Gut:质子泵抑制剂与胃癌风险

2021-07-07 MedSci原创 MedSci原创

这项基于人群的大型队列研究的结果表明,与使用H2RA治疗相比,使用PPI治疗与胃癌风险增加相关,尽管绝对风险仍然很低。

近日,消化病领域权威杂志Gut上发表了一篇研究文章,该研究旨在明确与组胺2型受体拮抗剂 (H2RAs)治疗相比,质子泵抑制剂(PPI)治疗是否会增加患胃癌的风险。

研究人员使用英国临床实践研究数据链,进行了一项基于人群的队列研究。从1990年1月1日到2018年4月30日,研究人员确定了973281名PPI新用户和193306名H2RA新用户。

Cox 比例风险模型用于估计胃癌的HR和95%CI,并且使用Kaplan-Meier方法估计了得到伤害性效应需要的人数。研究人员使用时间特定倾向评分得到标准化死亡率权重对模型进行加权。该研究的次要分析评估了持续时间和剂量反应的相关性。

中位随访5.0年后,与使用H2RA相比,使用PPI与胃癌风险增加45%相关(HR为1.45,95%CI为1.06到1.98)。在治疗开始后的5年和10年,分别需要治疗人数达到2121和1191人才出现伤害性效应。HR随着累积持续时间、累积奥美拉唑当量和治疗开始的时间而增加。多项敏感性分析的结果一致。

由此可见,这项基于人群的大型队列研究的结果表明,与使用H2RA治疗相比,使用PPI治疗与胃癌风险增加相关,尽管绝对风险仍然很低。

原始出处:

Devin Abrahami.et al.Proton pump inhibitors and risk of gastric cancer: population-based cohort study.Gut.2021.https://gut.bmj.com/content/early/2021/07/04/gutjnl-2021-325097

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    2022-01-17 jklm09
  3. 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createdAvatar=https://img.medsci.cn/20210707/1dc6d4b1289545db82cfe5a7704a6aac/ec4686c551d845c4a5d6a3be90c2c773.jpg, createdBy=ab972230455, createdName=携手, createdTime=Wed Jul 07 22:58:25 CST 2021, time=2021-07-07, status=1, ipAttribution=)]
    2021-11-04 1482963am12暂无昵称

    非常感谢

    0

  4. 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authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Sat Nov 06 14:21:50 CST 2021, time=2021-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=999709, encodeId=e7ad999e092c, content=PPI的滥用, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200818/45706d88944f4864a0fffa38b6498b6b/96f7dab5dbcf4fcfa7abc0bc766973cb.jpg, createdBy=d98f5411800, createdName=黄昏晓Time, createdTime=Thu Jul 15 12:08:49 CST 2021, time=2021-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=999667, encodeId=be2a99966e34, content=学习了,很实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Thu Jul 15 09:27:51 CST 2021, time=2021-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=997743, encodeId=94fe99e74367, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210709/a0bff1ca76894cb5b41541c0231bc76e/604098d82ef643be8dda750ee3fd7e05.jpg, createdBy=e64e5292268, createdName=下辈子, createdTime=Fri Jul 09 00:35:13 CST 2021, time=2021-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=997391, encodeId=e08b99e3913f, content=已读,学习,真是受益匪浅呀,, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f03a5433387, createdName=ms5000000518166734, createdTime=Thu Jul 08 07:00:21 CST 2021, time=2021-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=997378, encodeId=263199e37850, content=PPI类长期使用也有很大封箱捏, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=16292346597, createdName=122a105am95暂无昵称, createdTime=Thu Jul 08 01:04:45 CST 2021, time=2021-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=997345, encodeId=4fab99e345c4, content=特别有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210707/1dc6d4b1289545db82cfe5a7704a6aac/ec4686c551d845c4a5d6a3be90c2c773.jpg, createdBy=ab972230455, createdName=携手, createdTime=Wed Jul 07 22:58:25 CST 2021, time=2021-07-07, status=1, ipAttribution=)]
    2021-11-06 sjq027
  5. [GetPortalCommentsPageByObjectIdResponse(id=1667400, encodeId=133f166e400d7, content=<a href='/topic/show?id=03ab923565b' target=_blank style='color:#2F92EE;'>#质子泵#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92356, encryptionId=03ab923565b, topicName=质子泵)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=761326143554, createdName=shenxlcyp, createdTime=Mon Sep 06 02:21:50 CST 2021, time=2021-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1852700, encodeId=bc171852e00db, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, 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createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Thu Jul 15 09:27:51 CST 2021, time=2021-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=997743, encodeId=94fe99e74367, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210709/a0bff1ca76894cb5b41541c0231bc76e/604098d82ef643be8dda750ee3fd7e05.jpg, createdBy=e64e5292268, createdName=下辈子, createdTime=Fri Jul 09 00:35:13 CST 2021, time=2021-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=997391, encodeId=e08b99e3913f, content=已读,学习,真是受益匪浅呀,, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f03a5433387, createdName=ms5000000518166734, createdTime=Thu Jul 08 07:00:21 CST 2021, time=2021-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=997378, encodeId=263199e37850, content=PPI类长期使用也有很大封箱捏, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=16292346597, createdName=122a105am95暂无昵称, createdTime=Thu Jul 08 01:04:45 CST 2021, time=2021-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=997345, encodeId=4fab99e345c4, content=特别有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210707/1dc6d4b1289545db82cfe5a7704a6aac/ec4686c551d845c4a5d6a3be90c2c773.jpg, createdBy=ab972230455, createdName=携手, createdTime=Wed Jul 07 22:58:25 CST 2021, time=2021-07-07, status=1, ipAttribution=)]
    2021-07-15 黄昏晓Time

