Nutrition 2021速递:孕期保持健康的研究结果公布

2021-06-08 Sunny MedSci原创

速递一览!

近期在线召开的NUTRITION 2021 LIVE ONLINE上发表的四项新研究着眼于补充剂​​、饮食习惯和体育活动如何影响怀孕期间健康的各个方面。现梅斯医学整理了四篇汇报的主要内容供大家参考学习。

  • 产前补充剂可能会影响母乳的菌群组成

母乳含有一种独特的细菌混合物——称为微生物群——对儿童健康起着重要作用。在一项新研究中,普渡大学的研究人员检查了 771 名参加儿童队列研究的母亲的产前饮食或补充剂是否影响母乳中的微生物群。分析表明,补充剂与人乳微生物群组成的变化有关,但与饮食模式无关。怀孕期间服用鱼油或叶酸补充剂的母亲的微生物多样性低于未服用者,而服用维生素 C 的母亲的微生物多样性高于未服用者。研究人员表示,需要更多的分析来解释可能影响母乳微生物组的其他变量。

母乳微生物群在儿童健康中起着重要作用,并受多种因素的影响。我们旨在检查产前饮食和补充剂摄入量是否与母乳微生物群组成有关。

在 CHILD Cohort Study 成员中,771 位母亲提供了怀孕期间饮食和补充剂摄入量的数据以及产后 2-6 个月期间的牛奶样本。使用改编自 Fred Hutchinson 癌症中心的食物频率问卷评估母亲的饮食。使用主成分分析得出三种饮食模式:基于植物的、西方的和平衡的。使用 16S rRNA 基因测序分析了牛奶微生物组。使用针对多重比较调整的 Wilcoxon 符号秩检验,在 R 中检查了母体摄入量与微生物多样性(香农指数)和属相对丰度之间的关联。

母亲补充剂的摄入量,而不是饮食模式,与母乳微生物群的组成有关。大约 88% 的母亲服用了产前多种维生素。怀孕期间服用鱼油 (18%) 或叶酸补充剂 (17%) 的母亲的微生物多样性低于未服用的母亲(平均±标准差:1.61 ±0.64 vs. 1.79 ±0.66 鱼油 [p=0.01] 和 1.64 ±0.64 与 1.78 ±0.67 叶酸 [p=0.02])。谁把维生素C补充剂(4%)相比,那些谁没有母亲,具有较高的微生物多样性(1.99±0.59诉1.72±0.65 [P = 0.03])和较高的相对丰度的 小韦荣 但低丰度 Finegoldia和嗜(p fdr< 0.05)。与相应的不服用补充剂的母亲相比,服用维生素 D 补充剂的母亲 (23%) 的未分类菊苣 科的 丰度较低(p fdr < 0.05),而服用含钙抗酸剂的母亲 (11%) 的链球菌丰度更高 ,未分类的 Gemellaceae和 Rothia, 但未分类的 Comamonadaceae 和未分类的 肠杆菌科的 丰度较低(p fdr < 0.05)。

母乳中微生物群的组成在服用特定产前补充剂的母亲之间存在差异。需要进一步分析以探索其他关联,同时考虑影响母乳微生物组的协变量。

  • 关于母亲肥胖如何影响儿童的新见解

尽管已知母亲肥胖会影响后代的健康,但科学家们仍在努力了解为什么这种影响并不总是一致的。Pennington 生物医学研究中心的研究人员研究了 22 位患有肥胖症的母亲,这些母亲有或没有其他代谢综合征风险因素,包括高血糖或高胆固醇。他们发现,尽管怀孕期间体重增加和总脂肪量增加的水平相似,但与没有危险因素的妇女相比,具有额外危险因素的妇女往往具有更高的血糖水平。与没有额外风险因素的母亲所生的后代相比,具有额外风险因素的母亲所生的后代体重更重,脂肪量也更多。这些结果表明,代谢不健康的肥胖会导致长期暴露于较高水平的葡萄糖和甘油三酯,从而促进后代出生时的脂肪量和体重增加。研究结果还将肥胖和其他危险因素的女性确定为可以从产前干预中受益的群体。

孕产妇肥胖会增加不良妊娠和后代结局的风险;然而,具有很大的异质性。我们假设在肥胖的母亲中,后代肥胖的异质性是由于长期暴露于过量的母体底物,即葡萄糖和甘油三酯,它们促进胎儿脂肪的增加。这项前瞻性观察研究的目的是:1)检查代谢不健康肥胖(MUO)和代谢健康肥胖(MHO)孕妇的母体代谢环境;2) 确定肥胖女性的这些母体代谢表型是否会影响婴儿肥胖。

