局麻下经椎间孔镜治疗腰椎间盘突出症术中并发呼吸性碱中毒1例

2018-05-09 苍成友 彭星 段瑞 实用疼痛学杂志

腰椎间盘突出症的手术治疗虽然可以取得较好疗效,但组织创伤大,术后恢复时间长,多数患者不容易接受。椎间孔镜髓核摘除术属微创手术中的一种,具有组织创伤小、术后恢复快等优点,常用于治疗腰椎间盘突出症。Jhala等与Tzaan报道,其并发症主要有椎间隙感染、神经根损伤、硬膜囊破裂、腹腔脏器及大血管损伤。近日,我科在局麻下为一腰椎间盘突出症患者行椎间孔镜下L4~5椎间盘突出物摘除、神经根松解与椎管成型术,手

【病例摘要】

腰椎间盘突出症的手术治疗虽然可以取得较好疗效,但组织创伤大,术后恢复时间长,多数患者不容易接受。椎间孔镜髓核摘除术属微创手术中的一种,具有组织创伤小、术后恢复快等优点,常用于治疗腰椎间盘突出症。Jhala等与Tzaan报道,其并发症主要有椎间隙感染、神经根损伤、硬膜囊破裂、腹腔脏器及大血管损伤。近日,我科在局麻下为一腰椎间盘突出症患者行椎间孔镜下L4~5椎间盘突出物摘除、神经根松解与椎管成型术,手术即将结束时,患者突发胸闷、呼吸困难、头晕、眼花,急查血气分析提示严重呼吸性碱中毒,现报道如下。

【一般资料】

患者,男,62岁,

【主诉】

因“腰及右下肢疼痛麻木1年余”入院。

【现病史】

患者1年多前无明显诱因出现腰及右下肢疼痛麻木,主要为腰骶、臀、右侧大小腿外侧,呈牵扯样疼痛;久站、久行、久坐时疼痛麻木加重,休息后缓解。2个多月前患者上述症状加重,主要为腰骶臀部、右下肢大腿外侧、小腿前侧、小腿外侧与足背,呈阵发性、牵扯样痛,伴腰及右下肢无力,右下肢持续麻木感,并有小腿前侧、小腿外侧与足背针刺样疼痛;无大小便障碍。

【体格检查】

扶入病房,慢性病容,腰椎活动度:屈70°角,伸5°角,左右侧屈20°角,旋转受限;L2~S1椎旁压痛,右侧L4-5,L5~S1旁开2.5cm压痛明显,并向右下肢放射,双侧臀大、中肌压痛,右侧明显;直腿抬高试验:右侧65°角阳性,加强试验阳性;左侧阴性;4字征:左、右侧阴性;梨状肌牵拉试验:左、右阳性;仰卧挺腹试验不能完成;右膝下皮肤色素沉着,双侧胫骨前、踝部、足背凹陷性水肿;右下肢肌力2级,左下肢4级;踝背屈肌力:右侧4级,左侧5级;跨背伸肌力:左侧4级,右侧2级;膝腱反射:左、右侧消失;跟腱放射:左、右侧消失;左下肢皮肤大腿外侧、小腿外侧、足背浅感觉减退,以大腿外侧最为明显;巴氏征、克氏征等病理反射未引出。

