JAHA:血钾校正对伴有高钾血症的高血压患者短期死亡率的影响

2020-12-03 MedSci原创 MedSci原创

高钾血症过度校正(<4.1 mmol/L)与全因和心血管疾病死亡率增加相关。血钾>5.5mmol/L也与全因和心血管疾病死亡率增加有关。

高钾血症具有极大危害,但对纠正高钾血症的效果却鲜有研究。近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员使用全国范围的数据评估了高血压患者的高钾血症的情况。

研究人员确定了7620例高血压患者,他们在开始联合降压治疗的100天内首次测定血钾≥4.7 mmol/L(高钾血症)。研究人员对受试者高钾血症诊断后6至100天进行了第二次血钾测量。研究人员使用Cox回归评估了第二次血钾水平与受试者90天内的全因死亡率之间的关系,并评估了第二次血钾测量值预先设定的8个血钾水平对应的死亡率:2.2至2.9 mmol/L(n=37)、3.0至3.4 mmol/L(n=184)、3.5至3.7 mmol/L(n=325)、 3.8至4.0 mmol/L(n=791)、4.1至4.6 mmol/L(n=3533,对照组)、4.7至5.0 mmol/L(n=1786)、5.1至5.5 mmol/L(n=720)和5.6至7.8mmol/L(n=244)。

8个血钾水平组个体90天死亡率分别为37.8%、21.2%、14.5%、9.6%、6.3%、6.2%、10.0%和16.4%。多变量分析显示,高钾血症发生后浓度>5.5 mmol/L的患者与对照组相比有更高的死亡风险(风险比[HR]为2.27;95%CI为1.60–3.20;P<0.001)。

与对照组相比,血钾水平为3.5至3.7 mmol/L和3.8至4.0mmol/L也与死亡风险增加相关(HR为1.71;95%CI为1.23–2.37;P<0.001;HR为1.36;95%CI为1.04– 1.76;P<0.001)。研究人员观察到血钾水平在5.1至5.5 mmol/L范围时死亡风险呈增加趋势(HR为1.29; 95%CI为0.98-1.69)。血钾<4.1 mmol/L和>5.0 mmol/L与心血管死亡风险增加相关。

由此可见,高钾血症过度校正(<4.1 mmol/L)与全因和心血管疾病死亡率增加相关。血钾>5.5mmol/L也与全因和心血管疾病死亡率增加有关。

在线使用:中国慢性肾病患者高血钾风险预测模型

原始出处:

Masahiro Takahata.et al.Impact of Plasma Potassium Normalization on Short‐Term Mortality in Patients With Hypertension and Hyperkalemia.J AM HEART ASSOC.2020.https://www.ahajournals.org/doi/full/10.1161/JAHA.120.017087

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1057079, encodeId=2284105e079f6, content=实验设计的不够合理。难道没有考虑到高钾血症复发的情况吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=c7cf5413645, createdName=ms3000000975027679, createdTime=Sun Oct 03 11:05:41 CST 2021, time=2021-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=905165, encodeId=a21e9051658c, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/ajNVdqHZLLC9x0gEE3vPgfxFhP8DuPbQ3yQ0xGXicqYuicn9LkMlzms3U0ZbxCu7L9icx1L736nicyYVfXfW5DztXg/132, createdBy=d8a82043360, createdName=noasking, createdTime=Sat Dec 05 12:03:35 CST 2020, time=2020-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268370, encodeId=3f1912683e0ed, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sat Dec 05 06:21:12 CST 2020, time=2020-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1448323, encodeId=1ef51448323bd, content=<a href='/topic/show?id=5a9c102681f2' target=_blank style='color:#2F92EE;'>#高血压患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102681, encryptionId=5a9c102681f2, topicName=高血压患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b4665409655, createdName=维他命, createdTime=Sat Dec 05 06:21:12 CST 2020, time=2020-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1514536, encodeId=1a7f15145369e, content=<a href='/topic/show?id=102f102e8375' target=_blank style='color:#2F92EE;'>#高钾#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102783, encryptionId=102f102e8375, topicName=高钾)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c5d010658633, createdName=ms7517674339485982, createdTime=Sat Dec 05 06:21:12 CST 2020, time=2020-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904772, encodeId=5168904e728f, content=学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201126/cd191656b97f470781c0bd36448d9422/aa9a30b60c6646ad94bf6f39648feb47.jpg, createdBy=58b01524016, createdName=355366180, createdTime=Fri Dec 04 09:51:08 CST 2020, time=2020-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904648, encodeId=192b90464847, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=76f35437230, createdName=ms3000000809697575, createdTime=Thu Dec 03 17:54:57 CST 2020, time=2020-12-03, status=1, ipAttribution=)]
    2021-10-03 ms3000000975027679

