Ann Intern Med:低摄入量与高摄入量的红肉对心脏代谢和癌症结局的影响

2019-10-04 xing.T MedSci原创

由此可见,确定性低至非常低的证据表明,限制红肉饮食可能对主要的心脏代谢结局以及癌症死亡率和发病率几乎没有影响。

很少有随机试验评估减少红肉摄入量对临床重要结局的影响。近日,内科学权威杂志Annals of Internal Medicine上发表了一篇研究文章,该研究旨在总结较少或较多红肉摄入量对成年人心脏代谢和癌症结局发生率的影响。

研究人员检索了EMBASE、CENTRAL、CINAHL、Web of Science和ProQuest,这些数据库的检索时间从成立开始至2018年7月,研究人员也检索了MEDLINE,检索时间自数据库成立至2019年4月,没有语言限制。研究人员选择了比较高红肉饮食与低红肉饮食的随机试验(以任何语言发表),组间的差异通过每周至少1顿进行分级,持续6个月或更长时间。由2名审稿人组成的团队独立提取数据并评估偏倚风险和证据的确定性。

12项符合条件的试验中,一项招募了48835名妇女的试验提供了最可信的证据,尽管其不确定性仍然很低,其表明少吃红肉的饮食对全因死亡率(风险比[HR]为0.99[95%CI为0.95-1.03])、心血管疾病死亡率(HR为0.98[95%CI为0.91-1.06])和心血管疾病(HR为0.99[95%CI为0.94-1.05])几乎没有影响或没有影响。该试验还提供了低至极低确定性的证据,即减少红肉饮食对癌症总体死亡率(HR为0.95[95%CI为0.89-1.01])和癌症的发生率影响很小或没有影响,包括直肠癌(HR为1.04 [95%CI为0.90-1.20])和乳腺癌(HR为0.97 [95%CI为0.90-1.04])。

由此可见,确定性低至非常低的证据表明,限制红肉饮食可能对主要的心脏代谢结局以及癌症死亡率和发病率几乎没有影响。 

原始出处:

Dena Zeraatkar,et al.Effect of Lower Versus Higher Red Meat Intake on Cardiometabolic and Cancer Outcomes: A Systematic Review of Randomized Trials FREE.AIM.2019.https://annals.org/aim/fullarticle/2752326/effect-lower-versus-higher-red-meat-intake-cardiometabolic-cancer-outcomes

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    2020-03-14 lmm397
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