A&R:影像学和症状性手部骨关节炎的患病率、发病率和进展

2022-06-15 MedSci原创 MedSci原创

手部骨关节炎是一种异质性疾病,在年龄、性别、种族、手部症状和受影响的特定关节模式方面存在复杂的差异。有必要进一步研究调查这些差异背后的机制,无论是机械、代谢、荷尔蒙还是体质。

目的:手部骨关节炎(OA)是一种高度流行的疾病,可能导致严重的疼痛和残疾,它是一种异质性疾病,涉及不同的关节和不同程度的症状。该研究目的在于描述影像学和症状性手部OA的患病率、发病率和进展,并根据年龄、性别、种族和其他危险因素评估差异。

方法在基线和第4年评估参与者的影像学和症状性手部OA以确定发病率。使用具有稳健方差估计量的修正泊松回归来解释人手指内关节的聚类,以估计与参与者特征相关的患病率和相对风险估计。

结果3588名参与者中,影像学手OA的患病率为41.4%,症状性手OA的患病率为 12.4%48个月内影像学手部OA的发生率为5.6%,症状性手部OA16.9%。在48个月内,27.3%的参与者表现出OA进展。研究人员发现了年龄、性别和种族的复杂差异,随着年龄的增长,男性和女性手部OA的患病率都在增加,但女性发病率在55-64岁时达到顶峰。与男性相比,女性有症状的手部OA发生率显著较高,发生影像学手部OA的发生率较高但没有达到统计学差异。女性更常患有远端指间关节疾病,而男性更常患有掌指关节 OA黑人男性和女性的手部OA发生率低于白人参与者,但黑人男性的手部OA患病率高于年轻时的黑人女性。

结论手部OA是一种异质性疾病,在年龄、性别、种族、手部症状和受影响的特定关节模式方面存在复杂的差异。有必要进一步研究调查这些差异背后的机制,无论是机械、代谢、荷尔蒙还是体质。

出处:Eaton, C.B., Schaefer, L.F., Duryea, J., et al. (2022), Prevalence, Incidence, and Progression of Radiographic and Symptomatic Hand Osteoarthritis: The Osteoarthritis Initiative. Arthritis Rheumatol, 74: 992-1000. https://doi.org/10.1002/art.42076

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    2022-07-06 lisa438
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    2022-06-16 lmm397

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