J Periodontal Res：L-PRF和A-PRF对牙周成纤维细胞体外伤口愈合的影响

2020-04-30 网络网络

L-PRF和A-PRF+是用于牙周再生手术的自体材料，均来源于患者的血液，但特点不同，对牙周组织成纤维细胞的影响存在争议。

L-PRF和A-PRF+是用于牙周再生手术的自体材料，均来源于患者的血液，但有不同的特点，对牙周组织成纤维细胞的影响存在争议。本研究旨在测定白细胞-富血小板纤维蛋白（L-PRF）和改良型富血小板纤维蛋白（A-PRF+）在体外诱导牙周成纤维细胞增殖和迁移的能力是否存在差异。

从8名患者中制备L-PRF和A-PRF+膜，在3 mL培养基中培养2天。从7个供体中提取牙龈成纤维细胞(G-F)和牙周膜成纤维细胞(PDL-F)原代细胞。这些细胞在伤口愈合实验板中预培养1天，细胞浓度为3.3×10⁵细胞/mL，留下500±50μm的间隙。将每70ul的细胞悬浮液放入相应的孔中。将预培养的L-PRF和A-PRF+上清液加入其中，并将成纤维细胞再培养24 h，单独培养基（NEG）和成纤维细胞生长因子II（FGF）作为对照。随后，用活细胞成像技术检测24小时内，在37℃、5％CO₂条件下细胞的迁移情况。检测细胞增殖和细胞活力。

实验结果：与FGF和NEG相比，在L-PRF和A-PRF+诱导下，细胞增殖速度更快。与对照组相比，A-PRF +和L-PRF诱导的人工伤口愈合速度明显快于对照组。在初始阶段，两种PRF组均诱导了较快的细胞迁移（P < .01），但在停止阶段，A-PRF+组比L-PRF组诱导的迁移率更高（P < .01）。

因此，L-PRF和A-PRF+对牙周成纤维细胞的迁移和增殖均有促进作用，并且，A-PRF+对人工伤口愈合的维持作用比L-PRF久。

原文出处：

Luciano Pitzurra， Effects of L‐PRF and A‐PRF+ on periodontal fibroblasts in in vitro wound healing experiments， journal of periodontal research， 2020， doi.org/10.1111/jre.12714

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2020-10-24 feather89

#PE#

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2021-04-15 fengyqf

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2020-05-02 zhouqu_8

#成纤维细胞#

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2020-05-02 chenzhuanggui

#伤口愈合#

38 0
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2020-05-02 医者仁心

#牙周#

28 0
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2020-05-02 marongnuan

#纤维细胞#

27 0
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2020-05-02 12498b3em13(暂无昵称)

#PRF#

26 0

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