在妊娠早期,51 名肥胖女性根据代谢综合征 (SBP >130) 的零 (MHO) 或 ≥2 (MUO) 危险因素被归类为 MUO (n=9) 或 MHO (n=13)或 DBP >85、HDL < 50 mg/dL、LDL≥100 mg/dL、甘油三酯 ≥150 mg/dL 和葡萄糖 ≥100 mg/dL)。从早期(13-16 周)、中期(24-27 周)到晚期(35 周)葡萄糖和甘油三酯的妊娠浓度曲线下面积 (AUC)、妊娠体重增加 (GWG)、脂肪增加和能量摄入和消耗37 wks) 比较两组之间的妊娠和婴儿脂肪量。

与患有 MHO 的女性相比,患有 MUO 的女性在母亲的 BMI、GWG、脂肪堆积、能量和常量营养素摄入量以及能量消耗方面没有差异。在两组中,母体底物从妊娠 13 周到 37 周的变化相似,但 MUO 导致葡萄糖(+2169.7 ± 381.5 p < 0.001 mg/dL·天)和甘油三酯(+12210.5 ± 3916.1 mg/ dL·天,p < 0.001)。MHO 女性的后代出生体重 (-620.8 ± 204.6 g,  p = 0.01)、体脂百分比 (-5.8 ± 2.1 %,  p = 0.02) 和总脂肪量 (-268.8 ± 88.4 g,  p = 0.01)。

怀孕期间不同的肥胖表型可以解释后代肥胖的异质性。代谢不健康的肥胖导致胎儿脂肪促进底物的暴露时间更长,出生时肥胖增加。该研究确定了最需要产前干预的肥胖女性人群,并建议在评估干预对后代结果的影响时需要考虑肥胖表型。

  • 怀孕期间的体力活动与表观遗传变化有关

怀孕前和怀孕期间的体力活动 (PA) 可能会通过胎盘中的表观遗传修饰影响后代的健康。先前的研究在怀孕期间进行了单一的 PA 评估,这限制了考虑怀孕期间 PA 变化的能力。我们假设 PA 的时间可能与差异甲基化有关,并评估了 PA 的多次评估与胎盘中全基因组甲基化变化之间的关联。

在分娩时获得胎盘组织,并使用 Illumina Human Methylation450 Beadchip 为 NICHD 胎儿生长研究–单身队列中的 301 位母亲测量 DNA 甲基化。使用针对 8-13(访问 0)、16-22(访问 1)、24-29(访问 2)、30-33(访问 3)、妊娠 34-37(第 4 次就诊)、38-41(第 5 次就诊)周。对于每次访问时 PA 与甲基化的关联,我们对潜在的混杂因素进行了线性回归调整,例如母亲年龄、种族/民族、孕前体重指数。使用 Ingenuity Pathway Analysis 查询注释重要 CpG 位点的基因(错误发现率调整 P < 0.05)以富集功能途径。

第 0 次访视前 12 个月的 PA 与甲基化无显着相关,而自上次访视 1-5 以来的 PA 分别与 1、0、2、29、30 个 CpG 位点的甲基化相关(P 值为3.07x10 -9到 3.35x10 -6)。与 PA 显着相关的 13 个 CpG 位点在访问 4 和 5 时重叠,最显着的关联位于 1-磷酸鞘氨醇受体 1 中的cg21385047(分别为S1PR1, P=3.07x10 -9,P=7.45x10 -9)。五个丰富的通路在访问 4 和 5 时重叠(P < 0.05):肌醇焦磷酸生物合成、味觉通路、胆碱生物合成 III、cAMP 介导的信号传导、G 蛋白偶联受体信号传导。

研究结果表明,怀孕期间的 PA 与可能与血管和神经系统发育/功能相关的位点的胎盘 DNA 甲基化变化有关。如果被复制,我们的研究结果可以阐明与母体 PA 相关的后代表观遗传谱变化的潜在机制。

