Circulation:恩格列净可有效降低心力衰竭患者的肺动脉压

2021-04-27 Nebula MedSci原创

对于按装了肺动脉压力传感器的心衰患者,采用恩格列净治疗可快速降低PA压力,而且降压效果随着时间增强

钠-葡萄糖共转运蛋白2抑制剂(SGLT2抑制剂)可以预防2型糖尿病患者因心力衰竭(HF)而住院,并改善已发生射血分数降低的HF患者的结局,且不受2型糖尿病的影响。心力衰竭从SGLT2抑制剂治疗中获益的机制尚不清楚,而且也不知道SGLT2抑制剂对血液动力学(充盈压)的作用。 Nassif等人开展了一项多中心、随机双盲、安慰剂为对照的临床试验(EMBRACE-HF试验),尝试阐明上述问题。研究结果于近日发表在《循环》“Circulation”上。 从2017年7月至2019年11月,来自10个医疗中心的既往植入了肺动脉(PA)压力传感器(CardioMEMS)的HF患者(无论有无射血分数降低和2型糖尿病)被随机分至两组,接受恩格列净(10 mg/日)或安慰剂持续治疗12周。主要终点是PA舒张压(PADP)的变化。次要终点有健康状态(堪萨斯城心肌病问卷调查表得分)、利钠肽和六分钟步行距离。 总体上,共筛查了93位患者,其中65位被随机分组:恩格列净组33位、安慰剂组 32位。平均年龄为66岁,63%的男性,52%的患者合并2型糖尿病,54%的患者为NYHA III/IV级,平均射血分数为44

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    2021-05-26 Crystal4509

    学习了,谢谢分享

    0

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    2021-04-28 carrotlyl

    好消息

    0

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    2021-04-27 言西早

    对于按装了肺动脉压力传感器的心衰患者,采用恩格列净治疗可快速降低PA压力,而且降压效果随着时间增强。

    0

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    2021-04-27 ms2000001051330459

    学习了,涨知识了!

    0

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    2021-04-27 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

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    2021-04-27 ms5000000790714074

    0

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