J Thromb Haemost:社会经济状况与静脉血栓栓塞发生风险的关系

2021-09-11 MedSci原创 MedSci原创

高水平的单个SES指标和综合SES评分与VTE风险降低相关。

尽管静脉血栓栓塞(VTE)是发病率和死亡率的主要原因,而且社会经济地位(SES)会影响人类健康及其健康行为,但很少有研究探讨SES与VTE之间的关联。


 
近日,血栓和凝血疾病权威杂志Journal of Thrombosis and Haemostasis上发表了一篇研究文章,研究人员旨在调查根据教育水平、收入和就业状况单独评估和综合评估的SES与VTE事件之间的关联。

研究人员使用丹麦国家登记处确定了51350名25-65岁在1995-2016年期间发生VTE事件的受试者。对于每个病例,研究人员使用发病密度抽样从丹麦一般人群(n=256750)中选择了五个年龄、性别和指数年匹配的对照者。在VTE之前一年和五年评估了SES指标,包括教育、收入和就业状况。在针对年龄、性别和合并症进行调整的分析中,研究人员使用条件Logistic回归根据个体SES指标和综合SES评分计算了VTE的比值比(OR)和95%置信区间(CI)。


与低SES水平相比,高教育水平(OR为0.74;95%CI为0.71-0.77)、高收入(OR为0.70;95%CI为0.68-0.72)和高就业状态(OR为0.66;95%CI为0.64-0.68)是与VTE风险降低相关,即使在调整合并症后也是如此。在评估VTE风险时,综合SES评分优于单个指标(高分与低分相比的OR为:0.61;95%CI为0.59-0.63)。在使用VTE前5年测量的SES指标进行敏感性分析时,风险估计仍然基本相同。
 
由此可见,高水平的单个SES指标和综合SES评分与VTE风险降低相关。

原始出处:
 
Helle Jørgensen.et al.Socioeconomic status and risk of incident venous thromboembolism.Journal of Thrombosis and Haemostasis.2021.https://doi.org/10.1111/jth.15523

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    2022-04-22 fusion
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    2022-07-31 xue8602
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    2022-07-24 changfy
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