Nat Med:1000多对双胞胎研究告诉你,人类餐后是怎么对食物进行反应的?

2020-06-14 MedSci原创 MedSci原创

研究人员在英国招募了1,002对双胞胎和没有血缘关系的健康成年人参与PREDICT 1研究,并评估了临床环境和家庭中的餐后代谢反应。

对食物的代谢反应会影响心脏代谢疾病的风险,但至今为止,缺乏大规模的高分辨率研究。

最近,研究人员在英国招募了1,002对双胞胎和没有血缘关系的健康成年人参与PREDICT 1研究,并评估了临床环境和家庭中的餐后代谢反应。

研究人员观察到摄入相同的食物后,血甘油三酯(103%)、葡萄糖(68%)和胰岛素(59%)的餐后反应存在较大的个体间差异性(以群体变异系数(s.d./平均值,%)衡量)。人的特异性因素,如肠道微生物组,对餐后血脂的影响(7.1%的方差)大于餐中宏量营养素(3.6%),但对餐后血糖的影响不大(分别为6.0%和15.4%)。遗传变异对预测的影响不大(葡萄糖9.5%,甘油三酯0.8%,C肽0.2%)。

研究结果在一个美国队列(n = 100人)中得到了独立验证。

此外,研究人员开发了一个机器学习模型,可以预测食物摄入后,人体甘油三酯(r = 0.47)和血糖(r = 0.77)的反应。

这些发现可能对制定个性化的饮食策略有参考价值。

 

原始出处:

Sarah E. Berry et al. Human postprandial responses to food and potential for precision nutrition, Nature Medicine (2020). 

 

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    2020-12-09 liye789132251
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    2020-06-16 yhy100201
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