Clin Gastroenterology H:成年后的肥胖和体重增加与微观结肠炎的风险较低相关

2019-11-18 不详 MedSci原创

肥胖会促进肠道炎症,并可能导致炎症性肠病的发病。在本项前瞻性队列研究中,研究人员探究了肥胖与微观结肠炎风险之间的关联。

背景与目标
肥胖会促进肠道炎症,并可能导致炎症性肠病的发病。在本项前瞻性队列研究中,研究人员探究了肥胖与微观结肠炎风险之间的关联。

方法
研究人员收集了192101名参加“护士健康研究”(NHS)(从1986年至2014年)或NHSII(1991年至2015年)的女性的数据。研究人员使用体重指数(BMI)定义肥胖。通过查阅病历证实为显微镜下的结肠炎。最后使用Cox比例风险模型估算调整后的风险比(aHRs)和95%CI。

结果
在NHS和NHSII的参与者中,在4223868人年的随访评估中确认了244例微观结肠炎。较高的BMI与患微观结肠炎的风险呈负相关(P<.001)。与BMI在18.5至20.9 kg/m2范围内的女性相比,超重女性(BMI在25-29.9 kg/m2)的aHRs为0.61(95%CI,0.41-0.91 )和肥胖女性(BMI≥30 kg/m2)的aHRs为0.50(95%CI,0.32–0.79)。体重指数每增加5 kg/m2,aHR为0.79(95%CI,0.69–0.90)。成年初期(18岁)以来体重增加也与显微镜下结肠炎的风险呈负相关(P= 0.001)。自成年后每增加10公斤体重的aHR为0.85(95%CI,0.77-0.94)。

结论
本项研究指出成年早期以来的肥胖和体重增加与微观结肠炎的风险较低相关。

原始出处:

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    2020-10-10 许安
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