JNCI:根治幽门螺杆菌可以降低胃癌风险

2016-09-21 Seven L 译 MedSci原创

幽门螺杆菌与胃腺癌和胃黏膜相关淋巴组织(MALT)淋巴瘤风险的增加有关;幽门螺杆菌还与食管腺癌风险的降低有关。我们的目的是评估,根除治疗幽门螺杆菌后,对这些癌症风险的影响。 我们检索了PubMed、Web of Science、EMBASE和Cochrane图书馆等数据库,纳入探讨胃癌、MALT淋巴瘤或食管癌风险的研究(根治幽门螺杆菌 vs 不根治),合并后进行系统回顾和荟萃分析。 从

幽门螺杆菌与胃腺癌和胃黏膜相关淋巴组织(MALT)淋巴瘤风险的增加有关;幽门螺杆菌还与食管腺癌风险的降低有关。我们的目的是评估,根除治疗幽门螺杆菌后,对这些癌症风险的影响。

我们检索了PubMed、Web of Science、EMBASE和Cochrane图书馆等数据库,纳入探讨胃癌、MALT淋巴瘤或食管癌风险的研究(根治幽门螺杆菌 vs 不根治),合并后进行系统回顾和荟萃分析。

从3629篇文章中筛选出9篇进行系统回顾和荟萃分析,8项队列研究评估了根治幽门螺杆菌对胃癌风险的影响,1项随机研究评估了根治幽门螺杆菌对食管癌风险的影响。

12 899名成功根治幽门螺杆菌的患者中,119 (0.9%)名发展为胃癌;而18 654名非根治患者中,208 (1.1%)名发展为胃癌。将8项关于胃癌风险研究的数据进行合并,分析得出,根治幽门螺杆菌可以降低胃癌风险(与对照组相比,胃癌RR =0.46;95% CI 0.32 to 0.66, I2 = 32.3%)。对随访时间和混杂因素校正了的4篇文章合并后,根治幽门螺杆菌 vs 对照组,胃癌RR =0.46 ;95% CI = 0.29 to 0.72, I2 = 44.4%。

本系统回顾和荟萃分析表明,根除幽门螺杆菌的治疗可以预防胃癌的发生。关于根治幽门螺杆菌对MALT淋巴瘤或食管癌风险影响的相关研究数量不足,因此没有进行荟萃分析。

原始出处:

Doorakkers E.et al.Eradication of Helicobacter pylori and Gastric Cancer: A Systematic Review and Meta-analysis of Cohort Studies.J Natl Cancer Inst. 2016 Jul 14;108(9). pii: djw132. doi: 10.1093/jnci/djw132. Print 2016 Sep.

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    2017-01-18 sjq027
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    2016-10-23 kcb069
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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Wed Sep 21 21:32:00 CST 2016, time=2016-09-21, status=1, ipAttribution=)]
    2016-10-19 jyzxjiangqin

    根治幽门螺杆菌可以降低胃癌风险。

    0

  5. 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Wed Sep 21 21:32:00 CST 2016, time=2016-09-21, status=1, ipAttribution=)]
    2016-10-09 jyzxjiangqin

    许多年前许多论文皆是这样讲的。

    0

  6. 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Wed Sep 21 21:32:00 CST 2016, time=2016-09-21, status=1, ipAttribution=)]
    2016-09-23 187清风

    厉害,学习了

    0

  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Wed Sep 21 21:32:00 CST 2016, time=2016-09-21, status=1, ipAttribution=)]
    2016-09-23 187清风

    继续学习

    0

  8. 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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Wed Sep 21 21:32:00 CST 2016, time=2016-09-21, status=1, ipAttribution=)]
    2016-09-23 jeanqiuqiu
  9. 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    2016-09-21 为啥子

    以证据为基础的循证医学

    0

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    2016-09-21 医路开来

    这项技术要提高

    0

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