【辅助检查】

腰椎CT、MRI均显示L4-5椎间盘右外侧巨大突出伴椎管狭窄,L5神经根明显受压(见图1、图2)。


图1  CT示L4-5椎间盘突出并椎管狭窄,箭头指术前L4-5椎间盘右后外侧巨大突出,L5神经受压,椎管狭窄
 
图2  MRI示L4-5椎间盘突出并椎管狭窄,箭头指术前L4-5椎间盘右后外侧巨大突出,L5神经根受压

【初步诊断

结合患者病史、体征及辅助检查,诊断为腰椎间盘突出症并椎管狭窄症(L4~5)。

【治疗】

治疗方法与意外经过在局麻下行椎间孔镜下L4~5椎间盘突出物摘除、神经根松解、椎管成型术,术前5min予芬太尼注射液(fentanyl)1mg静脉注射。采取右外侧入路,手术开始时1%利多卡因(lidocaine)20ml逐层麻醉直至小关节突,而后在局麻穿刺点插入一个18G穿刺针到达突出髓核的后外侧,逐步建立1二作通道,置入椎间孔镜(图3、图4)。手术开始50min后在进行神经根松解时患者诉疼痛难忍,大汗淋漓,VAS评分估计7~8,立即暂停手术,静脉注射芬太尼0.5mg,咪达唑仑(midazolam)2mg,患者疼痛消失后继续手术。手术即将结束时,患者突发胸闷、呼吸困难、头晕、四肢抽搐、嗜睡,心电监测显示:BP180/115mmHg,P156次Imin,HR42次/min,立即结束手术。翻身平卧,予以面罩吸氧5L/min,咪达唑仑2mg静脉注射,并以硝酸甘油(nitroglycerine)10mg加0.9%生理盐水共50ml,以6ml/h静脉泵入。处理后BP146/102mmHg,P126次/min,HR32次/min,患者仍诉有胸闷、呼吸困难、头晕。急查血气分析:PCO215.1mmHg,pH7.48,PO2113mmHg,Na+141mmol/L,Ca++1.14mmol/L,HCO3—16.9mmol/L,BE一9.7mmol/L,呈代偿性急性呼吸性碱中毒。予低流量二氧化碳3L/min与氧气5L/min混合吸入,并每30min查1次血气分析,监测PCO2。患者胸闷、呼吸困难、头晕、四肢抽搐等症状随着PCO2上升逐渐改善。最后1次血气分析PCO229.7mmHg,pH7.48,PO295mmHg,Na+141mmol/L,Ca2+1.22mmol/L,HCO3-21.6mmol/L,BE一0.6mmol/L。随后患者意识清楚,胸闷、呼吸困难、头晕、四肢抽搐等症状消失。治疗过程历时2.5h,返回病房后继续予以心电监测,密切观察患者情况,于术后第3日腰腿痛明显缓解出院。


图3  L4-5间隙右外侧入路,图中黑色针状物为工作套管

图4  箭头示椎间孔镜下松解后的神经根

原始出处:

苍成友, 彭星, 段瑞,等. 局麻下经椎间孔镜治疗腰椎间盘突出症术中并发呼吸性碱中毒1例[J]. 实用疼痛学杂志, 2017, 13(1):30-32.

