Chest:Covid-19与静脉血栓栓塞风险的关系

2021-07-25 MedSci原创 MedSci原创

在不同人种的住院成人中,Covid-19感染增加了VTE的风险,并且患者特征与Covid-19环境中较高的血栓栓塞风险相关。

目前有限的数据表明2019新冠肺炎(Covid-19)可能会增加静脉血栓栓塞(VTE)的风险,但缺乏来自大型种族多样化人群的信息。

近日,呼吸领域权威杂志chest上发表了一篇研究文章,该研究旨在明确Covid-19住院成人的VTE发生率是否与没有Covid-19的匹配的住院对照者有何不同?

在2020年2月至2020年2月至8月期间,研究人员从36家医院的医疗保健服务系统对经实验室确诊的Covid-19住院成人和没有Covid-19的住院成人进行了一项回顾性研究。结局包括30天时的VTE(使用诊断代码结合应用于电子健康记录的经过验证的自然语言处理算法确定的深静脉血栓形成或肺栓塞)和任何原因死亡。在考虑了死亡的竞争风险和组间的残余差异后,研究人员进行精细和灰色风险回归以评估Covid-19与VTE之间的关联,并确定Covid-19患者发生VTE的预测因子。

Covid-19住院成人和没有Covid-19的对照者VTE结局分布情况

研究人员确定了6319名患有Covid-19的成年人和6319名没有Covid-19的匹配成年人,平均(SD)年龄为60.0(17.2)岁,其中女性占46%,西班牙裔占53.1%,亚洲/太平洋岛民占14.6%,黑人占10.3%。在30天的随访期间,发生了313例经过验证的VTE(160例Covid-19,153例对照者)和1172例死亡(817例Covid-19,355例对照者)。与匹配的对照者相比,患有Covid-19的成年人VTE调整后风险增加了三倍以上(调整后风险比为3.48,95%置信区间为2.03-5.98)。Covid-19患者发生VTE的预测因素包括年龄≥55岁、黑人、既往VTE、败血症、既往中度或重度肝病、体重指数≥40kg/m2和血小板计数>217k/mcL。

由此可见,在不同人种的住院成人中,Covid-19感染增加了VTE的风险,并且患者特征与Covid-19环境中较高的血栓栓塞风险相关。

原始出处:

Alan S. Go.et al.Covid-19 and Risk of Venous Thromboembolism in Ethnically Diverse Populations.chest.2021.https://journal.chestnet.org/inpress