  • 什么时候吃可能会影响怀孕期间的睡眠质量

我们进食的时间与身体的昼夜节律之间存在着众所周知的关系。马来西亚 UCSI 大学的新研究正在研究这种关系 - 称为计时营养 - 与怀孕期间的睡眠质量和褪黑激素节律之间的关系。荷尔蒙褪黑激素有助于控制我们的睡眠-觉醒周期。在这项研究中,研究人员检查了 114 名首次怀孕的女性的进餐时间、进餐频率、进食窗口、不吃早餐和夜间进食。他们发现,与早餐和午餐相比,晚餐少吃或摄入较少脂肪的女性更有可能睡眠质量较差。接近就寝时间进食与在通常的睡眠中期峰值之外发生的峰值褪黑激素水平有关。

计时营养被称为时代潮流,因为它能够同步昼夜节律。除了作为昼夜节律标志物的作用外,睡眠和褪黑激素也是最佳母婴结局的重要因素。了解妊娠期间与睡眠质量和褪黑激素节律相关的时间营养因素对于预防保健具有实际意义。因此,本研究旨在检查时间营养与睡眠质量和妊娠期间褪黑激素节律之间的关联。

在马来西亚吉隆坡随机选择的政府妇幼诊所共招募了 114 名初产妇。从临床记录中提取胎龄和孕前体重指数(BMI)。使用 3 天食物记录评估计时营养成分,包括进餐时间、进餐频率、进食窗口、不吃早餐和夜间进食。使用匹兹堡睡眠质量指数 (PSQI) 确定妊娠晚期的睡眠质量。子样本 (n=48) 在 24 小时内的 4 个时间点(9:00、15:00、21:00 和 3:00 小时)提供唾液样本用于褪黑激素测定。

参与者的平均胎龄为 33.0 (2.1) 周;13% 的人体重不足,22% 的人在怀孕前超重/肥胖。平均每日进餐频率为 4.1 (0.9)。大多数 (68%) 的饮食窗口较短(≤12 小时);25% 的人不吃早餐,19% 的人在睡前 2 小时内进食。参与者中睡眠不足的患病率为 56%。平均唾液褪黑激素水平为 19.6 (16.3) pmol/L。在调整后的线性回归模型中,晚餐期间较低的进餐频率和脂肪摄入量是睡眠质量差的重要预测因素(分别为 β=-0.266,p=0.035 和 β=-0.232,p=0.026)。接近就寝时间进食与褪黑激素末期与睡眠时钟时间的较大偏差显着相关(β=-0.339,p=0.043)。

研究结果表明,时间营养的不利特征可能导致睡眠不佳和褪黑激素相位错位。可以将时间营养成分纳入膳食干预,以改善产妇睡眠质量和昼夜节律健康。

原始出处:

