Lancet respir med:俯卧位呼吸对新冠肺炎患者血氧饱和度的影响

2020-06-23 MedSci原创 MedSci原创

对于需接受吸氧的新冠肺炎患者,俯卧位呼吸干预可快速改善血氧饱和度,但不能降低患者的插管率

COVID-19大流行导致出现大量的需插管治疗的呼吸衰竭患者,统计发现俯卧位呼吸可降低中重度急性呼吸窘迫综合征患者的死亡率。近日研究人员考察了对清醒、非插管的Covid-19肺炎患者进行俯卧定位呼吸治疗的可行性和效果。
 
研究在意大利开展,18-75岁的COVID-19相关肺炎患者接受了吸氧或无创持续气道正压通气治疗,收集了患者人口统计、人体测量学、动脉血气和通气参数的基线数据。 在基线数据收集后,帮助患者进入俯卧位,维持至少3小时。在俯卧定位后10分钟和回到仰卧位后1小时重新收集上述数据。主要研究结果是在基线检查和干预后氧合(氧分压[PaO2]/吸入空气中氧分浓度[FiO2])数据变化。
 
56名患者参与研究,其中44名(79%)为男性,平均年龄为57.4岁,平均体重指数为27.5 kg/m2。对47例患者(83.9%)干预发现,采用俯卧位是可行的(即至少维持3h)。从仰卧位到俯卧位,氧合数据明显改善(仰卧位PaO2/FiO2比值180.5mm Hg,俯卧位285.5mm Hg)。体位恢复后氧疗后,23例患者的氧合状况得到改善(50.0%),但不显著(1h的PaO2/FiO2比值为192.9mmHg)。维持氧合增加的患者炎症标志物水平升高(C反应蛋白:12.7 mg/L vs8.4 mg/L ;血小板:241.1×103/μL vs 319.8×103/μL)。46名患者中有13名(28%)最终插管,体位干预应答者7名(30%),无应答者中有6名(26%)。
 
研究认为,对于需接受吸氧的新冠肺炎患者,俯卧位呼吸干预可快速改善血氧饱和度,但不能降低患者的插管率。
 
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    2020-10-01 howi
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    2020-06-25 lqvr
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    2020-06-23 公卫新人

    新冠肺炎,疫情何时才能消失

    0

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    2020-06-23 goodbing

    顶刊就是不一样,质量很高,内容精彩!学到很多

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