Diabetes Care:血糖控制与蜂窝织炎风险的关系

2020-12-02 MedSci原创 MedSci原创

血糖控制不佳与蜂窝织炎的发生有关。该研究的结果还表明,口服泼尼松龙治疗会增加患者蜂窝组织炎、肺炎和上呼吸道感染的风险。 

众所周知,糖尿病容易导致常见的感染,例如蜂窝织炎和肺炎。但是,血糖控制水平和感染率之间的相关性尚未明确。近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员分析了大型糖尿病患者队列旨在探究血糖控制与糖尿病患者感染率之间的关系。

在研究期间,研究人员首先为每位患者进行了HbA1c检测,然后在检测后的60天内检索患者的感染诊断。研究人员进行了多元logistic回归分析,以确定HbA1c对被诊断出感染可能性的影响。研究人员能够控制许多混杂因素,例如其他慢性疾病,诊断糖尿病后的时间以及感染前使用类固醇药物。

研究人员确定了407例蜂窝织炎的患者。在HbA1c>7.5%(58 mmol/mol)的患者中,蜂窝组织炎的多因素logistic回归发现风险增加了1.4倍,诸如肥胖、帕金森氏病、周围血管疾病以及先前接受泼尼松治疗等易患蜂窝织炎的因素。HbA1c每升高1%(11 mmol/mol),患者发生蜂窝组织炎的几率就会增加12%(比值比[OR]为1.12;95%CI为1.05-1.19)。类似的分析发现,HbA1c>7.5%(58 mmol/mol;OR为1.1;95%CI为0.9-1.4)的患者发生肺炎的风险呈增加的趋势。

由此可见,血糖控制不佳与蜂窝织炎的发生有关。该研究的结果还表明,口服泼尼松龙治疗会增加患者蜂窝组织炎、肺炎和上呼吸道感染的风险。
 
原始出处:
 
Galia Zacay,et al.Glycemic Control and Risk of Cellulitis.Diabetes care.2020.https://doi.org/10.2337/dc19-1393

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    2021-02-01 6322400001

    学习

    0

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  7. 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encodeId=7fe69043e8a9, content=控制好血糖是关键, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIACOBrWDNwjFKLMc1ooWGuugFdJ3Wz0VveyWdENweVqwYaj2jj8a4BznZxOPFl2U68LpswVHFf6A/132, createdBy=b2035329102, createdName=Tinner , createdTime=Wed Dec 02 20:30:57 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904326, encodeId=652b90432639, content=学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/FqBuslozduJJUzrCctRPPYyDPFfJduQ1Nic9Ts22mr5xjiayJuIXpJ5CHeVZ6z7aUl1VIhIjMKZsDuicqWVPsrQqw/132, createdBy=a6172577695, createdName=小成93, createdTime=Wed Dec 02 15:45:41 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904277, encodeId=08349042e7c0, content=好文章,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Wed Dec 02 12:22:16 CST 2020, time=2020-12-02, status=1, ipAttribution=)]
    2020-12-02 Baodongxu

    前面的二甲双胍回头看看这个

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1820428, encodeId=5ae318204280f, content=<a href='/topic/show?id=c87f10089032' target=_blank style='color:#2F92EE;'>#风险的关系#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100890, encryptionId=c87f10089032, topicName=风险的关系)], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/cc81592b507031e3cfd8d4c57911d98b/62c22832a9474aea1ca90ca058aebc03.jpg, createdBy=bed5446, createdName=limedical1974, createdTime=Wed Jun 16 00:59:12 CST 2021, time=2021-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1902526, encodeId=cd6b190252660, content=<a href='/topic/show?id=c097591ed5' target=_blank style='color:#2F92EE;'>#Diabetes#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5917, 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encodeId=7fe69043e8a9, content=控制好血糖是关键, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIACOBrWDNwjFKLMc1ooWGuugFdJ3Wz0VveyWdENweVqwYaj2jj8a4BznZxOPFl2U68LpswVHFf6A/132, createdBy=b2035329102, createdName=Tinner , createdTime=Wed Dec 02 20:30:57 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904326, encodeId=652b90432639, content=学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/FqBuslozduJJUzrCctRPPYyDPFfJduQ1Nic9Ts22mr5xjiayJuIXpJ5CHeVZ6z7aUl1VIhIjMKZsDuicqWVPsrQqw/132, createdBy=a6172577695, createdName=小成93, createdTime=Wed Dec 02 15:45:41 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904277, encodeId=08349042e7c0, content=好文章,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Wed Dec 02 12:22:16 CST 2020, time=2020-12-02, status=1, ipAttribution=)]
    2020-12-02 Tinner

