Nature:吃完东西肚子疼?可能是肠胃局部过敏了……

2021-01-25 张佳兴 生物探索

肠易激综合征(IBS)主要表现为腹痛及肠道活动规律改变,其标志性症状是异常疼痛信号或内脏过敏 (VHS)。据报道,全世界有多达20%的人在饭后出现胃肠道症状。

肠易激综合征(IBS)主要表现为腹痛及肠道活动规律改变,其标志性症状是异常疼痛信号或内脏过敏 (VHS)。据报道,全世界有多达20%的人在饭后出现胃肠道症状,如果能够干预这种反应,就可以极大提高这一人群的生活质量。

肠道内存在着粘膜免疫系统,其对病原体和无害共生菌以及食物抗原提供平衡反应,从而限制不必要的炎症及其引起的组织损伤。然而病毒和细菌感染会干扰对膳食抗原的耐受性,因此传染性肠胃炎是IBS的一个重要危险因素。近来有研究人员提出:细菌感染导致的口服食物抗原耐受性破坏是食物诱导的VHS的基础。

近日,《Nature》杂志在线发表了比利时鲁汶大学Guy E. Boeckxstaens课题组名为“local immune response to food antigens drives meal-induced abdominal pain”的研究,提出肠道对食物抗原产生的局部免疫反应导致了进餐后腹痛。

在小鼠中,肠道细菌感染后对食物抗原的口服耐受性可能会下降,这会导致食物诱发的疼痛,类似于人的肠易激综合症。研究人员令小鼠感染枸橼酸杆菌C. rodentium后使用卵清蛋白(OVA)灌胃刺激小鼠肠道,发现小鼠仅出现局部免疫反应,而未见全身免疫反应的表现。进一步研究表明:胃肠道细菌感染可以打破口服对食物抗原的耐受性,导致肠道通透性增加,并在再次接触抗原时产生异常疼痛信号。

OVA刺激细菌感染后小鼠

感染后IBS的潜在机制可能与“低级别”炎症和肥大细胞激活增加有关。研究人员发现, B细胞和浆细胞局部产生的OVA特异性抗体使肥大细胞敏感,并随后介导再次暴露于OVA时肥大细胞的激活,促进了VHS的发生。肥大细胞介导的内脏疼痛信号的增加是由组胺1型受体(H1R)介导的,并且与香草酸瞬时受体亚型1(TRPV1)的敏化有关,H1R是组胺参与调节机体多种重要的生理病理功能的渠道,而TRPV1是在外周和中枢神经系统中广泛分布的通道蛋白。

肥大细胞在ova诱导的VHS发生发展中起关键作用

研究人员向12位IBS患者和8位健康志愿者的结肠粘膜中注入大豆、小麦、麸质和牛奶溶液。虽然参与者均不对这些膳食抗原过敏,但是IBS组的所有参与者均对至少一个食物抗原出现了粘膜反应,而只有两位健康志愿者出现单一阳性反应。进一步分析表明,食物抗原在IBS患者中引起肥大细胞激活,并可能是通过IgE介导的。不过,与食物过敏的根本区别是这些参与者仅在结肠组织中检测到OVA特异性IgE抗体,也就是说受试者仅出现了局部而非全身免疫应答。

粘膜内注射食物抗原可诱导肠易激综合征患者的粘膜反应

总而言之,此研究表明IBS是由肥大细胞激活介导的饮食诱发的疾病。这一概念对于IBS和相关疾病的治疗具有重要的意义。阻断肥大细胞介质可能有效,而IgE介导的肥大细胞激活也可能是IBS患者的预后生物标志物以及治疗靶标,从而为肠易激综合征和相关的腹痛疾病的治疗创造了新的可能性。

原始出处:

Javier Aguilera-Lizarraga, Morgane V Florens, Maria Francesca Viola,et al.Local immune response to food antigens drives meal-induced abdominal pain.Nature. 2021 Jan 13. doi: 10.1038/s41586-020-03118-2.

