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Hypertension：治疗青少年高血压的一线抗高血压药物

2018-08-06 MedSci MedSci原创

青少年高血压血管紧张素转换酶抑制剂血管紧张素受体阻滞剂
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青少年高血压首先推荐改变生活方式，若无效则予以药物治疗，但目前尚无推荐的一线抗高血压药物。Jacopo Burrello等人进行一Meta分析，对比现有的关于药物治疗青少年高血压的随机临床试验结果。研究人员共筛选了554个相关研究，最终纳入13个随机对照试验（均至于包含50个患者、随访达4周）。治疗后收缩压（SBP）和舒张压（DBP）降低为并列的主要结点。共纳入2378位青少年患者，中位年龄12岁

青少年高血压首先推荐改变生活方式，若无效则予以药物治疗，但目前尚无推荐的一线抗高血压药物。Jacopo Burrello等人进行一Meta分析，对比现有的关于药物治疗青少年高血压的随机临床试验结果。

研究人员共筛选了554个相关研究，最终纳入13个随机对照试验（均至于包含50个患者、随访达4周）。治疗后收缩压（SBP）和舒张压（DBP）降低为并列的主要结点。

共纳入2378位青少年患者，中位年龄12岁，中位随访35天。赖诺普利和依那普利降低SBP和DBP的效果优于安慰剂；若只看DBP的话，氯沙坦的降压效果优于安慰剂，赖诺普利和依那普利的降压效果优于依普利酮。血管紧张素转换酶抑制剂和血管紧张素受体阻滞剂可明显降低SBP和DBP，盐皮质激素受体拮抗剂降DBP的效果次于血管紧张素转换酶抑制剂。经研究水平平均年龄、男女比、平均起始血压和平均体重进行校正后，仅血管紧张素转换酶抑制剂可显著降低DBP。

根据当前的分析，血管紧张素转换酶抑制剂和血管紧张素受体阻滞剂是治疗青少年高血压的最佳选择。但是，由于其他种类的抗高血压药物的可用数据匮乏，因此，尚不能得到明确的结论，有必要继续深入进行研究。

原始出处：

Jacopo Burrello，et al. Pharmacological Treatment of Arterial Hypertension in Children and Adolescents. Hypertension. 2018；72：306-313

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    2019-07-20 zexyw01

    #抗高血压药#

    0

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    2018-12-11 12498ebem19暂无昵称

    #TENS#

    0

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    2018-11-09 klivis

    #抗高血压#

    0

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    2019-05-17 小刀医生

    #青少年高血压#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2027116, encodeId=ed24202e11672, content=<a href='/topic/show?id=5dd1558503e' target=_blank style='color:#2F92EE;'>#抗高血压药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55850, encryptionId=5dd1558503e, topicName=抗高血压药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=362b271, createdName=zexyw01, createdTime=Sat Jul 20 13:45:00 CST 2019, time=2019-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2038958, encodeId=375a203895831, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Tue Dec 11 09:45:00 CST 2018, time=2018-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2039788, encodeId=c1762039e8809, content=<a href='/topic/show?id=bf0f5584ef6' target=_blank style='color:#2F92EE;'>#抗高血压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55847, encryptionId=bf0f5584ef6, topicName=抗高血压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87531, createdName=klivis, createdTime=Fri Nov 09 05:45:00 CST 2018, time=2018-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1705779, encodeId=50501e05779de, content=<a href='/topic/show?id=8be7989825f' target=_blank style='color:#2F92EE;'>#青少年高血压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98982, encryptionId=8be7989825f, topicName=青少年高血压)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ec8531078117, createdName=小刀医生, createdTime=Fri May 17 22:45:00 CST 2019, time=2019-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727513, encodeId=8ff21e275134c, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Dec 12 14:45:00 CST 2018, time=2018-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501317, encodeId=1895150131ee0, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Wed Aug 08 07:45:00 CST 2018, time=2018-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1545684, encodeId=d104154568458, content=<a href='/topic/show?id=a383558515b' target=_blank style='color:#2F92EE;'>#抗高血压药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55851, encryptionId=a383558515b, topicName=抗高血压药物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e46713811513, createdName=ms9474365431325850, createdTime=Wed Aug 08 07:45:00 CST 2018, time=2018-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336875, encodeId=72903368e52e, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Mon Aug 06 19:10:55 CST 2018, time=2018-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336862, encodeId=61e03368625d, content=了解一下，谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Mon Aug 06 18:11:18 CST 2018, time=2018-08-06, status=1, ipAttribution=)]
    2018-12-12 feather89

    #PE#

    0

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    2018-08-08 jambiya

    #Hypertension#

    0

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    2018-08-08 ms9474365431325850

    #抗高血压药物#

    0

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    2018-08-06 sunfeifeiyang

    阅

    0

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    2018-08-06 天地飞扬

    了解一下，谢谢分享！

    0

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