Photodiagnosis Photodyn Ther:局部抗病毒疗法联合抗菌光动力疗法能更有效的治疗儿童疱疹性龈口炎

2022-09-19 MedSci原创 MedSci原创

近日,发表于Photodiagnosis Photodyn Ther的一项临床研究评估了抗菌光动力疗法(aPDT)作为局部抗病毒治疗的辅助治疗手段,治疗儿童疱疹性龈口炎的效果。

近日,发表于Photodiagnosis Photodyn Ther的一项临床研究评估了抗菌光动力疗法(aPDT)作为局部抗病毒治疗的辅助治疗手段,治疗儿童疱疹性龈口炎的效果。

研究共纳入了45名疱疹性龈口炎(HG)儿童患者(年龄组为12-18岁),根据提供的治疗方法分为三组:(a) A组:局部抗病毒治疗(TAT)(n = 14,平均年龄=17.0岁)(b) B组:抗菌光动力治疗(aPDT)(n = 15,平均年龄=17.7岁)和(c) C组:局部抗病毒治疗+辅助aPDT(n = 16,平均年龄=18.0岁)。评估了疼痛评分[视觉模拟量表(VAS)和麦吉尔疼痛问卷(MPQ)],并对HSV-1进行了量化。使用酶联免疫吸附试验(ELISA)来评估促炎症细胞因子的水平,包括白细胞介素6(IL-6)和肿瘤坏死因子-α(TNF-α)。使用Mann-Whitney检验来计算平均值和进行组间比较。使用弗里德曼检验确定HSV定量、疼痛评分和促炎症细胞因子的变化。使用方差分析来量化随访时观察到的差异。分别在基线、术后即刻、两周和四周、三个月和六个月进行临床试验的评估。

 

结果显示,根据临床评估后获得的数据分析,三组报告的疼痛评分、HSV-1定量和促炎症细胞因子的水平都有所下降。然而,C组(TAT + aPDT)报告了观察到的参数的改善,与A组(TAT)和B组(aPDT)相比均具有统计学意义。

综上所述,该研究结果表明,抗菌光动力疗法(aPDT)与局部抗病毒疗法(TAT)相结合,有助于降低儿童疱疹性龈口炎的疼痛评分和促炎症细胞因子水平。

 

原始出处:

 

Sajith Vellappally, et al., Efficacy of antimicrobial photodynamic therapy versus antiviral therapy in the treatment of herpetic gingivostomatitis among children: Aa randomized controlled clinical trial. Photodiagnosis Photodyn Ther. 2022 Sep;39:102895. doi: 10.1016/j.pdpdt.2022.102895.

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    2023-05-10 liuxiaona
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  5. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546348, encodeId=088a154634842, content=<a href='/topic/show?id=0da528e33ce' target=_blank style='color:#2F92EE;'>#光动力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28733, encryptionId=0da528e33ce, topicName=光动力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b6213920685, createdName=luckyshitiancai_42705688, createdTime=Mon Sep 19 01:56:41 CST 2022, time=2022-09-19, status=1, ipAttribution=)]
    2022-09-20 ms1000001662327619

    学到了

    0

  6. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546348, encodeId=088a154634842, content=<a href='/topic/show?id=0da528e33ce' target=_blank style='color:#2F92EE;'>#光动力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28733, encryptionId=0da528e33ce, topicName=光动力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b6213920685, createdName=luckyshitiancai_42705688, createdTime=Mon Sep 19 01:56:41 CST 2022, time=2022-09-19, status=1, ipAttribution=)]
    2022-09-19 yahu
  7. 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  8. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546348, encodeId=088a154634842, content=<a href='/topic/show?id=0da528e33ce' target=_blank style='color:#2F92EE;'>#光动力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28733, encryptionId=0da528e33ce, topicName=光动力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b6213920685, createdName=luckyshitiancai_42705688, createdTime=Mon Sep 19 01:56:41 CST 2022, time=2022-09-19, status=1, ipAttribution=)]
    2022-09-19 chg122
  9. 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