JCEM：2型糖尿病成年患者严重低血糖与心衰的关系

2021-11-22 MedSci原创 MedSci原创

在大型2型糖尿病成人患者队列中，严重低血糖与更高的HF风险之间存在独立的相关性。

心力衰竭(HF)和2型糖尿病很常见，且低血糖是糖尿病患者常见的并发症，但严重低血糖与心力衰竭(HF)发生率之间的关联尚未明确。

近日，内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章，研究人员旨在评估2型糖尿病患者中严重低血糖与心衰之间的关联。

研究人员从控制糖尿病心血管风险行动(ACCORD)研究中纳入了2型糖尿病参与者。在随机化后的最初24个月内评估严重低血糖事件，并使用2种方法进行定义：(1)需要医疗帮助的有症状的严重低血糖事件（第一个定义）；或(2)需要任何帮助（第二个定义）。在基线和研究的前24个月期间没有HF的参与者被前瞻性地随访了HF住院情况。研究人员采用多变量Cox回归生成严重低血糖和HF事件之间关联的调整后风险比(HR)。

在9208名参与者（平均年龄为63岁，38%为女性，62%为白人）中，365名受试者有1次以上严重低血糖发作。在中位随访3年期间，共发生了249起HF事件。在对相关混杂因素进行多变量调整后，与从未经历过任何低血糖发作的个体相比，需要医疗帮助的严重低血糖的参与者发生HF的相对风险高出68%（HR为1.68；95%CI为1.06-2.66）。需要任何帮助的严重低血糖也与HF相对风险高出49%相关（HR为1.49；95%CI为1.01-2.21）。

由此可见，在大型2型糖尿病成人患者队列中，严重低血糖与更高的HF风险之间存在独立的相关性。

原始出处：

Justin B Echouffo-Tcheugui,et al.Severe Hypoglycemia and Incident Heart Failure Among Adults With Type 2 Diabetes.JCEM.2021.https://academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgab836/6429719

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2022-05-13 achengzhao

#JCE#

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2022-05-07 仁者大医

#JCEM#

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2022-04-09 fmq_28614562

#严重低血糖#

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2021-11-23 454646258

👍

68 0
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2021-11-23 查查佳佳

究人员还分析了健康生活方式的潜在

61 0
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2021-11-23 学医无涯

学习一下

48 0
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2021-11-23 ms2000001510085796

题目新颖，内容丰富

57 0

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