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    2021-09-22 liye789132251
  2. [GetPortalCommentsPageByObjectIdResponse(id=1884928, encodeId=048c1884928ff, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Wed Sep 22 00:46:51 CST 2021, time=2021-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=921031, encodeId=64a792103173, content=有可能 局部过敏, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2018/11/07/32f6eeca95f16df602e2fe81e7416090.jpg, createdBy=ddb32421444, createdName=精气神, createdTime=Fri Jan 29 13:49:02 CST 2021, time=2021-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920497, encodeId=6cfa92049e40, content=好方向, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210127/50a003c4097845e182c08afd64d8a509/bd766dfebe9c40e0bca2dae964601bdc.jpg, createdBy=22de5454917, createdName=carrotlyl, createdTime=Thu Jan 28 07:01:35 CST 2021, time=2021-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1406016, encodeId=0205140601694, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Wed Jan 27 12:46:51 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920165, encodeId=5353920165a2, content=肠道内存在着粘膜免疫系统,其对病原体和无害共生菌以及食物抗原提供平衡反应,从而限制不必要的炎症及其引起的组织损伤。, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4gCIdSaEkahCNuUWZv4iaKmqvUKHyKnBiarBM9RStQKBeV5Lh6GYYFiamdV5KlSfbLvmAgZTLtq81XA/0, createdBy=13511650672, createdName=言西早, createdTime=Tue Jan 26 23:14:26 CST 2021, time=2021-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920030, encodeId=d8d89200303f, content=学了, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210126/c01d15dc60f14ae8b30d0c00821d6ff5/fdcf111ae0f44884942a2902f856c367.jpg, createdBy=de5a5455674, createdName=来了, createdTime=Tue Jan 26 16:45:38 CST 2021, time=2021-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920015, encodeId=59b192001570, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=95901993306, createdName=1e1ad8bdm04(暂无匿称), createdTime=Tue Jan 26 16:01:26 CST 2021, time=2021-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919864, encodeId=8cc09198647b, content=IBS由肥大细胞激活诱导的疾病, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210125/b2bad80c90f1401091d00323c96bfb01/ef4aae86b90a4b3992bf86be9eb98d69.jpg, createdBy=f0062359976, createdName=koo!, createdTime=Mon Jan 25 22:09:38 CST 2021, time=2021-01-25, status=1, ipAttribution=)]
    2021-01-29 精气神

    有可能 局部过敏

    0

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    2021-01-28 carrotlyl

    好方向

    0

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    2021-01-27 chg122
  5. [GetPortalCommentsPageByObjectIdResponse(id=1884928, encodeId=048c1884928ff, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Wed Sep 22 00:46:51 CST 2021, time=2021-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=921031, encodeId=64a792103173, content=有可能 局部过敏, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2018/11/07/32f6eeca95f16df602e2fe81e7416090.jpg, createdBy=ddb32421444, createdName=精气神, createdTime=Fri Jan 29 13:49:02 CST 2021, time=2021-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920497, encodeId=6cfa92049e40, content=好方向, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210127/50a003c4097845e182c08afd64d8a509/bd766dfebe9c40e0bca2dae964601bdc.jpg, createdBy=22de5454917, createdName=carrotlyl, createdTime=Thu Jan 28 07:01:35 CST 2021, time=2021-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1406016, encodeId=0205140601694, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Wed Jan 27 12:46:51 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920165, encodeId=5353920165a2, content=肠道内存在着粘膜免疫系统,其对病原体和无害共生菌以及食物抗原提供平衡反应,从而限制不必要的炎症及其引起的组织损伤。, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4gCIdSaEkahCNuUWZv4iaKmqvUKHyKnBiarBM9RStQKBeV5Lh6GYYFiamdV5KlSfbLvmAgZTLtq81XA/0, createdBy=13511650672, createdName=言西早, createdTime=Tue Jan 26 23:14:26 CST 2021, time=2021-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920030, encodeId=d8d89200303f, content=学了, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210126/c01d15dc60f14ae8b30d0c00821d6ff5/fdcf111ae0f44884942a2902f856c367.jpg, createdBy=de5a5455674, createdName=来了, createdTime=Tue Jan 26 16:45:38 CST 2021, time=2021-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920015, encodeId=59b192001570, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=95901993306, createdName=1e1ad8bdm04(暂无匿称), createdTime=Tue Jan 26 16:01:26 CST 2021, time=2021-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919864, encodeId=8cc09198647b, content=IBS由肥大细胞激活诱导的疾病, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210125/b2bad80c90f1401091d00323c96bfb01/ef4aae86b90a4b3992bf86be9eb98d69.jpg, createdBy=f0062359976, createdName=koo!, createdTime=Mon Jan 25 22:09:38 CST 2021, time=2021-01-25, status=1, ipAttribution=)]
    2021-01-26 言西早

