Rheumatology: 系统性红斑狼疮疾病活动影响神经和行为认知

2021-03-27 网络网络

SLE疾病活动影响的是脑功能过程，而不是认知行为指标。红斑狼疮患者在工作记忆任务中抑制DMN区域的能力较差。这可能反映了认知任务中的情绪干扰，并可能导致认知疲劳。

许多慢性疾病中常见的因素，如疲劳和抑郁影响认知功能障碍(CD)，但系统性红斑狼疮(SLE)疾病活动对CD的影响尚不清楚。Michelle Barraclough探索SLE疾病活动对认知功能的影响，文章发表在Rheumatology杂志。

该研究选择两组系统性红斑狼疮患者：稳定期/低活动期(SLE-S，n = 36例)和活动期(SLE-F，n = 26例)。SLE-F组在疾病爆发期间进行研究；当疾病活动减少时进行第二次检查。除了人口学、临床和精神病学数据外，还使用计算机化的一组测试(CANTAB®)测量CD。功能磁共振成像(fMRI)用于检测神经元对工作记忆和情绪处理任务的反应。

SLE-S和SLE-Fv1组间n-back任务时BOLD信号差异分析

SLE-F组两次BILAG评分的变化

使用CANTAB®测试时，两组之间没有发现差异。功能磁共振成像结果显示，在工作记忆任务中，与SLE-S组相比，SLE-F组在内侧前额叶皮质的反应衰减程度较低(p = 0.012)。SLE-F组内的探索性相关性显示神经元反应与抑郁、认知疲劳、疾病活动性测量和IL-6相关。

许多因素影响SLE的认知功能。SLE的疾病活动和炎症在影响关键的认知过程中很重要。疾病活动影响的是脑功能过程，而不是认知行为指标。红斑狼疮患者在工作记忆任务中抑制DMN区域的能力较差。这可能反映了认知任务中的情绪干扰，并可能导致认知疲劳。许多因素与红肿患者的脑功能有关，这对整体治疗具有潜在的意义。在这种复杂的情况下，当解决SLE的认知功能障碍时，需要对患者进行整体评估。

原文出处

Barraclough, Michelle et al. “The effects of disease activity on neuronal and behavioural cognitive processes in systemic lupus erythematosus.” Rheumatology (Oxford, England), keab256. 24 Mar. 2021, doi:10.1093/rheumatology/keab256

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2022-02-08 qingrejiedu

#系统性#

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2021-11-27 146e31c1m79暂无昵称

学习了

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2021-09-13 xue8614

#疾病活动#

43 0
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2021-11-16 风铃821

#Rheumatology#

30 0
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2021-07-01 王子燕窝

深度好文，受益匪浅

61 0
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2021-04-16 豆腐有点酸

学习了，不错的方向

68 0
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encryptionId=8a3a6814425, topicName=狼疮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a6e2500005, createdName=sunrural_42825357, createdTime=Mon Mar 29 04:48:46 CST 2021, time=2021-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1436277, encodeId=ddf014362e764, content=<a href='/topic/show?id=22f8e71238d' target=_blank style='color:#2F92EE;'>#红斑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77123, encryptionId=22f8e71238d, topicName=红斑)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Mar 29 04:48:46 CST 2021, time=2021-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951893, encodeId=2db8951893fd, content=认真学习了, 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2021-04-08 gqylhd

许多因素与红肿患者的脑功能有关，红肿患者，写错了吧

73 0
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encryptionId=8a3a6814425, topicName=狼疮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a6e2500005, createdName=sunrural_42825357, createdTime=Mon Mar 29 04:48:46 CST 2021, time=2021-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1436277, encodeId=ddf014362e764, content=<a href='/topic/show?id=22f8e71238d' target=_blank style='color:#2F92EE;'>#红斑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77123, encryptionId=22f8e71238d, topicName=红斑)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Mar 29 04:48:46 CST 2021, time=2021-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951893, encodeId=2db8951893fd, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sun Mar 28 17:30:02 CST 2021, time=2021-03-28, status=1, ipAttribution=)]
2021-03-29 sunrural_42825357

#狼疮#

43 0
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createdBy=3307462, createdName=风铃821, createdTime=Tue Nov 16 00:48:46 CST 2021, time=2021-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=978723, encodeId=a55b9e8723ec, content=深度好文，受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210701/744f639c0ac24549ab1e0c4fbb6876ed/9afc870f9e0d45a0963b7dae6cc8c8b2.jpg, createdBy=11b55161224, createdName=王子燕窝, createdTime=Thu Jul 01 20:21:13 CST 2021, time=2021-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=957711, encodeId=edab95e7115a, content=学习了，不错的方向, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210311/2a8273a0f8d34d10baae98ab03ee8bdc/083e1bc82d3a438891b1052e1192a529.jpg, createdBy=fd361960002, createdName=豆腐有点酸, createdTime=Fri Apr 16 21:44:11 CST 2021, time=2021-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=955341, encodeId=fcfd955341b0, content=许多因素与红肿患者的脑功能有关，红肿患者，写错了吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3c31528806, createdName=gqylhd, createdTime=Thu Apr 08 23:25:59 CST 2021, time=2021-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1387435, encodeId=5a60138e4355f, content=<a href='/topic/show?id=8a3a6814425' target=_blank style='color:#2F92EE;'>#狼疮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68144, encryptionId=8a3a6814425, topicName=狼疮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a6e2500005, createdName=sunrural_42825357, createdTime=Mon Mar 29 04:48:46 CST 2021, time=2021-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1436277, encodeId=ddf014362e764, content=<a href='/topic/show?id=22f8e71238d' target=_blank style='color:#2F92EE;'>#红斑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77123, encryptionId=22f8e71238d, topicName=红斑)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Mar 29 04:48:46 CST 2021, time=2021-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951893, encodeId=2db8951893fd, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sun Mar 28 17:30:02 CST 2021, time=2021-03-28, status=1, ipAttribution=)]
2021-03-29 zhouqu_8

#红斑#

40 0
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createdBy=3307462, createdName=风铃821, createdTime=Tue Nov 16 00:48:46 CST 2021, time=2021-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=978723, encodeId=a55b9e8723ec, content=深度好文，受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210701/744f639c0ac24549ab1e0c4fbb6876ed/9afc870f9e0d45a0963b7dae6cc8c8b2.jpg, createdBy=11b55161224, createdName=王子燕窝, createdTime=Thu Jul 01 20:21:13 CST 2021, time=2021-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=957711, encodeId=edab95e7115a, content=学习了，不错的方向, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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encryptionId=8a3a6814425, topicName=狼疮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a6e2500005, createdName=sunrural_42825357, createdTime=Mon Mar 29 04:48:46 CST 2021, time=2021-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1436277, encodeId=ddf014362e764, content=<a href='/topic/show?id=22f8e71238d' target=_blank style='color:#2F92EE;'>#红斑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77123, encryptionId=22f8e71238d, topicName=红斑)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Mar 29 04:48:46 CST 2021, time=2021-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=951893, encodeId=2db8951893fd, content=认真学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6EF3hKja8nER8RMzxQdria9eCYFhgLTLsDOeqnvIYdeLDz5eP6EnicLuE5gibiawgno4zUA0jAR7Nbtp2llQ9fs3Mk/0, createdBy=278f1986883, createdName=医鸣惊人, createdTime=Sun Mar 28 17:30:02 CST 2021, time=2021-03-28, status=1, ipAttribution=)]
2021-03-28 医鸣惊人

认真学习了

81 0

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