    控制好血糖是关键

    0

  9. 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encodeId=7fe69043e8a9, content=控制好血糖是关键, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIACOBrWDNwjFKLMc1ooWGuugFdJ3Wz0VveyWdENweVqwYaj2jj8a4BznZxOPFl2U68LpswVHFf6A/132, createdBy=b2035329102, createdName=Tinner , createdTime=Wed Dec 02 20:30:57 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904326, encodeId=652b90432639, content=学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/FqBuslozduJJUzrCctRPPYyDPFfJduQ1Nic9Ts22mr5xjiayJuIXpJ5CHeVZ6z7aUl1VIhIjMKZsDuicqWVPsrQqw/132, createdBy=a6172577695, createdName=小成93, createdTime=Wed Dec 02 15:45:41 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904277, encodeId=08349042e7c0, content=好文章,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Wed Dec 02 12:22:16 CST 2020, time=2020-12-02, status=1, ipAttribution=)]
    2020-12-02 小成93

    学到了

    0

  10. 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encodeId=7fe69043e8a9, content=控制好血糖是关键, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIACOBrWDNwjFKLMc1ooWGuugFdJ3Wz0VveyWdENweVqwYaj2jj8a4BznZxOPFl2U68LpswVHFf6A/132, createdBy=b2035329102, createdName=Tinner , createdTime=Wed Dec 02 20:30:57 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904326, encodeId=652b90432639, content=学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/FqBuslozduJJUzrCctRPPYyDPFfJduQ1Nic9Ts22mr5xjiayJuIXpJ5CHeVZ6z7aUl1VIhIjMKZsDuicqWVPsrQqw/132, createdBy=a6172577695, createdName=小成93, createdTime=Wed Dec 02 15:45:41 CST 2020, time=2020-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904277, encodeId=08349042e7c0, content=好文章,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Wed Dec 02 12:22:16 CST 2020, time=2020-12-02, status=1, ipAttribution=)]
    2020-12-02 yangchou

    好文章,谢谢分享

    0

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JCEM:骨质疏松症与帕金森氏病风险的关系

骨质疏松症与PD风险增加有关,尤其是女性。

Thorax:激素避孕药与重度哮喘加重风险的关系

使用激素避孕药可以降低育龄妇女严重哮喘加重的风险。需要进行机制研究,以探究激素避孕药对女性哮喘临床结局影响的生物学基础。

JCEM:蛋白尿严重程度与成人甲状腺功能减退的风险相关

甲状腺功能低下症在蛋白尿成人中很常见,甲状腺功能低下的风险与蛋白尿严重程度直接相关。

Thorax:夜间轮班工作与哮喘风险增加相关

哮喘和轮班工作具有较高患病率和同时发生,这些结果对公共卫生的影响是深远的。需要进行纵向随访研究,以明确是否修改轮班工作时间表,以减少发生诸如哮喘等炎症性疾病的风险。

Br J Nutr :过犹不及!学者多年研究表明,每天1个鸡蛋,糖尿病风险大增60%

鸡蛋含有丰富的蛋白质、必需脂肪酸、维生素、矿物质、卵磷脂,鸡蛋是最有营养的食品。但是,胆固醇含量也很高,鸡蛋吃多了会堵塞血管,增加心脏病、脑中风和糖尿病的风险。然而,吃鸡蛋和糖尿病之间的联系尚不清楚。