    实验设计的不够合理。难道没有考虑到高钾血症复发的情况吗

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1057079, encodeId=2284105e079f6, content=实验设计的不够合理。难道没有考虑到高钾血症复发的情况吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=c7cf5413645, createdName=ms3000000975027679, createdTime=Sun Oct 03 11:05:41 CST 2021, time=2021-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=905165, encodeId=a21e9051658c, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/ajNVdqHZLLC9x0gEE3vPgfxFhP8DuPbQ3yQ0xGXicqYuicn9LkMlzms3U0ZbxCu7L9icx1L736nicyYVfXfW5DztXg/132, createdBy=d8a82043360, createdName=noasking, createdTime=Sat Dec 05 12:03:35 CST 2020, time=2020-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268370, encodeId=3f1912683e0ed, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sat Dec 05 06:21:12 CST 2020, time=2020-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1448323, encodeId=1ef51448323bd, content=<a href='/topic/show?id=5a9c102681f2' target=_blank style='color:#2F92EE;'>#高血压患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102681, encryptionId=5a9c102681f2, topicName=高血压患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b4665409655, createdName=维他命, createdTime=Sat Dec 05 06:21:12 CST 2020, time=2020-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1514536, encodeId=1a7f15145369e, content=<a href='/topic/show?id=102f102e8375' target=_blank style='color:#2F92EE;'>#高钾#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102783, encryptionId=102f102e8375, topicName=高钾)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c5d010658633, createdName=ms7517674339485982, createdTime=Sat Dec 05 06:21:12 CST 2020, time=2020-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904772, encodeId=5168904e728f, content=学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201126/cd191656b97f470781c0bd36448d9422/aa9a30b60c6646ad94bf6f39648feb47.jpg, createdBy=58b01524016, createdName=355366180, createdTime=Fri Dec 04 09:51:08 CST 2020, time=2020-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904648, encodeId=192b90464847, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=76f35437230, createdName=ms3000000809697575, createdTime=Thu Dec 03 17:54:57 CST 2020, time=2020-12-03, status=1, ipAttribution=)]
    2020-12-05 noasking

