J Neuroinflammation:急性缺血性脑卒中患者的HLA和杀伤细胞免疫球蛋白样受体(KIRs)基因分型

2020-04-06 MedSci原创 MedSci原创

在人类中,自然杀伤(NK)和T细胞靶标识别的主要成分取决于杀伤性免疫球蛋白样受体(KIR)对人白细胞抗原(HLA)I类分子的监视。本研究旨在了解急性缺血性脑卒中易感性的免疫学遗传背景与KIR基因和HL

在人类中,自然杀伤(NK)和T细胞靶标识别的主要成分取决于杀伤性免疫球蛋白样受体(KIR)对人白细胞抗原(HLA)I类分子的监视。本研究旨在了解急性缺血性脑卒中易感性的免疫学遗传背景与KIR基因和HLA等位基因的频率有关的知识。

 

对具有急性缺血性卒中的受试者和没有卒中的受试者进行基因分型,以确定是否存在KIR基因以及三个主要的KIR配体组,即HLA-B和HLA-A位点HLA-C1,HLA-C2和HLA-Bw4。

 

结果,在2013年11月至2016年2月之间,连续招募了急性缺血性卒中患者。作为健康对照,我们招募了没有急性缺血性卒中的受试者。与对照组相比,患有急性缺血性卒中的受试者表现出较高的2DL3、2DL5B,2DS2和2DS4 KIR基因频率,以及较低的HLA-B-Bw4I等位基因频率。没有急性缺血性卒中的受试者表现出较高的KIR 2DS2和HLAC2之间的相互作用频率。我们还观察到动脉粥样硬化(LAAS)亚型受试者中2DL3和2 DL4 KIR基因的频率更高。多元逻辑回归分析显示对HLA-B-Bw4I中风具有保护作用,并且KIR 2DL2与HLAC1和2DS2-HLAC2之间存在相互作用,并且对2DL2-HLA-C1_A之间的相互作用具有有害作用。

 

综上所述,我们发现激活KIR基因频率更高的发现似乎与先前报道的冠状动脉综合征患者的发现一致。缺血性卒中患者中“促炎”基因的这种较高频率也可以解释卒中急性期的免疫炎症激活。

 

原始出处:

 

Antonino TuttolomondoDomenico Di Raimondo, et al., HLA and killer cell immunoglobulin-like receptor (KIRs) genotyping in patients with acute ischemic stroke. J Neuroinflammation. 2019; 16: 88.

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  5. 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time=2020-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454861, encodeId=9f0114548612b, content=<a href='/topic/show?id=ca5f12e51d4' target=_blank style='color:#2F92EE;'>#NFL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12751, encryptionId=ca5f12e51d4, topicName=NFL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=90805606164, createdName=xiaoyeshuang, createdTime=Wed Apr 08 09:11:55 CST 2020, time=2020-04-08, status=1, ipAttribution=)]
    2021-02-23 lxg951
  6. 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time=2020-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454861, encodeId=9f0114548612b, content=<a href='/topic/show?id=ca5f12e51d4' target=_blank style='color:#2F92EE;'>#NFL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12751, encryptionId=ca5f12e51d4, topicName=NFL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=90805606164, createdName=xiaoyeshuang, createdTime=Wed Apr 08 09:11:55 CST 2020, time=2020-04-08, status=1, ipAttribution=)]
    2020-08-30 xzw113
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    2020-04-08 xiaoyeshuang

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Anoctamins最初被鉴定为是钙激活氯离子通道家族之一,但近期的研究表明了它们在不同类型恶性肿瘤发展过程中的作用。最近,有研究人员在10个anoctamin基因中评估了211个常见的单核苷酸多态性与局部前列腺癌根治性切除术(RP)后生化复发(BCR)之间的相关性情况。研究发现,在多次测试校正(P<0.05和q=0.232)和调整了已知的预后因素后,4个SNPs(ANO4 rs585335

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NAD (P) H:醌氧化还原酶1(NQO1)能够响应应激来调控细胞命运决定。氧化应激能够支持癌症维持和进展。之前的研究表明了前列腺癌细胞中NQO1(NQO1low)的敲除能够上调促炎细胞因子和激素阻断条件下细胞的生存。最近,有研究人员测试了NQO1low细胞形成肿瘤的能力。研究发现,与NQO1high细胞相比,NQO1low细胞能够形成恶性肿瘤。生物学活检和循环肿瘤细胞表明了前列腺癌的生化复发与

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三维计算机模型使得科学家们能够快速地确定哪些基因在哪些细胞中有活性,以及它们在器官中的精确位置。在一项新的研究中,德国亥姆霍兹协会马克斯-德尔布吕克分子医学中心的Nikolaus Rajewsky教授、以色列希伯来大学的Nir Friedman教授及其团队前不久在Nature期刊上发表了这种新的方法以及从中获得的新见解,论文标题为“Gene expression cartography”。

Sci Rep:导管型前列腺癌中HoxB13的表达

前列腺导管型恶性肿瘤(DAC)的组织学标准和选择性生物标记相对与腺泡型恶性肿瘤(AAC)来讲几乎还是未知。之前的研究表明了Hox13遗传变异与前列腺癌的致瘤过程相关。最近,有研究人员调查了HoxB13在前列腺癌中的临床病理特征,并比较了前列腺DAC和AAC的临床病理情况。研究人员通过涂片观察,鉴定了相当于格林森等级3和5的DAC表型编译。研究人员分别在训练集中鉴定了46.5%的案例(46/99)具