CLIN CANCER RES：CD271通过上调Slug促进头颈部鳞状细胞癌侵袭和转移

2018-02-26 MedSci MedSci原创

头颈部鳞状细胞癌（HNSCC）由不同亚群细胞组成，异质性较大。CD271与肿瘤源发细胞亚群有关。CLIN CANCER RES近期发表了一篇文章，研究CD271在调节HNSCC转移性特征方面的作用

头颈部鳞状细胞癌（HNSCC）由不同亚群细胞组成，异质性较大。CD271与肿瘤源发细胞亚群有关。CLIN CANCER RES近期发表了一篇文章，研究CD271在调节HNSCC转移性特征方面的作用。

作者过表达鼠和人口腔鳞状细胞癌细胞CD271水平，在体外和体内模型中研究CD271活化对这些细胞侵袭和转移亚型的影响。使用人神经生长因子（NGF）活化CD271，使用shRNA敲低CD271上调的Snai2表达，评估CD271诱导侵袭性亚型机制。在异种移植模型及人原发口腔癌中评估CD271表达，并与临床特征和预后数据相联系。研究结果表明，过表达CD271会产生侵袭性和转移性更强的亚型。Slug（一种上皮间质化（EMT）相关转录因子，由Snai2编码）在MOC2-CD271和HSC3-CD271细胞中表达水平高于亲代细胞。使用NGF活化CD271可以增强CD271过表达细胞的侵袭性，Snai2敲低则可以抑制这一现象。在异种移植模型和人HNSCC中，CD271表达与Snai2表达、高淋巴结转移和无病生存时间减少有关。

文章最后认为，CD271活化导致Snai2/Slug上调，产生侵袭性更强的肿瘤细胞亚型，增强其向区域淋巴结转移的能力。这些研究结果表明CD271是治疗口腔癌转移的理想治疗靶点。

原始出处：

Man Ki Chung,Young Ho Jung,et al.CD271 Conters an Invasive and Metastatic Phenotype of Head and Neck Squamous Cell Carcinoma through the Upregulation of Slug.CLIN CANCER RES.February 2018 doi:10.1158/1078-0432.CCR-17-0866

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2018-09-19 qingting

#细胞癌#

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2018-10-16 小小小向日葵

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2018-02-28 Smile2680

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2018-02-28 wshxjq

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2018-02-28 木头人519

#颈部#

23 0
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2018-02-26 13718711b3m

学习了.获益匪浅.感谢分享

54 0

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