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createdBy=ebc924907730, createdName=zhty5345, createdTime=Wed Oct 31 23:16:00 CST 2018, time=2018-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1663861, encodeId=cc1e16638610b, content=<a href='/topic/show?id=f6304e66252' target=_blank style='color:#2F92EE;'>#局麻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47662, encryptionId=f6304e66252, topicName=局麻)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48cb25693766, createdName=12498b08m98暂无昵称, createdTime=Mon Dec 03 05:16:00 CST 2018, time=2018-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1805482, encodeId=a9501805482bf, content=<a href='/topic/show?id=5806e8329a3' target=_blank style='color:#2F92EE;'>#经椎间孔镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73707, encryptionId=e887e37075c, topicName=碱中毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4f32220, createdName=lancelotzzl, createdTime=Fri Nov 16 11:16:00 CST 2018, time=2018-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1736638, encodeId=1c4b1e36638c1, content=<a href='/topic/show?id=0192628906a' target=_blank style='color:#2F92EE;'>#椎间孔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62890, encryptionId=0192628906a, topicName=椎间孔)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=273734174228, createdName=ms622625817193301, createdTime=Mon Feb 18 16:16:00 CST 2019, time=2019-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272081, encodeId=1e8312e208170, content=<a href='/topic/show?id=cd1a854340b' target=_blank style='color:#2F92EE;'>#腰椎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85434, encryptionId=cd1a854340b, topicName=腰椎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Fri May 11 07:16:00 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1319078, encodeId=d10113190e8ab, content=<a href='/topic/show?id=14d92231508' target=_blank style='color:#2F92EE;'>#中毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22315, encryptionId=14d92231508, topicName=中毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Fri May 11 07:16:00 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1615404, encodeId=1db41615404bb, content=<a href='/topic/show?id=6c6b85465c0' target=_blank style='color:#2F92EE;'>#腰椎间盘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85465, encryptionId=6c6b85465c0, topicName=腰椎间盘)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7c4619628184, createdName=12498974m57暂无昵称, createdTime=Fri May 11 07:16:00 CST 2018, time=2018-05-11, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1757986, encodeId=3e541e57986f9, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Tue Mar 05 21:16:00 CST 2019, time=2019-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1658702, encodeId=14221658e028c, content=<a href='/topic/show?id=428462892bd' target=_blank style='color:#2F92EE;'>#椎间孔镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62892, encryptionId=428462892bd, topicName=椎间孔镜)], attachment=null, authenticateStatus=null, createdAvatar=null, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73707, encryptionId=e887e37075c, topicName=碱中毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4f32220, createdName=lancelotzzl, createdTime=Fri Nov 16 11:16:00 CST 2018, time=2018-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1736638, encodeId=1c4b1e36638c1, content=<a href='/topic/show?id=0192628906a' target=_blank style='color:#2F92EE;'>#椎间孔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62890, encryptionId=0192628906a, topicName=椎间孔)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=273734174228, createdName=ms622625817193301, createdTime=Mon Feb 18 16:16:00 CST 2019, time=2019-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272081, encodeId=1e8312e208170, content=<a href='/topic/show?id=cd1a854340b' target=_blank style='color:#2F92EE;'>#腰椎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85434, encryptionId=cd1a854340b, topicName=腰椎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Fri May 11 07:16:00 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1319078, encodeId=d10113190e8ab, content=<a href='/topic/show?id=14d92231508' target=_blank style='color:#2F92EE;'>#中毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22315, encryptionId=14d92231508, topicName=中毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Fri May 11 07:16:00 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1615404, encodeId=1db41615404bb, content=<a href='/topic/show?id=6c6b85465c0' target=_blank style='color:#2F92EE;'>#腰椎间盘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85465, encryptionId=6c6b85465c0, topicName=腰椎间盘)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7c4619628184, createdName=12498974m57暂无昵称, createdTime=Fri May 11 07:16:00 CST 2018, time=2018-05-11, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1757986, encodeId=3e541e57986f9, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Tue Mar 05 21:16:00 CST 2019, time=2019-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1658702, encodeId=14221658e028c, content=<a href='/topic/show?id=428462892bd' target=_blank style='color:#2F92EE;'>#椎间孔镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62892, encryptionId=428462892bd, topicName=椎间孔镜)], attachment=null, authenticateStatus=null, createdAvatar=null, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73707, encryptionId=e887e37075c, topicName=碱中毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4f32220, createdName=lancelotzzl, createdTime=Fri Nov 16 11:16:00 CST 2018, time=2018-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1736638, encodeId=1c4b1e36638c1, content=<a href='/topic/show?id=0192628906a' target=_blank style='color:#2F92EE;'>#椎间孔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62890, encryptionId=0192628906a, topicName=椎间孔)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=273734174228, createdName=ms622625817193301, createdTime=Mon Feb 18 16:16:00 CST 2019, time=2019-02-18, status=1, ipAttribution=), 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createdName=mashirong, createdTime=Fri May 11 07:16:00 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1615404, encodeId=1db41615404bb, content=<a href='/topic/show?id=6c6b85465c0' target=_blank style='color:#2F92EE;'>#腰椎间盘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85465, encryptionId=6c6b85465c0, topicName=腰椎间盘)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7c4619628184, createdName=12498974m57暂无昵称, createdTime=Fri