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    2022-06-27 Smile2680
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Jul 25 14:37:49 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002500, encodeId=9d64100250081, content=理学物理核心思想观, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=62a85535130, createdName=ms3000001999514966, createdTime=Sun Jul 25 14:11:49 CST 2021, time=2021-07-25, status=1, ipAttribution=)]
    2021-10-03 xue8602
  5. [GetPortalCommentsPageByObjectIdResponse(id=1820470, encodeId=2e7f18204e01f, content=<a href='/topic/show?id=c87f10089032' target=_blank style='color:#2F92EE;'>#风险的关系#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100890, encryptionId=c87f10089032, topicName=风险的关系)], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/cc81592b507031e3cfd8d4c57911d98b/62c22832a9474aea1ca90ca058aebc03.jpg, createdBy=bed5446, createdName=limedical1974, createdTime=Wed Mar 30 00:56:12 CST 2022, time=2022-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1929665, encodeId=8a121929665cf, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, 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href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Wed Aug 11 20:56:12 CST 2021, time=2021-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004035, encodeId=01271004035ce, content=<a href='/topic/show?id=23c58911686' target=_blank style='color:#2F92EE;'>#血栓栓塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89116, encryptionId=23c58911686, topicName=血栓栓塞)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, 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  6. [GetPortalCommentsPageByObjectIdResponse(id=1820470, encodeId=2e7f18204e01f, content=<a href='/topic/show?id=c87f10089032' target=_blank style='color:#2F92EE;'>#风险的关系#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100890, encryptionId=c87f10089032, topicName=风险的关系)], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/cc81592b507031e3cfd8d4c57911d98b/62c22832a9474aea1ca90ca058aebc03.jpg, createdBy=bed5446, createdName=limedical1974, createdTime=Wed Mar 30 00:56:12 CST 2022, time=2022-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1929665, encodeId=8a121929665cf, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, 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href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Wed Aug 11 20:56:12 CST 2021, time=2021-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004035, encodeId=01271004035ce, content=<a href='/topic/show?id=23c58911686' target=_blank style='color:#2F92EE;'>#血栓栓塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89116, encryptionId=23c58911686, topicName=血栓栓塞)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=小小医者, createdTime=Fri Jul 30 22:03:02 CST 2021, time=2021-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002519, encodeId=b2021002519dc, content=嗯嗯,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=4feb2510775, createdName=桔子朵西西, createdTime=Sun Jul 25 16:32:19 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002506, encodeId=e722100250648, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210725/bad95e5b1ce84a0991ad2b478fd623c2/0f26dca0669b4e878b6fefcb41716927.jpg, createdBy=330f5445637, createdName=丁豆豆, createdTime=Sun Jul 25 14:37:49 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002500, encodeId=9d64100250081, content=理学物理核心思想观, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=62a85535130, createdName=ms3000001999514966, createdTime=Sun Jul 25 14:11:49 CST 2021, time=2021-07-25, status=1, ipAttribution=)]
    2021-08-11 fusion
  7. 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createdBy=7a3710, createdName=小小医者, createdTime=Fri Jul 30 22:03:02 CST 2021, time=2021-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002519, encodeId=b2021002519dc, content=嗯嗯,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=4feb2510775, createdName=桔子朵西西, createdTime=Sun Jul 25 16:32:19 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002506, encodeId=e722100250648, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210725/bad95e5b1ce84a0991ad2b478fd623c2/0f26dca0669b4e878b6fefcb41716927.jpg, createdBy=330f5445637, createdName=丁豆豆, createdTime=Sun Jul 25 14:37:49 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002500, encodeId=9d64100250081, content=理学物理核心思想观, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=62a85535130, createdName=ms3000001999514966, createdTime=Sun Jul 25 14:11:49 CST 2021, time=2021-07-25, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1820470, encodeId=2e7f18204e01f, content=<a href='/topic/show?id=c87f10089032' target=_blank style='color:#2F92EE;'>#风险的关系#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100890, encryptionId=c87f10089032, topicName=风险的关系)], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/cc81592b507031e3cfd8d4c57911d98b/62c22832a9474aea1ca90ca058aebc03.jpg, createdBy=bed5446, createdName=limedical1974, createdTime=Wed Mar 30 00:56:12 CST 2022, time=2022-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1929665, encodeId=8a121929665cf, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, 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href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Wed Aug 11 20:56:12 CST 2021, time=2021-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1004035, encodeId=01271004035ce, content=<a href='/topic/show?id=23c58911686' target=_blank style='color:#2F92EE;'>#血栓栓塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89116, encryptionId=23c58911686, topicName=血栓栓塞)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, 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Jul 25 14:37:49 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002500, encodeId=9d64100250081, content=理学物理核心思想观, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=62a85535130, createdName=ms3000001999514966, createdTime=Sun Jul 25 14:11:49 CST 2021, time=2021-07-25, status=1, ipAttribution=)]
    2021-07-25 桔子朵西西

    嗯嗯,学习了

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1820470, encodeId=2e7f18204e01f, content=<a href='/topic/show?id=c87f10089032' target=_blank style='color:#2F92EE;'>#风险的关系#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100890, encryptionId=c87f10089032, topicName=风险的关系)], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/cc81592b507031e3cfd8d4c57911d98b/62c22832a9474aea1ca90ca058aebc03.jpg, createdBy=bed5446, createdName=limedical1974, createdTime=Wed Mar 30 00:56:12 CST 2022, time=2022-03-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1929665, encodeId=8a121929665cf, content=<a href='/topic/show?id=9e604625ab' target=_blank style='color:#2F92EE;'>#Chest#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, 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Jul 25 14:37:49 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002500, encodeId=9d64100250081, content=理学物理核心思想观, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=62a85535130, createdName=ms3000001999514966, createdTime=Sun Jul 25 14:11:49 CST 2021, time=2021-07-25, status=1, ipAttribution=)]
    2021-07-25 丁豆豆

    学习了

    0

  10. 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Jul 25 14:37:49 CST 2021, time=2021-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1002500, encodeId=9d64100250081, content=理学物理核心思想观, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=62a85535130, createdName=ms3000001999514966, createdTime=Sun Jul 25 14:11:49 CST 2021, time=2021-07-25, status=1, ipAttribution=)]
    2021-07-25 ms3000001999514966

    理学物理核心思想观

    0

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较高的PAT和VAT,而非SAT,与HF和射血分数正常的HF相关,并且只有PAT与死亡率相关。

Gut:质子泵抑制剂与胃癌风险

这项基于人群的大型队列研究的结果表明,与使用H2RA治疗相比,使用PPI治疗与胃癌风险增加相关,尽管绝对风险仍然很低。

Thorax:肥胖个体慢性咳嗽的风险和影响因素

BMI和慢性咳嗽之间存在剂量-反应关系,并且肥胖个体的慢性咳嗽风险是普通人群的两倍到三倍。这种增加的风险部分是由GERD、低蔬菜摄入量和职业暴露所介导。

JCEM:体重指数和COVID-19患者诊断、住院和死亡风险的关系

BMI与COVID-19诊断和住院风险之间存在关联,但与死亡率呈J型关联。