Radiat Oncol:低水平激光治疗化疗引起的头颈部肿瘤粘膜炎

2020-06-22 MedSci原创 MedSci原创

低水平激光治疗(LLLT)又称光生物调控治疗(PBMT),可以降低头颈部癌症患者接受化学放疗的口腔黏膜炎(OM)的发生率和严重程度,但目前还缺少有关疗效和安全性的随机数据,治疗剂量为4J/cm2。

低水平激光治疗(LLLT)又称光生物调控治疗(PBMT),可以降低头颈部癌症患者接受化学放疗的口腔黏膜炎(OM)的发生率和严重程度,但目前还缺少有关疗效和安全性的随机数据,治疗剂量为4J/cm2。

 

该III期试验在口腔癌、口咽癌(III期或IV期)患者中进行。患者在化放疗期间,对OM病灶等级≥2级(4 J/cm2或安慰剂)进行激光治疗,直至康复。OM的严重程度(≥3级的发生率和持续时间)作为主要终点,并进行盲法评估。

 

结果,在97名随机患者中,83名患者(85.6%)可以最终评估,32名患者因OM病灶无法到达而没有进行激光治疗。LLLT/PBMT两组的随机化和人群特征(性别比、年龄、化放疗程序、毒物发生率)仍具有可比性。41名患者(49.4%)观察到急性OM(等级≥3级):主动激光组23名患者(54.8%)与对照组18名患者(43.9%)(修正打算治疗,p=0.32)。半数患者发生OM≥3级前的中位时间,主动激光组为8周(对照组为9周)。然而,95%的患者对LLLT/PBMT表现出非常好的耐受性。

 

总之,该研究根据多国癌症辅助治疗协会的建议对LLLT/PBMT进行了评估,但缺乏动力。LLLT/PBMT耐受性好,安全性好,促进其在临床常规中用于重症OM治疗。

 

原始出处:

 

Florence Legouté, René-Jean Bensadoun, et al., Low-level Laser Therapy in Treatment of Chemoradiotherapy-Induced Mucositis in Head and Neck Cancer: Results of a Randomised, Triple Blind, Multicentre Phase III Trial. Radiat Oncol. 2019 May 22;14(1):83. doi: 10.1186/s13014-019-1292-2.

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05:04:23 CST 2020, time=2020-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038052, encodeId=d1d2103805222, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Mon Jun 22 17:04:23 CST 2020, time=2020-06-22, status=1, ipAttribution=)]
    2021-06-02 imp_xiaoww

