J Aller Cl Imm-Pract:叶酸代谢产物与儿童食物过敏的关系

2019-07-10 xing.T MedSci原创

在BBC儿童中,出生时UMFA浓度较高与FA的发生发展有关,这可能是由于子宫内合成叶酸的暴露增加或合成叶酸代谢的潜在遗传差异所致。

关于叶酸/叶酸暴露与过敏性疾病发生发展之间关系的研究已经得到了不一致的结果,这可能部分是由于没有区分叶酸和叶酸暴露的数据。近日,过敏性疾病领域权威杂志Journal of Allergy and Clinical Immunology-In Practice上发表了一篇研究文章,该研究旨在评估出生前和儿童早期总叶酸、5-甲基四氢叶酸(5-MTHF)和的未代谢叶酸(UMFA)浓度与食物致敏(FS)和食物过敏(FA)发生发展之间的关系。

研究人员在波士顿出生队列(BBC)中进行了巢式病例对照研究。在出生时和儿童早期测量了总叶酸、5-MTHF和UMFA。基于食物特异性IgE(sIgE)水平、饮食和临床病史,儿童被分类为FS(sIgE≥0.35kU/L)、FA或非FS/FA(对照者)。将叶酸浓度分成四分位数,并使用多重Logistic回归来估计OR和95%CI。

在1394名儿童中,研究人员确定了507名FS和78名FA儿童。虽然FA患者出生时平均总叶酸浓度较低(30.2 vs. 35.3 nmol/L; p=0.02),但合成叶酸衍生物UMFA的平均浓度较高(1.7 vs. 1.3 nmol/L, p=0.001)。出生时更高四分位数的UMFA与FA相关性更强(OR为8.50; 95%CI为1.7-42.8;趋势检验p=0.001)。儿童早期5-MTHF浓度和UMFA均与FS或FA的发生发展无关。

在BBC儿童中,出生时UMFA浓度较高与FA的发生发展有关,这可能是由于子宫内合成叶酸的暴露增加或合成叶酸代谢的潜在遗传差异所致。 

原始出处:

Emily C. McGowan,et al.Association Between Folate Metabolites and the Development of Food Allergy in Children.J Aller Cl Imm-Pract. 2019. https://doi.org/10.1016/j.jaip.2019.06.017

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    2019-07-11 膀胱癌
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    2019-07-11 yhy100201
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    2019-07-11 1466d35fm78暂无昵称

    非常不错,受益匪浅

    0

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    2019-07-10 1466d35fm78暂无昵称

    非常好,受益匪浅……

    0

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    2019-07-10 1466d35fm78暂无昵称

    厉害了

    0

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    2019-07-10 yydlt

    学习了不错

    0

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