Stroke:脑血管意外住院患者入院谨防发生急性肾损伤(AKI-D)

2015-10-22 崔倩 译 MedSci原创

目前人们对因急性缺血性脑卒中(AIS)和脑出血(ICH)住院时的需要透析的急性肾损伤(AKI-D)流行病学了解甚少,以往的研究只是从单中心或一年的时间进行了探讨。在该研究中,研究人员使用全国住院样本来评估从2002年到2011年因AIS和ICH而住院AKI-D的年发病趋势。研究人员还使用调整后的比值比(aOR)评估AKI-D对院内死亡率和不良出院事件影响的趋势,对人口和合并症指数进行了调整。研究人

目前人们对因急性缺血性脑卒中(AIS)和脑出血(ICH)住院,但需要透析的急性肾损伤(AKI-D)流行病学了解甚少,以往的研究只是从单中心或一年的时间进行了探讨。

在该研究中,研究人员使用全国住院样本来评估从2002年到2011年因AIS和ICH而住院AKI-D的年发病趋势。研究人员还使用调整后的比值比(aOR)评估AKI-D对院内死亡率和不良出院事件影响的趋势,对人口和合并症指数进行了调整。

研究人员共提取了3937928例AIS和696754例ICH患者住院的数据。AIS和ICH入院发生AKI-D的比例分别为每1000人1.5和3.5例。由AKI-D造成的复杂的发病率增加了一倍,AIS从0.9/1000增长到1.7/1000,ICH由2.1/1000增长到4.3/1000。在AIS住院时,AKI-D增加了30%的死亡率(aOR,1.18;95%的置信区间,1.12-1.48,P<0.001),同时增加了18%的不良出院事件几率(aOR, 1.18;95%的置信区间, 1.02-1.37;P<0.001)。同样的,在ICH住院时,AKI-D增加了两倍的死亡几率(aOR,1.95;95%的置信区间, 1.61–2.36; P<0.01),不良出院事件增加了74%(aOR, 1.74;95%的置信区间,1.34–2.24;P<0.01)。相关的95%置信区间,1.34-2.24; P <0.01)。AKI-D的死亡归因危险度百分比较高(98%-99%),在研究期间并没有发生显著改变。

急性肾损伤的发生使脑血管意外住院复杂化,使发病率持续增长,并与死亡率的增加和不良出院事件有关。这突出表明,在这一脆弱人群需要及早诊断急性肾损伤,并对其进行更好的风险分层,以及复杂的长期护理准备。

原始出处:

Girish N. Nadkarni,Achint A. Patel,Ioannis Konstantinidis,et al.Dialysis Requiring Acute Kidney Injury in Acute Cerebrovascular Accident Hospitalizations,Stroke,2015.10.20

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    2015-10-22 sanshengshi

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