Diabetes:低血浆脂联素与2型糖尿病风险的关系

2021-08-31 MedSci原创 MedSci原创

低血浆脂联素与2型糖尿病风险增加相关,这种关联可能为因果关系。

近日,糖尿病领域权威杂志Diabetes上发表了一篇研究文章,研究人员旨在检验以下假设:即低血浆脂联素水平与2型糖尿病风险增加之间存在因果关系。

观察分析容易出现混淆和反向因果关系,而遗传孟德尔随机化分析受这些偏倚的影响要小得多。研究人员通过观察性分析评估了30045名哥本哈根人(1751名2型糖尿病患者;血浆脂联素),使用单样本孟德尔随机化分析了96903名哥本哈根人(5012名2型糖尿病患者;五种遗传变异),以及通过使用两样本孟德尔随机化分析了659316名欧洲人(ADIPOGen、GERA、DIAGRAM和UKBiobank)(62892名2型糖尿病患者;十种遗传变异)。

从观察性分析上看,与血浆脂联素中位数为28.9μg/mL(第4个四分位数)的个体相比,19.2μg/mL(第3个四分位数)的个体患2型糖尿病的多变量调整风险比为1.42(95%CI:1.18-1.72),13.9μg/mL(第2个四分位数)的个体为2.21(1.84-2.66),9.2μg/mL(第1个四分位数)的个体为4.05(3.38-4.86)。70岁时相应的2型糖尿病累积发病率分别为3%、7%、11%和20%。

血浆脂联素每降低1μg/mL,发生2型糖尿病的风险比为1.07(1.06-1.09),而在单样本孟德尔随机化模型中,血浆脂联素浓度对数转换每降低1单位的遗传、因果风险比为1.13(0.83-1.53​​),在两样本孟德尔随机化中为1.26(1.01-1.57)。

总之,低血浆脂联素与2型糖尿病风险增加相关,这种关联可能为因果关系。

原始出处:

Maria B. Nielsen,et al.Low Plasma Adiponectin in Risk of Type 2 Diabetes: Observational Analysis and One- and Two-Sample Mendelian Randomization Analyses in 756,219 Individuals.Diabetes.2021.https://doi.org/10.2337/db21-0131

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