1.https://www.eventscribe.net/2021/ASN/index.asp?presTarget=1678974

2.https://www.eventscribe.net/2021/ASN/index.asp?presTarget=1679138

3.https://www.eventscribe.net/2021/ASN/index.asp?presTarget=1679001

4.https://www.eventscribe.net/2021/ASN/index.asp?posterTarget=384582

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#插入话题
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  2. [GetPortalCommentsPageByObjectIdResponse(id=2004433, encodeId=659020044336e, content=<a href='/topic/show?id=54ebe8621cf' target=_blank style='color:#2F92EE;'>#结果公布#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78621, encryptionId=54ebe8621cf, topicName=结果公布)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=279b407, createdName=shanyongle, createdTime=Fri Aug 27 05:00:01 CST 2021, time=2021-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1739578, encodeId=44901e39578c3, content=<a href='/topic/show?id=8041e343504' target=_blank style='color:#2F92EE;'>#研究结果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73435, encryptionId=8041e343504, topicName=研究结果)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bbcd34536678, createdName=1249894fm84暂无昵称, createdTime=Tue Apr 26 11:00:01 CST 2022, time=2022-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1661641, encodeId=38f2166164186, content=<a href='/topic/show?id=1b3c1315481' target=_blank style='color:#2F92EE;'>#nutrition#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13154, encryptionId=1b3c1315481, topicName=nutrition)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f0d25331316, createdName=膀胱癌, createdTime=Sun May 08 09:00:01 CST 2022, time=2022-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996095, encodeId=901d9960959b, content=不错不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210615/6c117830316347b8b000f28512228eeb/c3aba4023d4643c2838707e758859e94.jpg, createdBy=30c45422721, createdName=张三哥, createdTime=Sun Jul 04 13:58:32 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=971901, encodeId=75039e19013d, content=谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210608/f68c5332fff04294b99141d8b88d3ec2/a494511dd06348b7a3b1343acc4c272c.jpg, createdBy=77075513887, createdName=ms5000001437056934, createdTime=Tue Jun 08 17:09:43 CST 2021, time=2021-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=971895, encodeId=93349e18957f, content=学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d25a5516768, createdName=一己怀, createdTime=Tue Jun 08 16:55:19 CST 2021, time=2021-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=971865, encodeId=00f79e1865fd, content=孕期保健对优生优育很关键。, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Tue Jun 08 16:07:56 CST 2021, time=2021-06-08, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=2004433, encodeId=659020044336e, content=<a href='/topic/show?id=54ebe8621cf' target=_blank style='color:#2F92EE;'>#结果公布#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78621, encryptionId=54ebe8621cf, topicName=结果公布)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=279b407, createdName=shanyongle, createdTime=Fri Aug 27 05:00:01 CST 2021, time=2021-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1739578, encodeId=44901e39578c3, content=<a href='/topic/show?id=8041e343504' target=_blank style='color:#2F92EE;'>#研究结果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73435, encryptionId=8041e343504, topicName=研究结果)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bbcd34536678, createdName=1249894fm84暂无昵称, createdTime=Tue Apr 26 11:00:01 CST 2022, time=2022-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1661641, encodeId=38f2166164186, content=<a href='/topic/show?id=1b3c1315481' target=_blank style='color:#2F92EE;'>#nutrition#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13154, encryptionId=1b3c1315481, topicName=nutrition)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f0d25331316, createdName=膀胱癌, createdTime=Sun May 08 09:00:01 CST 2022, time=2022-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996095, encodeId=901d9960959b, content=不错不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210615/6c117830316347b8b000f28512228eeb/c3aba4023d4643c2838707e758859e94.jpg, createdBy=30c45422721, createdName=张三哥, createdTime=Sun Jul 04 13:58:32 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=971901, encodeId=75039e19013d, content=谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210608/f68c5332fff04294b99141d8b88d3ec2/a494511dd06348b7a3b1343acc4c272c.jpg, createdBy=77075513887, createdName=ms5000001437056934, createdTime=Tue Jun 08 17:09:43 CST 2021, time=2021-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=971895, encodeId=93349e18957f, content=学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d25a5516768, createdName=一己怀, createdTime=Tue Jun 08 16:55:19 CST 2021, time=2021-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=971865, encodeId=00f79e1865fd, content=孕期保健对优生优育很关键。, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Tue Jun 08 16:07:56 CST 2021, time=2021-06-08, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=2004433, encodeId=659020044336e, content=<a href='/topic/show?id=54ebe8621cf' target=_blank style='color:#2F92EE;'>#结果公布#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78621, encryptionId=54ebe8621cf, topicName=结果公布)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=279b407, createdName=shanyongle, createdTime=Fri Aug 27 05:00:01 CST 2021, time=2021-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1739578, encodeId=44901e39578c3, content=<a href='/topic/show?id=8041e343504' target=_blank style='color:#2F92EE;'>#研究结果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73435, encryptionId=8041e343504, topicName=研究结果)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bbcd34536678, createdName=1249894fm84暂无昵称, createdTime=Tue Apr 26 11:00:01 CST 2022, time=2022-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1661641, encodeId=38f2166164186, content=<a href='/topic/show?id=1b3c1315481' target=_blank style='color:#2F92EE;'>#nutrition#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13154, encryptionId=1b3c1315481, topicName=nutrition)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f0d25331316, createdName=膀胱癌, createdTime=Sun May 08 09:00:01 CST 2022, time=2022-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996095, encodeId=901d9960959b, content=不错不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210615/6c117830316347b8b000f28512228eeb/c3aba4023d4643c2838707e758859e94.jpg, createdBy=30c45422721, createdName=张三哥, createdTime=Sun Jul 04 13:58:32 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=971901, encodeId=75039e19013d, content=谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210608/f68c5332fff04294b99141d8b88d3ec2/a494511dd06348b7a3b1343acc4c272c.jpg, createdBy=77075513887, createdName=ms5000001437056934, createdTime=Tue Jun 08 17:09:43 CST 2021, time=2021-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=971895, encodeId=93349e18957f, content=学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d25a5516768, createdName=一己怀, createdTime=Tue Jun 08 16:55:19 CST 2021, time=2021-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=971865, encodeId=00f79e1865fd, content=孕期保健对优生优育很关键。, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Tue Jun 08 16:07:56 CST 2021, time=2021-06-08, status=1, ipAttribution=)]
    2021-07-04 张三哥

