20:53 CST 2021, time=2021-06-17, status=1, ipAttribution=)]
    2021-06-17 香菇不甜

    那就多晒晒太阳#学习#

    0

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