Hypertension:多囊卵巢综合症、肥胖症以及体重增加与妊娠高血压疾病之间的关联

2021-02-17 MedSci原创 MedSci原创

肥胖,特别是腹部肥胖,以及从青春期到46岁期间的体重增加,而非srPCOS或高雄激素血症,与HDP的风险增加有关。

近日,血管权威杂志Hypertension上发表了一篇研究文章,这项基于人群的前瞻性队列研究旨在评估多囊卵巢综合征(PCOS)、肥胖、体重增加和高雄激素血症在PCOS和非PCOS女性育龄期妊娠高血压病(HDP)发展中的作用。

研究人群为患有HDP (n=408)或未患HDP (n=3373)的女性,她们从14岁至46岁接受了长期随访。通过结合医院出院记录、芬兰医疗出生登记数据和46岁时的问卷数据,确认了参与者HDP的诊断情况。有自我报告的多囊卵巢综合征女性(srPCOS;n=279),定义为31岁时少闭经和多毛,或46岁时诊断为PCOS,并与未报告PCOS的女性(n=1577)进行比较。

srPCOS妇女患HDP的风险增加(比值比为1.56 [95%CI为1.03-2.37]),但调整体重指数后,相关性消失。在伴有HDP的srPCOS女性从14岁到46岁体重指数的增加程度显著高于没有HDP的srPCOS女性(中位数[四分位数范围]为9.82[6.23-14.6]和7.21 [4.16-10.5]kg/m2;P<0.001)。在非PCOS的女性中,伴有HDP的女性(7.54 [5.32-11.62]kg/m2;P<0.001)体重指数的增加程度显著高于无HDP女性(6.33 [3.90-9.33]kg/m2;P<0.001)。31~46岁腰围增加与HDP相关,与PCOS无关。31~46岁时高雄激素血症与HDP无关(1.44[0.98-2.11])。

总之,肥胖,特别是腹部肥胖,以及从青春期到46岁期间的体重增加,而非srPCOS或高雄激素血症,与HDP的风险增加有关

原始出处:

Juhani S.S. Rantakallio.et al.Association of Self-Reported Polycystic Ovary Syndrome, Obesity, and Weight Gain From Adolescence to Adulthood With Hypertensive Disorders of Pregnancy A Community-Based Approach.Hypertension.2021.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.120.15702

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    2021-08-21 feather89
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GetPortalCommentsPageByObjectIdResponse(id=925217, encodeId=b85592521ef5, content=所以,在孕期,控制体重很关键。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Thu Feb 18 10:07:27 CST 2021, time=2021-02-18, status=1, ipAttribution=)]
    2021-03-28 ms2000001361349190

    控制体重

    0

  5. 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  6. 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  7. 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GetPortalCommentsPageByObjectIdResponse(id=925217, encodeId=b85592521ef5, content=所以,在孕期,控制体重很关键。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Thu Feb 18 10:07:27 CST 2021, time=2021-02-18, status=1, ipAttribution=)]
    2021-02-18 Jessica

    所以,在孕期,控制体重很关键。

    0

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