Hypertension:高血压诊断年龄与脑结构和痴呆症之间的关联

2021-10-08 MedSci原创 MedSci原创

在青年或中年诊断出高血压,而非老年,与较小的脑容量和痴呆风险增加相关。

关于高血压与脑容量和痴呆之间的关联是否会因诊断高血压时的年龄而改变知之甚少。

近日,血管权威杂志Hypertension上发表了一篇研究文章,研究人员分析了基于英国生物银行和2006年至2010年期间收集的基线数据。2014年至2019年期间使用脑磁共振成像测量了受试者脑容量。

研究人员使用医院住院患者、死亡率和2021年之前的自我报告数据确定了痴呆症情况,并使用倾向评分按高血压诊断年龄分层,为每名高血压参与者随机选择一个对照参与者。

该队列纳入了11399名高血压患者和11399名对照者进行脑容量分析,以及纳入了124053名高血压患者和124053名对照者进行痴呆分析。在多变量分析中,高血压诊断年龄35岁以下(β(95%CI为-10.83[-19.27至-2.39]ml)、35至44岁(-6.82[-12.18至-1.46]ml)和45至54岁(-3.77[-6.91至-0.64]mL)的总脑容量小于相应的对照者。同样,在早年和中年诊断出的高血压与较小的灰质、外周皮质灰质和白质体积独立相关。中位随访11.9年,研究人员共记录了4626例全因痴呆事件。与调整协变量后的相应对照者相比,仅在35至44岁诊断出高血压的个体患全因痴呆的风险更高(风险比[95%CI]为1.61[1.31-1.99])。

由此可见,在青年或中年诊断出高血压,而非老年,与较小的脑容量和痴呆风险增加相关。

原始出处:

Xianwen Shang.et al.The Association of Age at Diagnosis of Hypertension With Brain Structure and Incident Dementia in the UK Biobank.Hypertension.2021.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.121.17608

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    2022-07-10 feather89
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    2021-12-22 Boyinsh
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    2021-10-10 wmr116
  7. [GetPortalCommentsPageByObjectIdResponse(id=1729141, encodeId=d9671e291411a, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Jul 10 03:27:56 CST 2022, time=2022-07-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836280, encodeId=34b5183628017, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Wed Dec 22 07:27:56 CST 2021, time=2021-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2039281, encodeId=d8b9203928167, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Sun Aug 28 02:27:56 CST 2022, time=2022-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1681943, encodeId=0d67168194376, content=<a href='/topic/show?id=19939159231' target=_blank style='color:#2F92EE;'>#诊断年龄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91592, encryptionId=19939159231, topicName=诊断年龄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7cf527881568, createdName=360611849, createdTime=Sun Apr 17 17:27:56 CST 2022, time=2022-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501553, encodeId=2b8d1501553f9, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Sun Oct 10 12:27:56 CST 2021, time=2021-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1556531, encodeId=8da815565312f, content=<a href='/topic/show?id=ab7e85001cf' target=_blank style='color:#2F92EE;'>#脑结构#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85001, encryptionId=ab7e85001cf, topicName=脑结构)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4f3114785325, createdName=wmr116, createdTime=Sun Oct 10 12:27:56 CST 2021, time=2021-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1246304, encodeId=27fc12463048c, content=老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Sat Oct 09 00:27:56 CST 2021, time=2021-10-09, status=1, ipAttribution=)]
    2021-10-09 neuro.Dr

    老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!

    0

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