Neurology:REM睡眠行为障碍的危险因素

2020-08-11 MedSci原创 MedSci原创

该研究进一步佐证了先前报道,即pRBD与高脂血症、吸烟、农药接触以及一些前驱性PD症状之间存在关联。研究人员还发现以前未报道的结果,即pRBD与帕金森氏症/痴呆症和CO中毒的家族史有关。

近日,神经病学领域权威杂志Neurology上发表了一篇研究文章,该研究旨在探讨北京某社区人群特发性快速眼动(REM)睡眠行为障碍(RBD)的危险因素。

研究人员从北京纵向老龄化研究II(BLSA II)队列中招募了年龄处于55岁及以上的参与者,在2010年使用经过验证的RBD问卷(香港)确定了可能的RBD(pRBD)个体。在2009年,通过标准问卷对一系列环境、生活方式和其他潜在危险因素进行了评估。研究人员进行了多因素Logistic回归分析以调查研究因素和pRBD两者之间的相关性。

在7225名无帕金森病和痴呆症的参与者中,有219名(3.0%)被认为患有pRBD。患有pRBD的参与者报告了更多的帕金森氏病(PD)非运动和运动症状,其调整后的比值比(OR)从1.10至4.40。患有pRBD的参与者更有可能报告帕金森氏症或痴呆症的家族史(OR为3.03,95%置信区间[CI]为1.23-7.46)。pRBD与自我报告的高脂血症(OR为1.51,95%CI为1.09-2.10)、既往吸烟(OR为1.79,95%CI为1.20-2.65)、既往一氧化碳(CO)中毒(OR为2.30、95%CI为1.39-3.83)和非职业性接触农药(OR为2.21,95%CI为1.40-3.50)之间存在显著相关性。

该研究进一步佐证了先前报道,即pRBD与高脂血症、吸烟、农药接触以及一些前驱性PD症状之间存在关联。研究人员还发现以前未报道的结果,即pRBD与帕金森氏症/痴呆症和CO中毒的家族史有关。

原始出处:

Hui Zhang.et al.Risk factors for possible REM sleep behavior disorders: A community-based study in Beijing.Neurology.2020.https://doi.org/10.1212/WNL.0000000000010610

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    2021-05-08 yinhl1978
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    2020-12-24 tongyongming
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    2020-08-12 Psycho.Dr Du

    学习了,第一次听说RBD🧐

    0

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