    学习了

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1057079, encodeId=2284105e079f6, content=实验设计的不够合理。难道没有考虑到高钾血症复发的情况吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=c7cf5413645, createdName=ms3000000975027679, createdTime=Sun Oct 03 11:05:41 CST 2021, time=2021-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=905165, encodeId=a21e9051658c, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/ajNVdqHZLLC9x0gEE3vPgfxFhP8DuPbQ3yQ0xGXicqYuicn9LkMlzms3U0ZbxCu7L9icx1L736nicyYVfXfW5DztXg/132, createdBy=d8a82043360, createdName=noasking, createdTime=Sat Dec 05 12:03:35 CST 2020, time=2020-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268370, encodeId=3f1912683e0ed, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sat Dec 05 06:21:12 CST 2020, time=2020-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1448323, encodeId=1ef51448323bd, content=<a href='/topic/show?id=5a9c102681f2' target=_blank style='color:#2F92EE;'>#高血压患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102681, encryptionId=5a9c102681f2, topicName=高血压患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b4665409655, createdName=维他命, createdTime=Sat Dec 05 06:21:12 CST 2020, time=2020-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1514536, encodeId=1a7f15145369e, content=<a href='/topic/show?id=102f102e8375' target=_blank style='color:#2F92EE;'>#高钾#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102783, encryptionId=102f102e8375, topicName=高钾)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c5d010658633, createdName=ms7517674339485982, createdTime=Sat Dec 05 06:21:12 CST 2020, time=2020-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904772, encodeId=5168904e728f, content=学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201126/cd191656b97f470781c0bd36448d9422/aa9a30b60c6646ad94bf6f39648feb47.jpg, createdBy=58b01524016, createdName=355366180, createdTime=Fri Dec 04 09:51:08 CST 2020, time=2020-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904648, encodeId=192b90464847, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=76f35437230, createdName=ms3000000809697575, createdTime=Thu Dec 03 17:54:57 CST 2020, time=2020-12-03, status=1, ipAttribution=)]
    2020-12-05 zhaohui6731
  4. [GetPortalCommentsPageByObjectIdResponse(id=1057079, encodeId=2284105e079f6, content=实验设计的不够合理。难道没有考虑到高钾血症复发的情况吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=c7cf5413645, createdName=ms3000000975027679, createdTime=Sun Oct 03 11:05:41 CST 2021, time=2021-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=905165, encodeId=a21e9051658c, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/ajNVdqHZLLC9x0gEE3vPgfxFhP8DuPbQ3yQ0xGXicqYuicn9LkMlzms3U0ZbxCu7L9icx1L736nicyYVfXfW5DztXg/132, createdBy=d8a82043360, createdName=noasking, createdTime=Sat Dec 05 12:03:35 CST 2020, time=2020-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268370, encodeId=3f1912683e0ed, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sat Dec 05 06:21:12 CST 2020, time=2020-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1448323, encodeId=1ef51448323bd, content=<a href='/topic/show?id=5a9c102681f2' target=_blank style='color:#2F92EE;'>#高血压患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102681, encryptionId=5a9c102681f2, topicName=高血压患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b4665409655, createdName=维他命, createdTime=Sat Dec 05 06:21:12 CST 2020, time=2020-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1514536, encodeId=1a7f15145369e, content=<a href='/topic/show?id=102f102e8375' target=_blank style='color:#2F92EE;'>#高钾#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102783, encryptionId=102f102e8375, topicName=高钾)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c5d010658633, createdName=ms7517674339485982, createdTime=Sat Dec 05 06:21:12 CST 2020, time=2020-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904772, encodeId=5168904e728f, content=学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201126/cd191656b97f470781c0bd36448d9422/aa9a30b60c6646ad94bf6f39648feb47.jpg, createdBy=58b01524016, createdName=355366180, createdTime=Fri Dec 04 09:51:08 CST 2020, time=2020-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904648, encodeId=192b90464847, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=76f35437230, createdName=ms3000000809697575, createdTime=Thu Dec 03 17:54:57 CST 2020, time=2020-12-03, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1057079, encodeId=2284105e079f6, content=实验设计的不够合理。难道没有考虑到高钾血症复发的情况吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=c7cf5413645, createdName=ms3000000975027679, createdTime=Sun Oct 03 11:05:41 CST 2021, time=2021-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=905165, encodeId=a21e9051658c, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/ajNVdqHZLLC9x0gEE3vPgfxFhP8DuPbQ3yQ0xGXicqYuicn9LkMlzms3U0ZbxCu7L9icx1L736nicyYVfXfW5DztXg/132, createdBy=d8a82043360, createdName=noasking, createdTime=Sat Dec 05 12:03:35 CST 2020, time=2020-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268370, encodeId=3f1912683e0ed, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sat Dec 05 06:21:12 CST 2020, time=2020-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1448323, encodeId=1ef51448323bd, content=<a href='/topic/show?id=5a9c102681f2' target=_blank style='color:#2F92EE;'>#高血压患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102681, encryptionId=5a9c102681f2, topicName=高血压患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b4665409655, createdName=维他命, createdTime=Sat Dec 05 06:21:12 CST 2020, time=2020-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1514536, encodeId=1a7f15145369e, content=<a href='/topic/show?id=102f102e8375' target=_blank style='color:#2F92EE;'>#高钾#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102783, encryptionId=102f102e8375, topicName=高钾)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c5d010658633, createdName=ms7517674339485982, createdTime=Sat Dec 05 06:21:12 CST 2020, time=2020-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904772, encodeId=5168904e728f, content=学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201126/cd191656b97f470781c0bd36448d9422/aa9a30b60c6646ad94bf6f39648feb47.jpg, createdBy=58b01524016, createdName=355366180, createdTime=Fri Dec 04 09:51:08 CST 2020, time=2020-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904648, encodeId=192b90464847, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=76f35437230, createdName=ms3000000809697575, createdTime=Thu Dec 03 17:54:57 CST 2020, time=2020-12-03, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1057079, encodeId=2284105e079f6, content=实验设计的不够合理。难道没有考虑到高钾血症复发的情况吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=c7cf5413645, createdName=ms3000000975027679, createdTime=Sun Oct 03 11:05:41 CST 2021, time=2021-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=905165, encodeId=a21e9051658c, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/ajNVdqHZLLC9x0gEE3vPgfxFhP8DuPbQ3yQ0xGXicqYuicn9LkMlzms3U0ZbxCu7L9icx1L736nicyYVfXfW5DztXg/132, createdBy=d8a82043360, createdName=noasking, createdTime=Sat Dec 05 12:03:35 CST 2020, time=2020-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268370, encodeId=3f1912683e0ed, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sat Dec 05 06:21:12 CST 2020, time=2020-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1448323, encodeId=1ef51448323bd, content=<a href='/topic/show?id=5a9c102681f2' target=_blank style='color:#2F92EE;'>#高血压患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102681, encryptionId=5a9c102681f2, topicName=高血压患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b4665409655, createdName=维他命, createdTime=Sat Dec 05 06:21:12 CST 2020, time=2020-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1514536, encodeId=1a7f15145369e, content=<a href='/topic/show?id=102f102e8375' target=_blank style='color:#2F92EE;'>#高钾#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102783, encryptionId=102f102e8375, topicName=高钾)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c5d010658633, createdName=ms7517674339485982, createdTime=Sat Dec 05 06:21:12 CST 2020, time=2020-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904772, encodeId=5168904e728f, content=学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201126/cd191656b97f470781c0bd36448d9422/aa9a30b60c6646ad94bf6f39648feb47.jpg, createdBy=58b01524016, createdName=355366180, createdTime=Fri Dec 04 09:51:08 CST 2020, time=2020-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904648, encodeId=192b90464847, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=76f35437230, createdName=ms3000000809697575, createdTime=Thu Dec 03 17:54:57 CST 2020, time=2020-12-03, status=1, ipAttribution=)]
    2020-12-04 355366180

