J Thromb Haemost:体重指数对静脉血栓栓塞临床结局的影响

2021-09-12 MedSci原创 MedSci原创

体重过轻的VTE患者发生死亡和大出血的风险最高。肥胖VTE患者的死亡风险低于BMI正常的VTE患者。

关于体重指数(BMI)对静脉血栓栓塞(VTE)患者临床结局影响的信息较为有限。近日,血栓和凝血疾病权威杂志Journal of Thrombosis and Haemostasis上发表了一篇研究文章,该研究旨在调查BMI对VTE患者的基线特征、治疗模式和24个月结局的影响。


 GARFIELD-VTE是一项前瞻性、非干预性研究,纳入了10869名经客观确诊的VTE患者。患者根据BMI分组:<18.5(体重较低;n=214);18.5-24.9(正常;n=2866);25.0-29.9(超重;n=3326);≥30(肥胖;n=3073)。

与BMI正常的患者相比,肥胖患者更多为白种人(77.4% vs. 57.9%),在门诊接受治疗(30.4% vs. 23.1%),并且既往有VTE(17.5% vs. 11.7%)。活动性癌症与较低的BMI相关(体重不足:30.4%,正常:13.5%,超重:9.4%,肥胖:7.0%)。在基线时,与体重较低或体重指数正常的患者(30.8%和21.6%)相比,超重和肥胖患者接受单独肠外治疗的频率较低(16.7%和14.4%)。

与BMI正常的患者相比,肥胖患者更常服用抗凝剂≥2年(52.3% vs. 37.7%)。24个月后,超重和肥胖患者的全因死亡风险低于BMI正常的患者(调整后的风险比[95%CI]分别为0.75[0.63-0.89]和0.59[0.49-0.72]))。与体重指数正常的患者相比,体重较低的患者更常发生大出血(2.45[1.41-4.26])和全因死亡率(1.90[1.43-2.53])。复发性VTE在各组之间相当。
 
由此可见,体重过轻的VTE患者发生死亡和大出血的风险最高。肥胖VTE患者的死亡风险低于BMI正常的VTE患者。

原始出处:
 
Jeffrey I. Weitz.et al.Influence of Body Mass Index on Clinical Outcomes in Venous Thromboembolism: Insights from GARFIELD-VTE.Journal of Thrombosis and Haemostasis.2021.https://onlinelibrary.wiley.com/doi/10.1111/jth.15520

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    2022-07-03 147e6498m18暂无昵称

    产妇体重指数体重指数如何计算?

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    2022-07-03 147e6498m18暂无昵称

    卧床病人的体重指数如何计算呢

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    2022-05-27 changfy
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    2022-04-19 xue8602
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    2021-09-13 ms1000002136354097

    谢谢了

    0

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    2021-09-12 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

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