Dig Dis Sci:炎症性肠病不会影响死亡率,但会增加急性心肌梗死患者的住院时间

2021-12-21 MedSci原创 MedSci原创

克罗恩病是一种原因不明的肠道炎症性疾病,在胃肠道的任何部位均可发生,但多发于末端回肠和右半结肠。本病和慢性非特异性溃疡性结肠炎两者统称为炎症性肠病(IBD)。

炎症性肠病 (IBD) 是一种免疫介导的复发性胃肠道 (GI) 炎症性疾病,其特征是慢性组织损伤和急性加重期反复交替。IBD主要包括溃疡性结肠炎(UC)和克罗恩病(CD),众所周知,炎症性自身免疫性疾病(例如类风湿性关节炎 (RA)、银屑病和系统性红斑狼疮)发生心血管 (CV) 事件的风险会增加。几项研究已经证明 IBD 和 CV 疾病之间存在类似的联系。越来越多的证据表明,动脉粥样硬化与先天性和适应性免疫系统失调以及血小板和内皮功能障碍有关。IBD 是由于遗传易感宿主的免疫和内皮系统功能障碍导致的慢性炎症过程。因此,潜在的慢性炎症过程可能会增加 IBD 患者的心血管风险。因此,本项研究旨在探究 IBD 患者心肌梗死 (MI) 的结果。

 

研究人员使用1998 年至 2010 年全美国住院患者样本的数据进行了一项横断面研究。 ICD-9-CM代码用于识别克罗恩病 (CD) (555.X)、溃疡性结肠炎 (UC) ( 556.X) 和急性心肌梗死 (410.X)的确诊患者。然后通过统计学分析比较了伴和不伴 IBD 的 MI 患者的预后结果,并进行了单变量分析。在调整混杂因素后,使用多变量逻辑回归来确定 UC 和 CD 对院内 MI 死亡率的影响。

 

本项研究总共纳入了2629161 名 MI患者,其中有3,607 名 UC 和 3784 名 CD 患者。UC([OR],1.12;95% CI 0.98–1.29)和 CD(OR 0.99;95% CI 0.86–1.15)不影响 MI 患者的院内死亡率。伴有或不伴有 UC 的 MI 患者(7.75% VS 7.05%;p  = 0.25)或伴有或不伴有 CD 的 MI 患者(6.50% VS 6.59%;p  = 0.87)的院内死亡率没有差异. 与非 IBD 患者相比,IBD 患者的住院时间 (LOS) 更长,UC 患者的总费用在统计学上更高(65,182 美元 VS. 53,542 美元;p < 0.001)。

 

该研究表明 IBD 不会影响 MI 的住院死亡率。然而,患有 IBD 的 MI 患者的 LOS 更长。UC 患者的总住院费用高于没有 IBD 的 MI 患者。需要进一步的前瞻性研究来评估 IBD 患者 MI 的结果。

原始出处 :

Preetika Sinh. Et al. Inflammatory Bowel Disease Does Not Impact Mortality but Increases Length of Hospitalization in Patients with Acute Myocardial Infarction. Digestive Diseases and Sciences.2021.

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    2022-01-06 屋顶瞄爱赏月

    学习了

    0

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    2022-01-03 病毒猎手

    #炎症性肠病#不会影响死亡率,但会增加急性#心肌梗死#患者的住院时间,可能还会增加其它一些疾病的风险

    0

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Cardiovasc Diabetol:真实世界既往无心梗/卒中病史人群中冠状动脉疾病合并2型糖尿病的发生率

THEMIS样人群CAD-T2DM的患病率估计为1.50/1000人,约占没有心肌梗死/卒中病史的CAD-T2DM患者的四分之一,而THEMIS-PCI样人群CAD-T2DM的患病率为0.27/100

心梗病人注意了!绝对静养是害,这样才是爱

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Cardiovasc Diabetol:心肌梗死后的心肌瘢痕对糖尿病患者左心室变形的影响

2 型糖尿病 (T2DM) 是冠状动脉疾病和心肌梗死 (MI) 的主要危险因素