    肠道内存在着粘膜免疫系统,其对病原体和无害共生菌以及食物抗原提供平衡反应,从而限制不必要的炎症及其引起的组织损伤。

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1884928, encodeId=048c1884928ff, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Wed Sep 22 00:46:51 CST 2021, time=2021-09-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=921031, encodeId=64a792103173, content=有可能 局部过敏, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2018/11/07/32f6eeca95f16df602e2fe81e7416090.jpg, createdBy=ddb32421444, createdName=精气神, createdTime=Fri Jan 29 13:49:02 CST 2021, time=2021-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920497, encodeId=6cfa92049e40, content=好方向, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210127/50a003c4097845e182c08afd64d8a509/bd766dfebe9c40e0bca2dae964601bdc.jpg, createdBy=22de5454917, createdName=carrotlyl, createdTime=Thu Jan 28 07:01:35 CST 2021, time=2021-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1406016, encodeId=0205140601694, content=<a href='/topic/show?id=a5404e589d7' target=_blank style='color:#2F92EE;'>#局部#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47589, encryptionId=a5404e589d7, topicName=局部)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d14c2562456, createdName=chg122, createdTime=Wed Jan 27 12:46:51 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920165, encodeId=5353920165a2, content=肠道内存在着粘膜免疫系统,其对病原体和无害共生菌以及食物抗原提供平衡反应,从而限制不必要的炎症及其引起的组织损伤。, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4gCIdSaEkahCNuUWZv4iaKmqvUKHyKnBiarBM9RStQKBeV5Lh6GYYFiamdV5KlSfbLvmAgZTLtq81XA/0, createdBy=13511650672, createdName=言西早, createdTime=Tue Jan 26 23:14:26 CST 2021, time=2021-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920030, encodeId=d8d89200303f, content=学了, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210126/c01d15dc60f14ae8b30d0c00821d6ff5/fdcf111ae0f44884942a2902f856c367.jpg, createdBy=de5a5455674, createdName=来了, createdTime=Tue Jan 26 16:45:38 CST 2021, time=2021-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920015, encodeId=59b192001570, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=95901993306, createdName=1e1ad8bdm04(暂无匿称), createdTime=Tue Jan 26 16:01:26 CST 2021, time=2021-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=919864, encodeId=8cc09198647b, content=IBS由肥大细胞激活诱导的疾病, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210125/b2bad80c90f1401091d00323c96bfb01/ef4aae86b90a4b3992bf86be9eb98d69.jpg, createdBy=f0062359976, createdName=koo!, createdTime=Mon Jan 25 22:09:38 CST 2021, time=2021-01-25, status=1, ipAttribution=)]
    2021-01-26 来了

    学了

    0

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    2021-01-26 1e1ad8bdm04(暂无匿称)

    学习了

    0

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    2021-01-25 koo!

    IBS由肥大细胞激活诱导的疾病

    0

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