Diabetes Care:空腹血糖水平对心血管疾病的长期**风险

2019-01-09 xing.T MedSci原创

由此可见,中年糖尿病患者具有较高的长期CVD绝对风险。这些数据支持中年人进行血糖监测对于CVD预防的重要性。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,该研究旨在根据低于糖尿病阈值的空腹血糖(FG)水平来估计血管疾病(CVD)的长期绝对风险。

研究人员汇总了1960年到2015年期间来自美国黑人和女性的七个观察队列的数据。研究人员将FG分类如下:<5.0、5.0-5.5、5.6-6.2、6.3-6.9mmol/L,以及糖尿病(FG≥7.0mmol/L或使用糖尿病药物)。CVD被定义为致命/非致死性冠心病和致命/非致命性卒中。研究人员使用改良的Kaplan-Meier生存分析估计了年龄为55岁时根据FG分类的CVD风险,并调整了非CVD死亡的竞争风险。研究人员还根据50岁前FG的变化评估了发生CVD的风险,特别是<5.6 mmol/L,5.6-6.9 mmol/L和糖尿病的个体。

该研究的样本包括了19630名参与者(6197名黑人和11015名女性),既往没有CVD事件。85岁以下个体患CVD的风险从女性的15.3%(<5.0mmol/L)增加到38.6%(糖尿病水平),男性从21.5%(5.0-5.5 mmol/L)增加到47.7%(糖尿病水平)。与FG最低的男性相比,FG为6.3-6.9mmol/L与较高的长期CVD风险相关,但在女性中无关。中年期间血糖升高转化为糖尿病与较高的血管风险相关(1.3-3.6倍),相比于低于糖尿病阈值的血糖水平个体。

由此可见,中年糖尿病患者具有较高的长期CVD绝对风险。这些数据支持中年人进行血糖监测对于CVD预防的重要性。

原始出处:

Michael P. Bancks,et al. Long-Term Absolute Risk for Cardiovascular Disease Stratified by Fasting Glucose Level.Diabetes Care.2018.https://doi.org/10.2337/dc18-1773

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    2022-06-24 ms6000001792792657

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    0

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由此可见,空腹血糖升高是高血压发病的独立危险因素。需要进一步的研究来确定降糖治疗是否可以预防高血压的发生。

JAHA:长期正常空腹血糖与冠心病风险之间的关系!

由此可见,不同的长期正常FPG轨迹与冠心病的发生有关,这是独立于其他代谢因素,包括FPG水平。这些研究结果对那些血糖正常的个体进行冠心病干预和预防具有提示意义。