Am J Clin Nutr:亚麻油对伴有代谢综合征的原发性高血压患者血管功能的影响

2021-12-06 Nebula MedSci原创

用亚麻油补充α-亚麻酸并不能改善有代谢综合征的高血压患者的血管功能,反而会负面影响其糖代谢

a-亚麻酸作为ω-3系不饱和脂肪酸的母体,被誉为“植物脑黄金”和“血液营养素”。ω-3系不饱和脂肪酸的主要成分为EPA和DHA。EPA是人体不可缺少的重要营养素,对人体的血管有着重要的作用。DHA俗称“脑黄金“,是一种对人体非常重要的多不饱和脂肪酸,主要存在于人体的大脑中。亚麻油中的a-亚麻酸高达50%以上,长期食用对人体的健康大有裨益。

迄今为止,含有植物ω-3 α-亚麻酸 (ALA) 的膳食添加剂对心血管稳态的影响尚不清楚。本研究旨在评估亚麻油对患有代谢综合征高血压患者的心血管和代谢功能的影响。

这是一项双盲、安慰剂为对照的随机研究,患有代谢综合征的原发性高血压患者在6个月内每天接受含有约1.5 g ALA的环糊精复合亚麻油(n=40)或由等量的环糊精和小麦淀粉组成等热量安慰剂(n=41)。测定人体测量数据、血脂、血糖、胰岛素血症、肌酐血症、硫代巴比妥酸反应物质、高敏C反应蛋白、红细胞膜上的n-3、n-6、n-9脂肪酸。评估外周和中心血压、动脉僵硬度、颈动脉内膜中层厚度和肱动脉内皮依赖性血流介导的扩张和内皮非依赖性扩张。

两组血流介导的扩张的变化

与安慰剂相比,摄入亚麻油可升高ALA(平均±SD:0±0.04 vs 0.08±0.06%,p<0.001)、其衍生物二十碳五烯酸(EPA:0±0.5 vs 0.16±0.65%,p<0.05)和n-9贡多酸(0±0.04 vs 0.08±0.04%, p<0.001)。但是,血流介导的血管扩张的变化与EPA变化的幅度有关 (r=0.26, p=0.03)。

两组HOMA-IR的变化

与安慰剂相比,亚麻油还可升高空腹血糖(-0.2±0.6 vs 0.3±0.5 mmol/L,p<0.001)和稳态模型评估的胰岛素抵抗指数(HOMA-IR:-0.8±2.5 vs 0.5±0.9, p<0.01),但不影响血脂或炎性及氧化应激标志物。HOMA-IR指数的变化与贡多酸的变化幅度相关 (r=0.32, p<0.01)。各组间的营养摄入量保持相似。

综上,用亚麻油补充ALA并不能改善有代谢综合征的高血压患者的血管功能,反而会负面影响其糖代谢。

原始出处:

Jeremy Bellien,Bozec Erwan,Bounoure Frédéric et al. The effect of camelina oil on vascular function in essential hypertensive patients with metabolic syndrome: A randomized, placebo-controlled, double-blind study.[J] .Am J Clin Nutr, 2021, https://doi.org/10.1093/ajcn/nqab374

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    2021-12-07 ZYY7209

    营养与疾病的关系复杂

    0

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    2021-12-07 查查佳佳

    上海市女医师协会从2021年9月启动

    0

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    2021-12-06 14835e9cm26暂无昵称

    很实用

    0

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