Stroke:肝移植患者术后房颤与卒中的长期风险的关系

2020-12-24 MedSci原创 MedSci原创

LT后的POAF与血栓栓塞事件风险增加8倍相关,使用CHA2DS2VASc评分可能有助于这些患者的风险分层。必须进行前瞻性研究,以评估使用口服抗凝剂是否可以降低LT后血栓栓塞的风险。

术后房颤(POAF)是肝移植(LT)后最常见的血管并发症。近日,心血管疾病领域权威杂志Stroke上发表了一篇研究文章,这项研究旨在评估LT患者POAF与随后血栓栓塞事件之间可能的关联。

研究人员进行了一项回顾性队列研究,研究对象为2010年至2018年之间接受LT的成年人。如果既往无AF病史,但在LT后30天内发生房颤(AF),则将患者分类为POAF。缺血性卒中或全身性栓塞病例由两名医师组成的小组进行裁决。

该研究纳入了461名患者,47名(10.2%)患者移植后中位时间为3天发生了POAF。POAF的独立预测因素包括年龄增长、术后败血症和左心房扩大。在4.9年(四分位间距为2.9-7.2)的中位随访期内,21名患者发生了卒中和全身性栓塞。POAF患者的血栓栓塞事件发生率明显更高(17.0% vs. 3.1%;P<0.001)。调整后,POAF仍是血栓栓塞事件的独立预测因子(风险比为8.36 [95%CI为2.34–29.79])。CHA2DS2VASc评分的增加也是血栓栓塞事件的独立预测因子(风险比为1.58 [95%CI为1.02-2.46])。仅使用POAF和CHA2DS2VASc得分≥2的模型可得到C统计量为0.77,并对血栓栓塞事件的预测进行了适当的校准。但是,POAF并不是长期死亡率的独立预测因素。

由此可见,LT后的POAF与血栓栓塞事件风险增加8倍相关,使用CHA2DS2VASc评分可能有助于这些患者的风险分层。必须进行前瞻性研究,以评估使用口服抗凝剂是否可以降低LT后血栓栓塞的风险。

原始出处:

Anoop N. Koshy.et al.Postoperative Atrial Fibrillation and Long-Term Risk of Stroke in Patients Undergoing Liver Transplantation.stroke.2020.https://www.ahajournals.org/doi/10.1161/STROKEAHA.120.031454

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    2020-12-25 Jessie Zhang

    肝移植患者术后房颤与卒中的长期风险的关系

    0

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    2020-12-24 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1820435, encodeId=6a1318204355e, content=<a href='/topic/show?id=c87f10089032' target=_blank style='color:#2F92EE;'>#风险的关系#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100890, encryptionId=c87f10089032, topicName=风险的关系)], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/cc81592b507031e3cfd8d4c57911d98b/62c22832a9474aea1ca90ca058aebc03.jpg, createdBy=bed5446, createdName=limedical1974, createdTime=Thu Mar 11 20:47:26 CST 2021, time=2021-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2066840, encodeId=7739206684057, content=<a href='/topic/show?id=fe1a6106394' target=_blank style='color:#2F92EE;'>#术后房颤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61063, encryptionId=fe1a6106394, topicName=术后房颤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=24a22500182, createdName=1696533704_45270454, createdTime=Mon Feb 08 19:47:26 CST 2021, time=2021-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401350, encodeId=18531401350de, content=<a href='/topic/show?id=80e89e0479a' target=_blank style='color:#2F92EE;'>#长期风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97047, encryptionId=80e89e0479a, topicName=长期风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat Dec 26 09:47:26 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910795, encodeId=1c42910e9583, content=肝移植患者术后房颤与卒中的长期风险的关系, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201120/5008534db22c474a844fbd107ff83af2/d3e20fc133b542208ff15e7f2b575329.jpg, createdBy=c7015311102, createdName=Jessie Zhang, createdTime=Fri Dec 25 09:16:48 CST 2020, time=2020-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026731, encodeId=bc8b1026e31c1, content=卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Thu Dec 24 21:47:26 CST 2020, time=2020-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031330, encodeId=b43f1031330b4, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Thu Dec 24 21:47:26 CST 2020, time=2020-12-24, status=1, ipAttribution=)]
    2020-12-24 心介

    房颤,临床上碰到很多哦

    0

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