Dig Dis Sci:溃疡性结肠炎患者以及术后炎症性肠病患者出院后静脉血栓栓塞的风险均明显上升

2021-06-28 MedSci原创 MedSci原创

目前我们知道,炎症性肠病 (IBD) 患者手术后住院期间内的静脉血栓栓塞 (VTE) 的风险增加是明确的,但是目前尚不清楚这种关联是否在出院后持续存在。因此,

      目前我们知道,炎症性肠病 (IBD) 患者手术后住院期间内的静脉血栓栓塞 (VTE) 的风险增加是明确的,但是目前尚不清楚这种关联是否在出院后持续存在。因此,对于这部分患者研究人员准备进行更为长期的随访研究来评估术后静脉血栓的发生率。

 

      研究人员于 2002 年至 2016 年在加拿大安大略省进行了一项基于人群的队列研究。将接受腹腔内手术的住院 72 小时以上的 IBD 成人与住院的非手术 IBD 患者进行了静脉血栓发生率的比较。多变量 Cox 比例风险模型用于比较出院后 12 个月内的 VTE 风险。

 

      本项研究最后共分析了 80445 例出院病例,其中60%是克罗恩病 (CD) ,40%是溃疡性结肠炎 (UC)。非手术CD患者发生 VTE 的中位时间是手术患者的3倍,UC 非手术患者发生VTE的中位时间比手术患者长1.6倍。与非手术患者相比,CD 手术与出院后 2 周内 VTE 的累积风险较低,并持续到出院后 12 个月(HR 0.24;95% CI 0.15–0.40)。相比之下,UC 的紧急手术与 VTE 风险增加有关。出院后 2 周的风险增加最大(aHR,1.80;95% CI 1.26-2.57),但在术后12 个月内中逐渐下降。

图:手术对于VTE的影响

      本项研究证实UC患者手术后与更大的 VTE 风险相关,但CD患者没有这样的现象。对于接受紧急手术的 UC 患者,临床医生对于术后VTE的问题需要更加重视。

 

 

原始出处:

Jeffrey D. McCurdy. Et al. Surgery and the Subtype of Inflammatory Bowel Disease Impact the Risk of Venous Thromboembolism After Hospital Discharge. Digestive Diseases and Sciences.2021.

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    2021-08-17 nymo
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    2021-10-09 fusion
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    2021-08-07 xue8602
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    2021-06-29 2289576799

    手术对ⅤTE的影响两周内逐渐下降

    0

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    2021-06-28 Leona Fan

    学习了

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