撸猫有风险!抗体鸡尾酒REGN1908-1909治疗猫过敏性轻度哮喘,II期研究取得阳性结果

2021-03-01 Allan MedSci原创

该试验达到了预防早期哮喘反应的主要终点(EAR,定义为一秒钟内强制呼气量下降≥20%[FEV1])。

猫诱发的过敏主要是由于暴露于Fel d 1引起的,Fel d是所有猫皮屑中的主要过敏原。Fel d 1粘附在衣服、地毯和家具上,通过空气传播扩散到周围环境中。患者通常会经历轻度至重度症状的快速发作,这些症状包括鼻塞、眼睛发痒、胸部紧绷和喘息。

目前,用抗组胺药和鼻内皮质类固醇治疗猫诱发的过敏性鼻炎,但疗效不佳。过敏原特异性免疫疗法需要12到24个月才能见到临床效果,并禁止用于患有严重或无法控制的哮喘患者。重要的是,猫过敏与哮喘之间的关联非常重要,因为超过50%的猫过敏患者并存哮喘。尽管很少见,但这些患者的猫过敏可能会引发威胁生命的哮喘发作,并导致住院治疗。

制药公司Regeneron近日公布了一项II期概念验证试验的详细结果,该试验评估了研究性抗体鸡尾酒REGN1908-1909治疗轻度哮喘猫过敏患者的有效性。该试验达到了预防早期哮喘反应的主要终点(EAR,定义为一秒钟内强制呼气量下降≥20%[FEV1])。该试验还达到了关键的次要终点,包括改善肺功能和增加单剂治疗后患者可以耐受的猫过敏原量。这些结果以口头报告形式分享在2021年美国过敏、哮喘和免疫学学会(AAAAI)年会上。

REGN1908-1909是两种全人源单克隆IgG抗体的混合物,旨在特异性结合并阻断Fel d 1过敏原,从而防止其结合并触发引起过敏的内源性抗体(例如,免疫球蛋白E)。REGN1908-1909是使用Regeneron专有的VelocImmune®技术开发的。

 

原始出处:

https://www.firstwordpharma.com/node/1804879?tsid=4

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    2021-03-12 小孔医生

    Feld1为猫皮屑的主要过敏原 超过百分之五十对猫过敏都有哮喘 抗体鸡尾酒可治疗猫过敏性轻度哮喘 这种疗法根本原因防止自己内源性免疫(球蛋白E)

    0

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    2021-03-03 qblt
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    2021-03-01 科研科研科研

    超过50%的猫过敏者存在哮喘

    0

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SMD能降低炎性因子如IgE、CRP、IL-4、IL-6,减轻OVA诱导的肺组织病理变化。同时,SMD能抑制MyD88/IKK/NF-κB信号通路,是其治疗哮喘的重要机制。

JAMA子刊:生命早期暴露于空气污染与儿童哮喘累积发病率

生命早期的空气污染与儿童早期和中期哮喘发病率增加相关,特别是在城市社区中生活、面临较少机会和资源以及多重环境共同暴露的边缘化家庭中风险更高。

World Allergy Organ J:现实世界中成年哮喘患者的慢性鼻窦炎诊断生物标志物有哪些?

研究人员开发了生物标志物来预测成年哮喘患者的 CRS。结果发现,periostin、DPP10 和 AERD 表型是预测成人哮喘患者 CRS 的重要生物标志物。

ATVB 中国医学科学院基础医学研究所赵红梅/王婧教授团队与北京协和医院刘暴教授、北京医院安琦教授揭示哮喘加重动脉粥样硬化新机制

研究揭示了经IgE刺激后的肥大细胞通过“外泌体-环RNA CDR1as-内皮细胞”途径介导哮喘加重动脉粥样硬化的机制,为哮喘合并动脉粥样硬化人群的干预提供了新思路。

WJO:胎儿肺部生长可用于预测儿童期呼吸道感染和哮喘的风险

研究表明,超声监测胎儿肺部生长可以预测儿童早期呼吸道感染和哮喘的风险。

夜班麻醉遭遇术中哮喘发作,一起学习一下临床表现以及处置

对采用区域麻醉或肌松药者如果出现通气困难,需要鉴别是支气管痉挛引起,还是呼吸肌紧张或咳嗽所致。