Nat Commun:无瑕美肌如何造?祛疤新思路,带你击退美丽的“天敌”

2021-05-14 生物探索 生物探索

疤痕是创伤愈合过程的自然产物,一旦形成,就难以清除,如果不幸留在脸部,就更令人扎心了。因此,爱美人士绞尽脑汁也要寻找出对付这些疤痕的解药。

疤痕是创伤愈合过程的自然产物,一旦形成,就难以清除,如果不幸留在脸部,就更令人扎心了。因此,爱美人士绞尽脑汁也要寻找出对付这些疤痕的解药。 近日,《Nature Communications》杂志发表了一篇题为Sox9 and Rbpj differentially regulate endothelial to mesenchymal transition and wound scarring in murine endovascular progenitors的文章,研究发现了一种通过阻断皮肤愈合过程来去除疤痕的新方法。 众所周知,当皮肤表面破损后,皮肤内的毛细血管会分泌大量的成纤维细胞,这些细胞会产生胶原蛋白,形成疤痕组织中的坚硬物质。 不仅如此,由于内皮的强大再生能力归因于控制内皮层的血管内祖细胞(EVP),而内皮中Sox9基因的缺失会严重损害内皮细胞向间质转化(EndMT),从而缓解伤口愈合过程中的疤痕形成。因此,研究人员猜测是否能通过靶向参与疤痕形成的特定基因SOX9,以关闭疤痕形成过程的分子机制。 血管内祖细胞命运的调控 为了验证猜想,研究人员评估了SOX9在EVP表达中

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    2021-05-28 liuli5079
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    2021-06-08 晓辰
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    2021-12-29 liye789132251