BMJ:结直肠息肉或结直肠癌患者的一级亲属要早期筛查结直肠癌

2021-05-06 MedSci原创 MedSci原创

结直肠息肉患者的兄弟姐妹和子女患结直肠息肉的风险增加,特别是当一个以上的一级亲属或60岁之前诊断出息肉时。早发性结直肠癌的风险增加更为突出,并与结直肠癌家族史相关

结直肠癌(CRC)是全球癌症相关死亡的第二大原因,内镜筛查通过切除结直肠前病变,即结肠息肉,降低了CRC的发病率和死亡率,识别高危个体进行针对性筛查对于改善CRC的预防具有重要的公共卫生和经济意义。与已确定的与CRC家族史相关的风险增加相比,目前尚不清楚那些有结直肠息肉家族史的人是否会增加罹患CRC的风险。因此,对于有息肉家族史的个体,现有的筛查建议存在差异。美国Multi-Society结直肠癌工作组建议多发息肉家族史应以CRC家族史同样的方式进行早期筛查。而英国胃肠病协会的筛查建议只考虑了CRC家族史,未考虑息肉。考虑到息肉的发病率高于CRC,且内镜筛查的使用率增加,更好地了解息肉家族史对CRC风险的影响,对于改进目前的筛查建议至关重要。Mingyang Song的全国性病例对照研究中,使用了瑞典几个国家登记的信息来评估结直肠息肉家族史和结直肠癌风险之间的关系,评估结直肠癌前病变(息肉)患者的第一级亲属(父母和同胞)发生结直肠癌(CRC)的风险。研究成果发表在BMJ杂志。 该研究参与者为68060例CRC患者和333753例匹配的对照组。根据一级亲属中有结直肠息肉的人数、息肉的组织

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    2022-04-16 gaoxiaoe
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    2021-05-14 ms7000000414344418

    学习

    0

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    2021-05-06 翩翩白衣少年

    好好学习天天向上

    0

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    2021-05-06 14869cafm07(暂无昵称)

    学习了

    0

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