    PPI的滥用

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1667400, encodeId=133f166e400d7, content=<a href='/topic/show?id=03ab923565b' target=_blank style='color:#2F92EE;'>#质子泵#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92356, encryptionId=03ab923565b, topicName=质子泵)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=761326143554, createdName=shenxlcyp, createdTime=Mon Sep 06 02:21:50 CST 2021, time=2021-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1852700, encodeId=bc171852e00db, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, 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createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Thu Jul 15 09:27:51 CST 2021, time=2021-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=997743, encodeId=94fe99e74367, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210709/a0bff1ca76894cb5b41541c0231bc76e/604098d82ef643be8dda750ee3fd7e05.jpg, createdBy=e64e5292268, createdName=下辈子, createdTime=Fri Jul 09 00:35:13 CST 2021, time=2021-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=997391, encodeId=e08b99e3913f, content=已读,学习,真是受益匪浅呀,, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f03a5433387, createdName=ms5000000518166734, createdTime=Thu Jul 08 07:00:21 CST 2021, time=2021-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=997378, encodeId=263199e37850, content=PPI类长期使用也有很大封箱捏, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=16292346597, createdName=122a105am95暂无昵称, createdTime=Thu Jul 08 01:04:45 CST 2021, time=2021-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=997345, encodeId=4fab99e345c4, content=特别有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210707/1dc6d4b1289545db82cfe5a7704a6aac/ec4686c551d845c4a5d6a3be90c2c773.jpg, createdBy=ab972230455, createdName=携手, createdTime=Wed Jul 07 22:58:25 CST 2021, time=2021-07-07, status=1, ipAttribution=)]
    2021-07-15 tanxingdoctor

    学习了,很实用

    0

  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Thu Jul 15 09:27:51 CST 2021, time=2021-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=997743, encodeId=94fe99e74367, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210709/a0bff1ca76894cb5b41541c0231bc76e/604098d82ef643be8dda750ee3fd7e05.jpg, createdBy=e64e5292268, createdName=下辈子, createdTime=Fri Jul 09 00:35:13 CST 2021, time=2021-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=997391, encodeId=e08b99e3913f, content=已读,学习,真是受益匪浅呀,, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f03a5433387, createdName=ms5000000518166734, createdTime=Thu Jul 08 07:00:21 CST 2021, time=2021-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=997378, encodeId=263199e37850, content=PPI类长期使用也有很大封箱捏, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=16292346597, createdName=122a105am95暂无昵称, createdTime=Thu Jul 08 01:04:45 CST 2021, time=2021-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=997345, encodeId=4fab99e345c4, content=特别有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210707/1dc6d4b1289545db82cfe5a7704a6aac/ec4686c551d845c4a5d6a3be90c2c773.jpg, createdBy=ab972230455, createdName=携手, createdTime=Wed Jul 07 22:58:25 CST 2021, time=2021-07-07, status=1, ipAttribution=)]
    2021-07-09 下辈子

