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J Periodontal Res：基质金属蛋白酶-7在牙周炎合并2型糖尿病中的作用

2018-10-02 MedSci MedSci原创

MMP7牙周炎糖尿病
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已经在2型糖尿病（T2DM）患者的血清样品和牙周炎患者的牙龈组织中观察到升高的基质金属蛋白酶-7（MMP7）水平。本研究的目的是收集MMP7在T2DM与全身性牙周炎（GP）之间相互作用中的作用的证据。

已经在2型糖尿病（T2DM）患者的血清样品和牙周炎患者的牙龈组织中观察到升高的基质金属蛋白酶-7（MMP7）水平。本研究的目的是收集MMP7在T2DM与全身性牙周炎（GP）之间相互作用中的作用的证据。

方法：在患有T2DM（T2DM / GP，n = 11）的GP患者的牙龈组织，患有GP的全身健康患者（n = 7）以及全身和牙周健康对照（n = 11）中对MMP7表达和定位的程度进行免疫组织化学分析。建立计算机网络模型以确定MMP7和T2DM途径之间的相互作用。在小鼠MMP7敲除模型中分析MMP7对嗜中性粒细胞迁移的调节。

结果：在人牙龈组织中，与对照组相比，MMP7稳定表达的细胞在T2DM / GP患者中的比例升高（P = .014）。根据计算机模拟分析，“羟基自由基”和“过氧化氢”化合物是网络中最重要的节点之一，并且在连接“葡萄糖”和“MMP7”的最短路径内。与野生型小鼠相比，MMP7敲除小鼠的牙龈上皮中有中性粒细胞的强烈累积（P = 0.0001）。

T2DM / GP患者牙龈组织中MMP7表达升高与高血糖引起的活性氧激活有关。抑制MMP7表达导致牙龈中性粒细胞迁移受损。

原始出处：

F. Zeidan‐Chulia， et al.糖尿病（T2DM）患者的血清样品和牙周炎患者的牙龈组织中观察到升高的基质金属蛋白酶-7（MMP7）水平。本研究的目的是收集MMP7在T2DM与全身性牙周炎（GP）之间相互作用中的作用的证据。 方法：在患有T2DM（T2DM / GP，n = 11）的GP患者的牙龈组织，患有GP的全身健康患者（n = 7）以及全身和牙周健康对照（n = 11）中对MMP7表达和定位的程度进行免疫组织化学分析。建立计算机网络模型以确定MMP7和T2DM途径之间的相互作用。在小鼠MMP7敲除模型中分析MMP7对嗜中性粒细胞迁移的调节。 结果：在人牙龈组织中，与对照组相比，MMP7稳定表达的细胞在T2DM / GP患者中的比例升高（P = .014）。根据计算机模拟分析，“羟基自由基”和“过氧化氢”化合物是网络中最重要的节点之一，并且在连接“葡萄糖”和“MMP7”的最短路径内。与野生型小鼠相比，MMP7敲除小鼠的牙龈上皮中有中性粒细胞的强烈累积（P = 0.0001）。 T2DM / GP患者牙龈组织中MMP7表达升高与高血糖引起的活性氧激活有关。抑制MMP7表达导致牙龈中性粒细胞迁移受损。 原始出处： F. Zeidan‐Chulia， et al.Matrix metalloproteinase‐7 in periodontitis with type 2 diabetes mellitus. Journal of Periodontal Research. 2018 October. Doi：10.1111/jre.12583" target="_blank">Matrix metalloproteinase‐7 in periodontitis with type 2 diabetes mellitus. Journal of  Periodontal Research. 2018 October. Doi：10.1111/jre.12583

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    2019-06-18 小华子

    #基质金属蛋白酶#

    0

  2. 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    2019-03-09 柳叶一刀

    #PE#

    0

  3. 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    2019-07-14 ms7899726347904398

    #基质#

    0

  4. 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createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Oct 03 02:41:00 CST 2018, time=2018-10-03, status=1, ipAttribution=)]
    2019-04-16 ms6897892027066920

    #金属蛋白酶#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2054459, encodeId=b2a12054459cb, content=<a href='/topic/show?id=bd9b4218475' target=_blank style='color:#2F92EE;'>#基质金属蛋白酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42184, encryptionId=bd9b4218475, topicName=基质金属蛋白酶)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKCRibWHQArPHdSkqP90U1HwwqlGeU7BUgzY240D3v2ibBDJ09ybkGkwOjxz7qRmngZaGlK1taX6hfA/132, createdBy=2e772500094, createdName=小华子, createdTime=Tue Jun 18 04:41:00 CST 2019, time=2019-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727656, encodeId=af751e276562f, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, 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createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Oct 03 02:41:00 CST 2018, time=2018-10-03, status=1, ipAttribution=)]
    2019-05-12 医者仁心

    #蛋白酶#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2054459, encodeId=b2a12054459cb, content=<a href='/topic/show?id=bd9b4218475' target=_blank style='color:#2F92EE;'>#基质金属蛋白酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42184, encryptionId=bd9b4218475, topicName=基质金属蛋白酶)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKCRibWHQArPHdSkqP90U1HwwqlGeU7BUgzY240D3v2ibBDJ09ybkGkwOjxz7qRmngZaGlK1taX6hfA/132, createdBy=2e772500094, createdName=小华子, createdTime=Tue Jun 18 04:41:00 CST 2019, time=2019-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727656, encodeId=af751e276562f, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, 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authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Thu Oct 04 14:41:00 CST 2018, time=2018-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347722, encodeId=fecb34e72252, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Oct 03 07:16:03 CST 2018, time=2018-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041879, encodeId=412d10418e959, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Oct 03 02:41:00 CST 2018, time=2018-10-03, status=1, ipAttribution=)]
    2018-10-12 wxl882001

    了解一下

    0

  7. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96184, encryptionId=5a6d961841b, topicName=金属蛋白酶)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLc3PoqaNe4QTZ947pojXuchvvmkkJN0wyBBbA3LVX2WDkgiaJ7cswu9yvA4CB0NicjcrCfBY1zRPkA/132, createdBy=b3812500089, createdName=ms6897892027066920, createdTime=Tue Apr 16 13:41:00 CST 2019, time=2019-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1945191, encodeId=fd93194519129, content=<a href='/topic/show?id=249488e60fe' target=_blank style='color:#2F92EE;'>#蛋白酶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88760, encryptionId=249488e60fe, topicName=蛋白酶)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Sun May 12 18:41:00 CST 2019, time=2019-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349055, encodeId=0c053490551c, content=了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Fri Oct 12 18:07:21 CST 2018, time=2018-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1451036, encodeId=ebef1451036ce, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Thu Oct 04 14:41:00 CST 2018, time=2018-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=347722, encodeId=fecb34e72252, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Oct 03 07:16:03 CST 2018, time=2018-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041879, encodeId=412d10418e959, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Oct 03 02:41:00 CST 2018, time=2018-10-03, status=1, ipAttribution=)]
    2018-10-04 医者仁心

    #牙周#

    0

  8. 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createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Oct 03 02:41:00 CST 2018, time=2018-10-03, status=1, ipAttribution=)]
    2018-10-03 明月清辉

    谢谢分享，学习了

    0

  9. 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createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Oct 03 02:41:00 CST 2018, time=2018-10-03, status=1, ipAttribution=)]
    2018-10-03 misszhang

    谢谢MedSci提供最新的资讯

    0

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