J Sex Med:后非那雄胺综合征患者的差异性基因表达

2021-07-27 AlexYang MedSci原创

由使用5-α还原酶抑制剂(5ARIs)的后非那雄胺综合征男性报告的一系列持续的性功能、神经精神和身体症状,其有机病因到目前尚有争议。有研究人员认为神经类固醇水平或雄性激素受体表达的持续变化

由使用5-α还原酶抑制剂(5ARIs)的后非那雄胺综合征男性报告的一系列持续的性功能、神经精神和身体症状,其有机病因到目前尚有争议。有研究人员认为神经类固醇水平或雄性激素受体表达的持续变化与此有关。

近期,有研究人员确定了报告具有后非那雄胺综合征症状的患者与健康对照组之间是否存在基因表达的差异,尤其是相关生物途径的差异

研究是一项单中心、前瞻性病例对照研究,在2013年3月至2018年9月进行。纳入了18岁及以上正在接受性功能障碍(研究)或包皮环切术(对照)评估的男性。26名有5ARI使用史的男性纳入患者组,其报告的症状与后非那雄胺综合征一致。26名男性同意纳入对照组。

研究人员将研究组26名中位年龄为38岁(IQR,33-42)男性的阴茎皮肤样本的基因表达与对照组26名中位年龄为41岁(IQR,35-62)男性的基因表达进行了比较(P=0.13),结果发现,患者组有1446个基因明显过表达,2318个基因明显表达下调。与对照组相比,患者组的雄激素受体表达量明显更高(9.961 vs 9.494,调整后的P=0.01)。雄性激素受体活性标志物5α-雄性烷二醇(0.950纳克/毫升[0.749-1.587] vs 0.949[0.817-1.337],P=0.34)或3α-雄性烷二酮(3.1纳克/毫升[1.925-5.475] vs 6.7[3.375-11.4] ,P=0.31)的血清水平没有发现明显差异。三核苷酸重复数(21.5 [20-23.75], 22 [19-25], P=0.94)之间也没有发现明显差异。

前20个过表达基因情况

综上所述,他们的研究是第一个考虑并证明PFS患者的基因表达差异是性功能障碍的潜在病因。在这项研究中,他们提出了基因表达与后非那雄胺综合征患者的生物学差异相关的证据;开具5ARIs的医疗机构应注意并向患者提供相应的建议。

原始出处:

Skyler Howell, Weitao Song, Alexander Pastuszak et al. Differential Gene Expression in Post-Finasteride Syndrome Patients. J Sex Med. Jul 2021

 

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    2021-11-16 何五7

    这是个灾难,我就是非那雄胺综合征受害者

    0

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    2021-07-29 zhouqu_8
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    2021-07-27 1def62fbm10(暂无匿称)

    非常好

    0

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