    学习

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1667400, encodeId=133f166e400d7, content=<a href='/topic/show?id=03ab923565b' target=_blank style='color:#2F92EE;'>#质子泵#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92356, encryptionId=03ab923565b, topicName=质子泵)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=761326143554, createdName=shenxlcyp, createdTime=Mon Sep 06 02:21:50 CST 2021, time=2021-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1852700, encodeId=bc171852e00db, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Mon Jan 17 01:21:50 CST 2022, time=2022-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1066744, encodeId=e4261066e448c, content=非常感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2020/02/15/7274ed1be4747d648e4e2f7f62fae403.jpg, createdBy=d8d65273314, createdName=1482963am12暂无昵称, createdTime=Thu Nov 04 00:04:39 CST 2021, time=2021-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2062022, encodeId=cd062062022e0, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Sat Nov 06 14:21:50 CST 2021, time=2021-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=999709, encodeId=e7ad999e092c, content=PPI的滥用, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200818/45706d88944f4864a0fffa38b6498b6b/96f7dab5dbcf4fcfa7abc0bc766973cb.jpg, createdBy=d98f5411800, createdName=黄昏晓Time, createdTime=Thu Jul 15 12:08:49 CST 2021, time=2021-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=999667, encodeId=be2a99966e34, content=学习了,很实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Thu Jul 15 09:27:51 CST 2021, time=2021-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=997743, encodeId=94fe99e74367, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210709/a0bff1ca76894cb5b41541c0231bc76e/604098d82ef643be8dda750ee3fd7e05.jpg, createdBy=e64e5292268, createdName=下辈子, createdTime=Fri Jul 09 00:35:13 CST 2021, time=2021-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=997391, encodeId=e08b99e3913f, content=已读,学习,真是受益匪浅呀,, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f03a5433387, createdName=ms5000000518166734, createdTime=Thu Jul 08 07:00:21 CST 2021, time=2021-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=997378, encodeId=263199e37850, content=PPI类长期使用也有很大封箱捏, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=16292346597, createdName=122a105am95暂无昵称, createdTime=Thu Jul 08 01:04:45 CST 2021, time=2021-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=997345, encodeId=4fab99e345c4, content=特别有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210707/1dc6d4b1289545db82cfe5a7704a6aac/ec4686c551d845c4a5d6a3be90c2c773.jpg, createdBy=ab972230455, createdName=携手, createdTime=Wed Jul 07 22:58:25 CST 2021, time=2021-07-07, status=1, ipAttribution=)]
    2021-07-08 ms5000000518166734