    对其他部位粘膜炎有效吗

    0

  2. 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    2020-06-26 minlingfeng
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05:04:23 CST 2020, time=2020-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038052, encodeId=d1d2103805222, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Mon Jun 22 17:04:23 CST 2020, time=2020-06-22, status=1, ipAttribution=)]
    2021-02-22 hyf028
  4. 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topicList=[TopicDto(id=66750, encryptionId=265c66e50ea, topicName=激光)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4fd6156, createdName=oliver169, createdTime=Wed Jun 24 05:04:23 CST 2020, time=2020-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1434728, encodeId=2bbd1434e281f, content=<a href='/topic/show?id=817f66e686a' target=_blank style='color:#2F92EE;'>#激光治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66768, encryptionId=817f66e686a, topicName=激光治疗)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Jun 24 05:04:23 CST 2020, time=2020-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491863, encodeId=685f14918633b, content=<a href='/topic/show?id=b4f14442346' target=_blank style='color:#2F92EE;'>#头颈部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44423, encryptionId=b4f14442346, topicName=头颈部)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0b2d8903151, createdName=wshxjq, createdTime=Wed Jun 24 05:04:23 CST 2020, time=2020-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1589830, encodeId=101115898301f, content=<a href='/topic/show?id=124d10065220' target=_blank style='color:#2F92EE;'>#颈部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100652, encryptionId=124d10065220, topicName=颈部)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c46a17776631, createdName=木头人519, createdTime=Wed Jun 24 05:04:23 CST 2020, time=2020-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038052, encodeId=d1d2103805222, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Mon Jun 22 17:04:23 CST 2020, time=2020-06-22, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=970330, encodeId=c4259e03302f, content=对其他部位粘膜炎有效吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=1ef41537097, createdName=imp_xiaoww, createdTime=Wed Jun 02 13:22:52 CST 2021, time=2021-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1865852, encodeId=ad661865852c7, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Fri Jun 26 09:04:23 CST 2020, time=2020-06-26, status=1, 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topicList=[TopicDto(id=66750, encryptionId=265c66e50ea, topicName=激光)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4fd6156, createdName=oliver169, createdTime=Wed Jun 24 05:04:23 CST 2020, time=2020-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1434728, encodeId=2bbd1434e281f, content=<a href='/topic/show?id=817f66e686a' target=_blank style='color:#2F92EE;'>#激光治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66768, encryptionId=817f66e686a, topicName=激光治疗)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Jun 24 05:04:23 CST 2020, time=2020-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491863, encodeId=685f14918633b, content=<a href='/topic/show?id=b4f14442346' target=_blank style='color:#2F92EE;'>#头颈部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44423, encryptionId=b4f14442346, topicName=头颈部)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0b2d8903151, createdName=wshxjq, createdTime=Wed Jun 24 05:04:23 CST 2020, time=2020-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1589830, encodeId=101115898301f, content=<a href='/topic/show?id=124d10065220' target=_blank style='color:#2F92EE;'>#颈部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100652, encryptionId=124d10065220, topicName=颈部)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c46a17776631, createdName=木头人519, createdTime=Wed Jun 24 05:04:23 CST 2020, time=2020-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038052, encodeId=d1d2103805222, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Mon Jun 22 17:04:23 CST 2020, time=2020-06-22, status=1, ipAttribution=)]
    2020-09-11 guoyibin
  6. [GetPortalCommentsPageByObjectIdResponse(id=970330, encodeId=c4259e03302f, content=对其他部位粘膜炎有效吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=1ef41537097, createdName=imp_xiaoww, createdTime=Wed Jun 02 13:22:52 CST 2021, time=2021-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1865852, encodeId=ad661865852c7, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Fri Jun 26 09:04:23 CST 2020, time=2020-06-26, status=1, 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topicList=[TopicDto(id=66750, encryptionId=265c66e50ea, topicName=激光)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4fd6156, createdName=oliver169, createdTime=Wed Jun 24 05:04:23 CST 2020, time=2020-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1434728, encodeId=2bbd1434e281f, content=<a href='/topic/show?id=817f66e686a' target=_blank style='color:#2F92EE;'>#激光治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66768, encryptionId=817f66e686a, topicName=激光治疗)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Wed Jun 24 05:04:23 CST 2020, time=2020-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491863, encodeId=685f14918633b, content=<a href='/topic/show?id=b4f14442346' target=_blank style='color:#2F92EE;'>#头颈部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44423, encryptionId=b4f14442346, topicName=头颈部)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0b2d8903151, createdName=wshxjq, createdTime=Wed Jun 24 05:04:23 CST 2020, time=2020-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1589830, encodeId=101115898301f, content=<a href='/topic/show?id=124d10065220' target=_blank style='color:#2F92EE;'>#颈部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100652, encryptionId=124d10065220, topicName=颈部)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c46a17776631, createdName=木头人519, createdTime=Wed Jun 24 05:04:23 CST 2020, time=2020-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038052, encodeId=d1d2103805222, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Mon Jun 22 17:04:23 CST 2020, time=2020-06-22, status=1, ipAttribution=)]
    2020-06-24 oliver169
  7. 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  8. 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05:04:23 CST 2020, time=2020-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038052, encodeId=d1d2103805222, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Mon Jun 22 17:04:23 CST 2020, time=2020-06-22, status=1, ipAttribution=)]
    2020-06-24 wshxjq
  9. 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  10. 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05:04:23 CST 2020, time=2020-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1038052, encodeId=d1d2103805222, content=谢谢梅斯分享这么多精彩信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=anti-cancer, createdTime=Mon Jun 22 17:04:23 CST 2020, time=2020-06-22, status=1, ipAttribution=)]
    2020-06-22 anti-cancer

    谢谢梅斯分享这么多精彩信息

    0

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J Allergy Clin Immunol:鼻息肉与未来头颈癌风险研究

鼻息肉是一种常见的疾病,并且显著的影响生活质量。鼻息肉与头颈癌风险的相关性仍旧未知。最近,有研究人员在一个基于群体的回顾性鼻息肉患者以及匹配的比较者中调查了鼻腔鼻窦(NCPS)和鼻咽肿瘤的相对风险情况。研究包括了453892名鼻息肉患者和4583938名匹配的比较者。平均跟踪调查时间为6.2年(范围2-13年)。鼻息肉患者与比较这NCPS的发生比值为7.00(95% CI: 5.28-9.25),

JAMA Otolaryngol Head Neck Surg:头颈癌患者放疗和顺铂化疗后听力损失预测研究

在头颈癌患者进行治疗之前,进行术后准确、易行的听力损失预测对患者进行治疗决定是必要的信息。最近,有研究人员对头颈癌患者开发了一种预测放疗后和/或者顺铂化疗后预测听力损失的模型。研究包括了242名头颈癌患者(482只耳朵,56名女性,平均年龄60(10)岁),并进行了回顾性的群体研究。所有包括在研究中的患者接受了放疗,105名患者(43.4%)接受了顺铂化疗。平均总的顺铂剂量为298(109)mg/