May 11 07:16:00 CST 2018, time=2018-05-11, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1757986, encodeId=3e541e57986f9, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Tue Mar 05 21:16:00 CST 2019, time=2019-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1658702, encodeId=14221658e028c, content=<a href='/topic/show?id=428462892bd' target=_blank style='color:#2F92EE;'>#椎间孔镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62892, encryptionId=428462892bd, topicName=椎间孔镜)], attachment=null, authenticateStatus=null, createdAvatar=null, 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topicList=[TopicDto(id=78329, encryptionId=5806e8329a3, topicName=经椎间孔镜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5494471, createdName=HNYYM, createdTime=Wed Dec 26 09:16:00 CST 2018, time=2018-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1683764, encodeId=e9d81683e64cb, content=<a href='/topic/show?id=599862899ba' target=_blank style='color:#2F92EE;'>#椎间盘突出#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62899, encryptionId=599862899ba, topicName=椎间盘突出)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=104527995107, createdName=lfyang, createdTime=Thu May 24 07:16:00 CST 2018, time=2018-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1801393, encodeId=8d7d180139327, content=<a href='/topic/show?id=e887e37075c' target=_blank style='color:#2F92EE;'>#碱中毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73707, encryptionId=e887e37075c, topicName=碱中毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4f32220, createdName=lancelotzzl, createdTime=Fri Nov 16 11:16:00 CST 2018, time=2018-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1736638, encodeId=1c4b1e36638c1, content=<a href='/topic/show?id=0192628906a' target=_blank style='color:#2F92EE;'>#椎间孔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62890, encryptionId=0192628906a, topicName=椎间孔)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=273734174228, createdName=ms622625817193301, createdTime=Mon Feb 18 16:16:00 CST 2019, time=2019-02-18, status=1, ipAttribution=), 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createdName=mashirong, createdTime=Fri May 11 07:16:00 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1615404, encodeId=1db41615404bb, content=<a href='/topic/show?id=6c6b85465c0' target=_blank style='color:#2F92EE;'>#腰椎间盘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85465, encryptionId=6c6b85465c0, topicName=腰椎间盘)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7c4619628184, createdName=12498974m57暂无昵称, createdTime=Fri May 11 07:16:00 CST 2018, time=2018-05-11, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1757986, encodeId=3e541e57986f9, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Tue Mar 05 21:16:00 CST 2019, time=2019-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1658702, encodeId=14221658e028c, content=<a href='/topic/show?id=428462892bd' target=_blank style='color:#2F92EE;'>#椎间孔镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62892, encryptionId=428462892bd, topicName=椎间孔镜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ebc924907730, createdName=zhty5345, createdTime=Wed Oct 31 23:16:00 CST 2018, time=2018-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1663861, encodeId=cc1e16638610b, content=<a href='/topic/show?id=f6304e66252' target=_blank style='color:#2F92EE;'>#局麻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47662, encryptionId=f6304e66252, topicName=局麻)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48cb25693766, createdName=12498b08m98暂无昵称, createdTime=Mon Dec 03 05:16:00 CST 2018, time=2018-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1805482, encodeId=a9501805482bf, content=<a href='/topic/show?id=5806e8329a3' target=_blank style='color:#2F92EE;'>#经椎间孔镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78329, encryptionId=5806e8329a3, topicName=经椎间孔镜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5494471, createdName=HNYYM, createdTime=Wed Dec 26 09:16:00 CST 2018, time=2018-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1683764, encodeId=e9d81683e64cb, content=<a href='/topic/show?id=599862899ba' target=_blank style='color:#2F92EE;'>#椎间盘突出#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62899, encryptionId=599862899ba, topicName=椎间盘突出)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=104527995107, createdName=lfyang, createdTime=Thu May 24 07:16:00 CST 2018, time=2018-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1801393, encodeId=8d7d180139327, content=<a href='/topic/show?id=e887e37075c' target=_blank style='color:#2F92EE;'>#碱中毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73707, encryptionId=e887e37075c, topicName=碱中毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4f32220, createdName=lancelotzzl, createdTime=Fri Nov 16 11:16:00 CST 2018, time=2018-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1736638, encodeId=1c4b1e36638c1, content=<a href='/topic/show?id=0192628906a' target=_blank style='color:#2F92EE;'>#椎间孔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62890, encryptionId=0192628906a, topicName=椎间孔)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=273734174228, createdName=ms622625817193301, createdTime=Mon Feb 18 16:16:00 CST 2019, time=2019-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272081, encodeId=1e8312e208170, content=<a href='/topic/show?id=cd1a854340b' target=_blank style='color:#2F92EE;'>#腰椎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85434, encryptionId=cd1a854340b, topicName=腰椎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Fri May 11 07:16:00 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1319078, encodeId=d10113190e8ab, content=<a href='/topic/show?id=14d92231508' target=_blank style='color:#2F92EE;'>#中毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22315, encryptionId=14d92231508, topicName=中毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Fri May 11 07:16:00 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1615404, encodeId=1db41615404bb, content=<a href='/topic/show?id=6c6b85465c0' target=_blank style='color:#2F92EE;'>#腰椎间盘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85465, encryptionId=6c6b85465c0, topicName=腰椎间盘)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7c4619628184, createdName=12498974m57暂无昵称, createdTime=Fri