Lancet Diabetes Endocrinol:全球儿童/青少年甲状腺癌的发病率变化趋势

2021-01-23 MedSci原创 MedSci原创

全球儿童青少年的甲状腺癌发病率也在年年长?

在过去的三十年里,多个国家的成年人甲状腺癌发病率有相当大幅度的增长,这主要归因于过度诊断。鉴于成人甲状腺癌发病率的增加,本研究旨在评估甲状腺癌在儿童和青少年中的发病率和死亡率的全球模式和趋势。

研究人员筛选了国际儿童癌症第3卷研究数据库、世界卫生组织死亡率数据库和五大洲癌症发病率数据库的数据,对0-19岁儿童和青少年甲状腺癌的发病率和死亡率进行了基于人群的研究,分析了发病率的时间变化趋势,包括发病率的绝对变化,以及儿童和青少年发病率与成人发病率之间的相关性。

2008年-2012年,0-19岁儿童和青少年的甲状腺癌年龄标准化的发病率从0.4例/100万人年(乌干达和肯尼亚)到13.4例/100万人年(白俄罗斯)不等。发病率的差异主要是由乳头状甲状腺癌亚型引起的。无论是男生还是女生,发病率都随着年龄的增长而增加;而且,女生的发病率几乎总是高于男生。在1998-2002年和2008-2012年间,几乎所有国家的发病率都迅速增加。儿童和青少年的国家发病率与成人发病率有很强的相关性(r<0.8),发病率的时间变化也是如此(r>0.6)。每个国家的20岁以下死于甲状腺癌的人数都低于0.1人/1000万人年。

综上,儿童和青少年甲状腺癌的发病率模式与成人的发病模式一致,这提示过度诊断在其中可能也起着重要作用,而过度诊断反过来又可能会导致过度治疗、终生医疗和副作用,从而对生活质量产生负面影响

原始出处:

Vaccarella Salvatore,Lortet-Tieulent Joannie,Colombet Murielle et al. Global patterns and trends in incidence and mortality of thyroid cancer in children and adolescents: a population-based study. Lancet Diabetes Endocrinol, 2021, 10.1016/S2213-8587(20)30401-0.

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    2021-04-09 howi
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    2021-01-24 1e1fd1c9m05(暂无匿称)

    过度诊断后理性对待吧。

    0

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    2021-01-24 goodbing

    顶刊就是不一样,质量很高,内容精彩!学到很多

    0

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