JAHA:2型糖尿病患者微血管疾病与心衰发生率

2021-06-11 MedSci原创 MedSci原创

在调整其他已知危险因素后,MVD与2型糖尿病患者的HF风险增高相关。该研究的结果强调了MVD对糖尿病相关HF发展的作用。

血管疾病(MVD)是糖尿病相关心功能障碍发病机制的潜在促进因素。然而,关于2型糖尿病患者微血管密度与心衰(HF)之间相关性的数据十分匮乏。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员旨在探究成年2型糖尿病患者MVD与HF之间的相关性。

在前瞻性糖尿病健康行动(AHEAD)研究中,4095名无心衰的2型糖尿病参与者被评估为糖尿病相关的MVD,包括肾病、视网膜病变或神经病变。研究人员使用医院和死亡记录对心衰事件进行前瞻性评估和判定。Cox模型用于获得HF的危险比和95%CI。

不同MVD类型的HF风险

4095名参与者中,34.8% (n=1424)参与者患有MVD,定义为基线时伴有肾病、视网膜病变或神经病变中的一种。在9.7年的中位时间里,发生117例HF事件。在校正相关混杂因素后,MVD患者发生心衰的风险比无MVD患者高2.5倍(风险比为2.54;95%CI为1.73-3.75)。在对冠状动脉疾病进行额外调整后,这种相关性仍然显著(风险比为2.42;95%CI为1.64-3.57)。根据MVD的类型,HF的风险比分别为2.22 (95%CI为1.51-3.27)、1.30 (95%CI为0.72-2.36)和1.33 (95%CI为0.86-2.07)。

由此可见,在调整其他已知危险因素后,MVD与2型糖尿病患者的HF风险增高相关。该研究的结果强调了MVD对糖尿病相关HF发展的作用

原始出处:

Arnaud D. Kaze.et al.Microvascular Disease and Incident Heart Failure Among Individuals With Type 2 Diabetes Mellitus.J AM HEART ASSOC.2021.https://doi.org/10.1161/JAHA.120.018998

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    2021-06-12 SR~young海东

    糖尿病,富贵病。

    0

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    2021-06-12 zhaohui6731
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GetPortalCommentsPageByObjectIdResponse(id=1043641, encodeId=02a210436417d, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Fri Jun 11 03:36:33 CST 2021, time=2021-06-11, status=1, ipAttribution=)]
    2021-06-12 mgqwxj
  5. [GetPortalCommentsPageByObjectIdResponse(id=1826697, encodeId=67fe182669e65, content=<a href='/topic/show?id=e5283e89970' target=_blank style='color:#2F92EE;'>#发生率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37899, encryptionId=e5283e89970, topicName=发生率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Mon Jul 12 23:36:33 CST 2021, time=2021-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=973079, encodeId=0f549e3079be, content=糖尿病,富贵病。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210313/9df56058b3964a8cac82563f95f0389d/c1b478592e8e4463bef44d32712e98fd.jpg, createdBy=ea905324251, createdName=SR~young海东, createdTime=Sat Jun 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  6. [GetPortalCommentsPageByObjectIdResponse(id=1826697, encodeId=67fe182669e65, content=<a href='/topic/show?id=e5283e89970' target=_blank style='color:#2F92EE;'>#发生率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37899, encryptionId=e5283e89970, topicName=发生率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Mon Jul 12 23:36:33 CST 2021, time=2021-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=973079, encodeId=0f549e3079be, content=糖尿病,富贵病。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210313/9df56058b3964a8cac82563f95f0389d/c1b478592e8e4463bef44d32712e98fd.jpg, createdBy=ea905324251, createdName=SR~young海东, createdTime=Sat Jun 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  7. [GetPortalCommentsPageByObjectIdResponse(id=1826697, encodeId=67fe182669e65, content=<a href='/topic/show?id=e5283e89970' target=_blank style='color:#2F92EE;'>#发生率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37899, encryptionId=e5283e89970, topicName=发生率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Mon Jul 12 23:36:33 CST 2021, time=2021-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=973079, encodeId=0f549e3079be, content=糖尿病,富贵病。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210313/9df56058b3964a8cac82563f95f0389d/c1b478592e8e4463bef44d32712e98fd.jpg, createdBy=ea905324251, createdName=SR~young海东, createdTime=Sat Jun 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  8. 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  9. [GetPortalCommentsPageByObjectIdResponse(id=1826697, encodeId=67fe182669e65, content=<a href='/topic/show?id=e5283e89970' target=_blank style='color:#2F92EE;'>#发生率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37899, encryptionId=e5283e89970, topicName=发生率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Mon Jul 12 23:36:33 CST 2021, time=2021-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=973079, encodeId=0f549e3079be, content=糖尿病,富贵病。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210313/9df56058b3964a8cac82563f95f0389d/c1b478592e8e4463bef44d32712e98fd.jpg, createdBy=ea905324251, createdName=SR~young海东, createdTime=Sat Jun 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    2021-06-12 weigq

    微血管改变是‖型糖尿病影响全身各器官功能的最主要基础,当然会对心衰有影响。

    0

  10. 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    2021-06-11 misszhang

    谢谢MedSci提供最新的资讯

    0

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编者按:梅斯医学将定期进行汇总,帮助大家概览心血管领域最新进展。下面是呈现给大家的最近一期的神经进展。enjoy~

JAHA:老年人白天小睡与心衰的关系

更长和更频繁的日间小睡可导致未来HF风险升高,未来的研究需要明确潜在的机制。

JAHA:外周动脉疾病患者心衰与结局的关联

外周动脉疾病 (PAD) 和心力衰竭 (HF) 均与不良结局独立相关。原发性PAD患者与新发HF相关的危险因素尚未明确。此外,HF是否与PAD患者结局之间存在相关性也尚未明确。