    学习了。

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1057079, encodeId=2284105e079f6, content=实验设计的不够合理。难道没有考虑到高钾血症复发的情况吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=c7cf5413645, createdName=ms3000000975027679, createdTime=Sun Oct 03 11:05:41 CST 2021, time=2021-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=905165, encodeId=a21e9051658c, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/ajNVdqHZLLC9x0gEE3vPgfxFhP8DuPbQ3yQ0xGXicqYuicn9LkMlzms3U0ZbxCu7L9icx1L736nicyYVfXfW5DztXg/132, createdBy=d8a82043360, createdName=noasking, createdTime=Sat Dec 05 12:03:35 CST 2020, time=2020-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268370, encodeId=3f1912683e0ed, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sat Dec 05 06:21:12 CST 2020, time=2020-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1448323, encodeId=1ef51448323bd, content=<a href='/topic/show?id=5a9c102681f2' target=_blank style='color:#2F92EE;'>#高血压患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102681, encryptionId=5a9c102681f2, topicName=高血压患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b4665409655, createdName=维他命, createdTime=Sat Dec 05 06:21:12 CST 2020, time=2020-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1514536, encodeId=1a7f15145369e, content=<a href='/topic/show?id=102f102e8375' target=_blank style='color:#2F92EE;'>#高钾#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102783, encryptionId=102f102e8375, topicName=高钾)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c5d010658633, createdName=ms7517674339485982, createdTime=Sat Dec 05 06:21:12 CST 2020, time=2020-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904772, encodeId=5168904e728f, content=学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201126/cd191656b97f470781c0bd36448d9422/aa9a30b60c6646ad94bf6f39648feb47.jpg, createdBy=58b01524016, createdName=355366180, createdTime=Fri Dec 04 09:51:08 CST 2020, time=2020-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=904648, encodeId=192b90464847, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=76f35437230, createdName=ms3000000809697575, createdTime=Thu Dec 03 17:54:57 CST 2020, time=2020-12-03, status=1, ipAttribution=)]
    2020-12-03 ms3000000809697575

    学习了

    0

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