    不错不错

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2004433, encodeId=659020044336e, content=<a href='/topic/show?id=54ebe8621cf' target=_blank style='color:#2F92EE;'>#结果公布#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78621, encryptionId=54ebe8621cf, topicName=结果公布)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=279b407, createdName=shanyongle, createdTime=Fri Aug 27 05:00:01 CST 2021, time=2021-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1739578, encodeId=44901e39578c3, content=<a href='/topic/show?id=8041e343504' target=_blank style='color:#2F92EE;'>#研究结果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73435, encryptionId=8041e343504, topicName=研究结果)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bbcd34536678, createdName=1249894fm84暂无昵称, createdTime=Tue Apr 26 11:00:01 CST 2022, time=2022-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1661641, encodeId=38f2166164186, content=<a href='/topic/show?id=1b3c1315481' target=_blank style='color:#2F92EE;'>#nutrition#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13154, encryptionId=1b3c1315481, topicName=nutrition)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f0d25331316, createdName=膀胱癌, createdTime=Sun May 08 09:00:01 CST 2022, time=2022-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996095, encodeId=901d9960959b, content=不错不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210615/6c117830316347b8b000f28512228eeb/c3aba4023d4643c2838707e758859e94.jpg, createdBy=30c45422721, createdName=张三哥, createdTime=Sun Jul 04 13:58:32 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=971901, encodeId=75039e19013d, content=谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210608/f68c5332fff04294b99141d8b88d3ec2/a494511dd06348b7a3b1343acc4c272c.jpg, createdBy=77075513887, createdName=ms5000001437056934, createdTime=Tue Jun 08 17:09:43 CST 2021, time=2021-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=971895, encodeId=93349e18957f, content=学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d25a5516768, createdName=一己怀, createdTime=Tue Jun 08 16:55:19 CST 2021, time=2021-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=971865, encodeId=00f79e1865fd, content=孕期保健对优生优育很关键。, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Tue Jun 08 16:07:56 CST 2021, time=2021-06-08, status=1, ipAttribution=)]
    2021-06-08 ms5000001437056934

    谢谢

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2004433, encodeId=659020044336e, content=<a href='/topic/show?id=54ebe8621cf' target=_blank style='color:#2F92EE;'>#结果公布#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78621, encryptionId=54ebe8621cf, topicName=结果公布)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=279b407, createdName=shanyongle, createdTime=Fri Aug 27 05:00:01 CST 2021, time=2021-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1739578, encodeId=44901e39578c3, content=<a href='/topic/show?id=8041e343504' target=_blank style='color:#2F92EE;'>#研究结果#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73435, encryptionId=8041e343504, topicName=研究结果)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=bbcd34536678, createdName=1249894fm84暂无昵称, createdTime=Tue Apr 26 11:00:01 CST 2022, time=2022-04-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1661641, encodeId=38f2166164186, content=<a href='/topic/show?id=1b3c1315481' target=_blank style='color:#2F92EE;'>#nutrition#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13154, encryptionId=1b3c1315481, topicName=nutrition)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f0d25331316, createdName=膀胱癌, createdTime=Sun May 08 09:00:01 CST 2022, time=2022-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=996095, encodeId=901d9960959b, content=不错不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210615/6c117830316347b8b000f28512228eeb/c3aba4023d4643c2838707e758859e94.jpg, createdBy=30c45422721, createdName=张三哥, createdTime=Sun Jul 04 13:58:32 CST 2021, time=2021-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=971901, encodeId=75039e19013d, content=谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210608/f68c5332fff04294b99141d8b88d3ec2/a494511dd06348b7a3b1343acc4c272c.jpg, createdBy=77075513887, createdName=ms5000001437056934, createdTime=Tue Jun 08 17:09:43 CST 2021, time=2021-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=971895, encodeId=93349e18957f, content=学到了, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d25a5516768, createdName=一己怀, createdTime=Tue Jun 08 16:55:19 CST 2021, time=2021-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=971865, encodeId=00f79e1865fd, content=孕期保健对优生优育很关键。, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Tue Jun 08 16:07:56 CST 2021, time=2021-06-08, status=1, ipAttribution=)]
    2021-06-08 一己怀

    学到了

    0

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    2021-06-08 yangchou

    孕期保健对优生优育很关键。

    0