JACC:抗凝治疗的房颤患者的左心房血栓发生率

2021-06-20 Nebula MedSci原创

接受抗凝治疗的房颤/房扑患者在在转复或导管消融前可进行常规术前经食管超声心动图检查

左房(LA)血栓是房颤(AF)或心房扑动(AFL)患者进行转复和导管消融的禁忌症,因转复和消融会使血栓脱落而导致心源性卒中。然而,抗凝治疗指南中,AF或AFL患者左房血栓的发生率尚不清楚,提示在进行转复或导管消融前需要进行经食管超声心动图(TEE)检查。

本研究旨在量化指南指导的抗凝治疗的AF/AFL患者的LA血栓患病率,并确定高危亚组。

研究人员系统地检索了EMBASE、MEDLINE和CENTRAL数据库从伊始到2020年7月的研究,筛选关于服用维生素K拮抗剂(VKA)或直接口服抗凝剂(DOAC)3周后进行了TEE的AF/AFL患者LA血栓发生率的研究。采用随机效应模型进行Meta分析。

各种分组患者的LA血栓发生率

共筛选到了35项研究,共14653位患者。LA血栓中位加权发生率是2.73%(95%CI 1.95%-3.80%)。采用VKA和DOAC治疗的患者的LA血栓发生率相近(2.8% vs 3.12%;p=0.674)。非阵发性AF/AFL患者的LA血栓发生率是阵发性房颤患者的4倍(4.81% vs 1.03;p<0.001)。接受转复治疗的患者与接受消融治疗的患者相比,LA血栓的发生率更高(5.55% vs 1.65%;p<0.001)。CHA2DS2-VASc评分≥3分的患者LA血栓的发生率高于评分≤2分的患者(6.31% vs 1.06%;p<0.001)。

综上所述,接受抗凝治疗的AF/AFL患者LA血栓发生率较高,这些患者在转复或导管消融前可进行常规术前TEE检查,以排查LA血栓,防止发生心源性卒中

原始出处:

Lurie Antony,Wang Jia,Hinnegan Kyra J et al. Prevalence of Left Atrial Thrombus in Anticoagulated Patients With Atrial Fibrillation.[J] .J Am Coll Cardiol, 2021, 77: 2875-2886. https://doi.org/10.1016/j.jacc.2021.04.036

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    2022-01-28 ylz8411
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    2022-02-24 hbwxf
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href='/topic/show?id=986a5101e46' target=_blank style='color:#2F92EE;'>#心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51017, encryptionId=986a5101e46, topicName=心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20ba21064884, createdName=sodoo, createdTime=Tue Jun 22 13:41:59 CST 2021, time=2021-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=975365, encodeId=79759e53657f, content=学习了<a href='/topic/show?id=974e51e2810' target=_blank style='color:#2F92EE;'>#心血管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51728, encryptionId=974e51e2810, topicName=心血管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4bb81518090, createdName=dahonghuayang, createdTime=Mon Jun 21 10:31:44 CST 2021, time=2021-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=975295, encodeId=fb8e9e5295fc, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05432203583, createdName=120bdad3m03(暂无昵称), createdTime=Mon Jun 21 01:42:05 CST 2021, time=2021-06-21, status=1, ipAttribution=)]
    2021-06-24 澜儿

    学习了

    0

  5. 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href='/topic/show?id=986a5101e46' target=_blank style='color:#2F92EE;'>#心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51017, encryptionId=986a5101e46, topicName=心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20ba21064884, createdName=sodoo, createdTime=Tue Jun 22 13:41:59 CST 2021, time=2021-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=975365, encodeId=79759e53657f, content=学习了<a href='/topic/show?id=974e51e2810' target=_blank style='color:#2F92EE;'>#心血管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51728, encryptionId=974e51e2810, topicName=心血管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4bb81518090, createdName=dahonghuayang, createdTime=Mon Jun 21 10:31:44 CST 2021, time=2021-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=975295, encodeId=fb8e9e5295fc, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05432203583, createdName=120bdad3m03(暂无昵称), createdTime=Mon Jun 21 01:42:05 CST 2021, time=2021-06-21, status=1, ipAttribution=)]
    2021-06-24 艾雯