May 11 07:16:00 CST 2018, time=2018-05-11, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1757986, encodeId=3e541e57986f9, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Tue Mar 05 21:16:00 CST 2019, time=2019-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1658702, encodeId=14221658e028c, content=<a href='/topic/show?id=428462892bd' target=_blank style='color:#2F92EE;'>#椎间孔镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62892, encryptionId=428462892bd, topicName=椎间孔镜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ebc924907730, createdName=zhty5345, createdTime=Wed Oct 31 23:16:00 CST 2018, time=2018-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1663861, encodeId=cc1e16638610b, content=<a href='/topic/show?id=f6304e66252' target=_blank style='color:#2F92EE;'>#局麻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47662, encryptionId=f6304e66252, topicName=局麻)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48cb25693766, createdName=12498b08m98暂无昵称, createdTime=Mon Dec 03 05:16:00 CST 2018, time=2018-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1805482, encodeId=a9501805482bf, content=<a href='/topic/show?id=5806e8329a3' target=_blank style='color:#2F92EE;'>#经椎间孔镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, 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beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73707, encryptionId=e887e37075c, topicName=碱中毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4f32220, createdName=lancelotzzl, createdTime=Fri Nov 16 11:16:00 CST 2018, time=2018-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1736638, encodeId=1c4b1e36638c1, content=<a href='/topic/show?id=0192628906a' target=_blank style='color:#2F92EE;'>#椎间孔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62890, encryptionId=0192628906a, topicName=椎间孔)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=273734174228, createdName=ms622625817193301, createdTime=Mon Feb 18 16:16:00 CST 2019, time=2019-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272081, encodeId=1e8312e208170, content=<a href='/topic/show?id=cd1a854340b' target=_blank style='color:#2F92EE;'>#腰椎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85434, encryptionId=cd1a854340b, topicName=腰椎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Fri May 11 07:16:00 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1319078, encodeId=d10113190e8ab, content=<a href='/topic/show?id=14d92231508' target=_blank style='color:#2F92EE;'>#中毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22315, encryptionId=14d92231508, topicName=中毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Fri May 11 07:16:00 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1615404, encodeId=1db41615404bb, content=<a href='/topic/show?id=6c6b85465c0' target=_blank style='color:#2F92EE;'>#腰椎间盘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85465, encryptionId=6c6b85465c0, topicName=腰椎间盘)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7c4619628184, createdName=12498974m57暂无昵称, createdTime=Fri May 11 07:16:00 CST 2018, time=2018-05-11, status=1, ipAttribution=)]
  9. [GetPortalCommentsPageByObjectIdResponse(id=1757986, encodeId=3e541e57986f9, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Tue Mar 05 21:16:00 CST 2019, time=2019-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1658702, encodeId=14221658e028c, content=<a href='/topic/show?id=428462892bd' target=_blank style='color:#2F92EE;'>#椎间孔镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62892, encryptionId=428462892bd, topicName=椎间孔镜)], attachment=null, authenticateStatus=null, createdAvatar=null, 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topicList=[TopicDto(id=78329, encryptionId=5806e8329a3, topicName=经椎间孔镜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5494471, createdName=HNYYM, createdTime=Wed Dec 26 09:16:00 CST 2018, time=2018-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1683764, encodeId=e9d81683e64cb, content=<a href='/topic/show?id=599862899ba' target=_blank style='color:#2F92EE;'>#椎间盘突出#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62899, encryptionId=599862899ba, topicName=椎间盘突出)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=104527995107, createdName=lfyang, createdTime=Thu May 24 07:16:00 CST 2018, time=2018-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1801393, encodeId=8d7d180139327, content=<a href='/topic/show?id=e887e37075c' target=_blank style='color:#2F92EE;'>#碱中毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73707, encryptionId=e887e37075c, topicName=碱中毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4f32220, createdName=lancelotzzl, createdTime=Fri Nov 16 11:16:00 CST 2018, time=2018-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1736638, encodeId=1c4b1e36638c1, content=<a href='/topic/show?id=0192628906a' target=_blank style='color:#2F92EE;'>#椎间孔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62890, encryptionId=0192628906a, topicName=椎间孔)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=273734174228, createdName=ms622625817193301, createdTime=Mon Feb 18 16:16:00 CST 2019, time=2019-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272081, encodeId=1e8312e208170, content=<a href='/topic/show?id=cd1a854340b' target=_blank style='color:#2F92EE;'>#腰椎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85434, encryptionId=cd1a854340b, topicName=腰椎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e93e105, createdName=anminleiryan, createdTime=Fri May 11 07:16:00 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1319078, encodeId=d10113190e8ab, content=<a href='/topic/show?id=14d92231508' target=_blank style='color:#2F92EE;'>#中毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22315, encryptionId=14d92231508, topicName=中毒)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Fri May 11 07:16:00 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1615404, encodeId=1db41615404bb, content=<a href='/topic/show?id=6c6b85465c0' target=_blank style='color:#2F92EE;'>#腰椎间盘#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85465, encryptionId=6c6b85465c0, topicName=腰椎间盘)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7c4619628184, createdName=12498974m57暂无昵称, createdTime=Fri May 11 07:16:00 CST 2018, time=2018-05-11, status=1, ipAttribution=)]
    2018-05-11 mashirong
  10. 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