    已读,学习,真是受益匪浅呀,

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1667400, encodeId=133f166e400d7, content=<a href='/topic/show?id=03ab923565b' target=_blank style='color:#2F92EE;'>#质子泵#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92356, encryptionId=03ab923565b, topicName=质子泵)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=761326143554, createdName=shenxlcyp, createdTime=Mon Sep 06 02:21:50 CST 2021, time=2021-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1852700, encodeId=bc171852e00db, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Mon Jan 17 01:21:50 CST 2022, time=2022-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1066744, encodeId=e4261066e448c, content=非常感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2020/02/15/7274ed1be4747d648e4e2f7f62fae403.jpg, createdBy=d8d65273314, createdName=1482963am12暂无昵称, createdTime=Thu Nov 04 00:04:39 CST 2021, time=2021-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2062022, encodeId=cd062062022e0, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Sat Nov 06 14:21:50 CST 2021, time=2021-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=999709, encodeId=e7ad999e092c, content=PPI的滥用, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200818/45706d88944f4864a0fffa38b6498b6b/96f7dab5dbcf4fcfa7abc0bc766973cb.jpg, createdBy=d98f5411800, createdName=黄昏晓Time, createdTime=Thu Jul 15 12:08:49 CST 2021, time=2021-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=999667, encodeId=be2a99966e34, content=学习了,很实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Thu Jul 15 09:27:51 CST 2021, time=2021-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=997743, encodeId=94fe99e74367, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210709/a0bff1ca76894cb5b41541c0231bc76e/604098d82ef643be8dda750ee3fd7e05.jpg, createdBy=e64e5292268, createdName=下辈子, createdTime=Fri Jul 09 00:35:13 CST 2021, time=2021-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=997391, encodeId=e08b99e3913f, content=已读,学习,真是受益匪浅呀,, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f03a5433387, createdName=ms5000000518166734, createdTime=Thu Jul 08 07:00:21 CST 2021, time=2021-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=997378, encodeId=263199e37850, content=PPI类长期使用也有很大封箱捏, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=16292346597, createdName=122a105am95暂无昵称, createdTime=Thu Jul 08 01:04:45 CST 2021, time=2021-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=997345, encodeId=4fab99e345c4, content=特别有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210707/1dc6d4b1289545db82cfe5a7704a6aac/ec4686c551d845c4a5d6a3be90c2c773.jpg, createdBy=ab972230455, createdName=携手, createdTime=Wed Jul 07 22:58:25 CST 2021, time=2021-07-07, status=1, ipAttribution=)]
    2021-07-08 122a105am95暂无昵称

    PPI类长期使用也有很大封箱捏

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1667400, encodeId=133f166e400d7, content=<a href='/topic/show?id=03ab923565b' target=_blank style='color:#2F92EE;'>#质子泵#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92356, encryptionId=03ab923565b, topicName=质子泵)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=761326143554, createdName=shenxlcyp, createdTime=Mon Sep 06 02:21:50 CST 2021, time=2021-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1852700, encodeId=bc171852e00db, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Mon Jan 17 01:21:50 CST 2022, time=2022-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1066744, encodeId=e4261066e448c, content=非常感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2020/02/15/7274ed1be4747d648e4e2f7f62fae403.jpg, createdBy=d8d65273314, createdName=1482963am12暂无昵称, createdTime=Thu Nov 04 00:04:39 CST 2021, time=2021-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2062022, encodeId=cd062062022e0, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Sat Nov 06 14:21:50 CST 2021, time=2021-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=999709, encodeId=e7ad999e092c, content=PPI的滥用, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200818/45706d88944f4864a0fffa38b6498b6b/96f7dab5dbcf4fcfa7abc0bc766973cb.jpg, createdBy=d98f5411800, createdName=黄昏晓Time, createdTime=Thu Jul 15 12:08:49 CST 2021, time=2021-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=999667, encodeId=be2a99966e34, content=学习了,很实用, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Thu Jul 15 09:27:51 CST 2021, time=2021-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=997743, encodeId=94fe99e74367, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210709/a0bff1ca76894cb5b41541c0231bc76e/604098d82ef643be8dda750ee3fd7e05.jpg, createdBy=e64e5292268, createdName=下辈子, createdTime=Fri Jul 09 00:35:13 CST 2021, time=2021-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=997391, encodeId=e08b99e3913f, content=已读,学习,真是受益匪浅呀,, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f03a5433387, createdName=ms5000000518166734, createdTime=Thu Jul 08 07:00:21 CST 2021, time=2021-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=997378, encodeId=263199e37850, content=PPI类长期使用也有很大封箱捏, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=16292346597, createdName=122a105am95暂无昵称, createdTime=Thu Jul 08 01:04:45 CST 2021, time=2021-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=997345, encodeId=4fab99e345c4, content=特别有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210707/1dc6d4b1289545db82cfe5a7704a6aac/ec4686c551d845c4a5d6a3be90c2c773.jpg, createdBy=ab972230455, createdName=携手, createdTime=Wed Jul 07 22:58:25 CST 2021, time=2021-07-07, status=1, ipAttribution=)]
    2021-07-07 携手

    特别有用

    0

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