Heart:急性冠脉综合征恢复期肌钙蛋白水平仍可预测患者死亡风险

2019-11-11 不详 MedSci原创

高敏肌钙蛋白检测常用于急性冠脉综合征的诊断,但其在冠心病恢复期的作用尚不清楚。本研究的目的旨在研究急性冠状动脉综合征后一系列恢复期高敏心肌肌钙蛋白浓度的长期预后意义。在本次包含2140名急性冠脉综合征的前瞻性多中心观察研究中,我们对1776名患者进行了心脏肌钙蛋白I水平的检测,主要终点事件是心血管死亡事件。发病后4个月的肌钙蛋白浓度在99%的患者中是可检测的(年龄67±12岁,男性占72%),有4

高敏肌钙蛋白检测常用于急性冠脉综合征的诊断,但其在冠心病恢复期的作用尚不清楚。本研究的目的旨在研究急性冠状动脉综合征后一系列恢复期高敏心肌肌钙蛋白浓度的长期预后意义。


在本次包含2140名急性冠脉综合征的前瞻性多中心观察研究中,我们对1776名患者进行了心脏肌钙蛋白I水平的检测,主要终点事件是心血管死亡事件。发病后4个月的肌钙蛋白浓度在99%的患者中是可检测的(年龄67±12岁,男性占72%),有44.8%的患者浓度小于平均值(5ng/L),有9.3%的患者浓度大于第99百分位。经过平均4.8年时间的随访,有202名患者出现心源性死亡,经变量分析调整后,肌钙蛋白是心源性死亡的独立预测因素(HR 1.4, 95%CI 1.3-1.5),在12个月浓度还高的患者中风险最大。发病后4个月,与肌钙蛋白水平≤5ng/L的患者相比,肌钙蛋白水平>第99百分位的患者死亡风险明显更高。


研究结果显示,对于急性冠脉综合征患者,恢复期的肌钙蛋白水平仍旧可以预测患者的死亡风险。


原始出处:

Philip D et al.Convalescent troponin and cardiovascular death following acute coronary syndrome.Heart.2019 Nov.


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    2019-11-13 zhaojie88
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    2019-11-13 slcumt
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    2019-11-12 医救仁心

    恢复期的肌钙蛋白对患者病情最后还有预测价值,这个观点比较新,值得学习!

    0

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    2019-11-11 1ddf0692m34(暂无匿称)

    学习了,谢谢分享

    0

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NAT MED:运动通过造血祖细胞减少炎症细胞的产生和心血管炎症

已有的研究显示,久坐的生活方式,慢性炎症和白细胞增多会增加动脉粥样硬化的风险。然而,至今为止,我们尚不清楚正常的体育锻炼是否会影响白细胞的产生。