    学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1659725, encodeId=381f1659e25fe, content=<a href='/topic/show?id=da5c480e024' target=_blank style='color:#2F92EE;'>#左心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48070, encryptionId=da5c480e024, topicName=左心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=50dc25016902, createdName=ylz8411, createdTime=Fri Jan 28 14:41:59 CST 2022, time=2022-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1826701, encodeId=1cae1826e0151, content=<a href='/topic/show?id=e5283e89970' target=_blank style='color:#2F92EE;'>#发生率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37899, encryptionId=e5283e89970, topicName=发生率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, 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href='/topic/show?id=986a5101e46' target=_blank style='color:#2F92EE;'>#心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51017, encryptionId=986a5101e46, topicName=心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20ba21064884, createdName=sodoo, createdTime=Tue Jun 22 13:41:59 CST 2021, time=2021-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=975365, encodeId=79759e53657f, content=学习了<a href='/topic/show?id=974e51e2810' target=_blank style='color:#2F92EE;'>#心血管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51728, encryptionId=974e51e2810, topicName=心血管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4bb81518090, createdName=dahonghuayang, createdTime=Mon Jun 21 10:31:44 CST 2021, time=2021-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=975295, encodeId=fb8e9e5295fc, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05432203583, createdName=120bdad3m03(暂无昵称), createdTime=Mon Jun 21 01:42:05 CST 2021, time=2021-06-21, status=1, ipAttribution=)]
  7. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=975295, encodeId=fb8e9e5295fc, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05432203583, createdName=120bdad3m03(暂无昵称), createdTime=Mon Jun 21 01:42:05 CST 2021, time=2021-06-21, status=1, ipAttribution=)]
  8. 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href='/topic/show?id=986a5101e46' target=_blank style='color:#2F92EE;'>#心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51017, encryptionId=986a5101e46, topicName=心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20ba21064884, createdName=sodoo, createdTime=Tue Jun 22 13:41:59 CST 2021, time=2021-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=975365, encodeId=79759e53657f, content=学习了<a href='/topic/show?id=974e51e2810' target=_blank style='color:#2F92EE;'>#心血管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51728, encryptionId=974e51e2810, topicName=心血管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4bb81518090, createdName=dahonghuayang, createdTime=Mon Jun 21 10:31:44 CST 2021, time=2021-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=975295, encodeId=fb8e9e5295fc, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05432203583, createdName=120bdad3m03(暂无昵称), createdTime=Mon Jun 21 01:42:05 CST 2021, time=2021-06-21, status=1, ipAttribution=)]
    2021-06-22 sodoo
  9. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=975295, encodeId=fb8e9e5295fc, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05432203583, createdName=120bdad3m03(暂无昵称), createdTime=Mon Jun 21 01:42:05 CST 2021, time=2021-06-21, status=1, ipAttribution=)]
    2021-06-21 dahonghuayang

    学习了#心血管#

    0

  10. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=975295, encodeId=fb8e9e5295fc, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05432203583, createdName=120bdad3m03(暂无昵称), createdTime=Mon Jun 21 01:42:05 CST 2021, time=2021-06-21, status=1, ipAttribution=)]
    2021-06-21 120bdad3m03(暂无昵称)

    学习了

    0

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房颤以及接受心脏机械瓣膜植入的患者需接受持续的抗凝治疗,主要是维生素k拮抗剂,但由于侵入性手术,患者需中断华法林治疗。抗凝桥接治疗的目的是尽可能减少房颤患者脱离规律抗凝治疗的时间。

JAMA:植入式循环监护大大提高了大血管或小血管疾病中风患者的房颤检出率

对于大血管或小血管疾病导致的中风患者,其12个月的房颤发生率高于先前的认识,植入式循环监护大大提高了房颤检出率,未来需要进一步的研究以识别额外的房颤事件是否具有临床意义。

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Eur Heart J:房颤患者戒酒后卒中风险降低

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