J Rheumatol:运动超声心动图预测硬皮病高危人群的肺动脉高压

2019-11-21 xiangting MedSci原创

在SSc高危人群中,EE阳性可以预测未来出现静息PH。

这项研究旨在评估运动超声心动图(EE)阳性是否能预测系统性硬化症(SSc)高危人群未来出现PAH

这是一个前瞻性观察队列,纳入具有与PAH风险升高相关特征的SSc患者。所有患者均接受临床评估和运动超声心动图(EE)。EE阳性定义为运动后右心室收缩压(RVSP)升高≥20mmHgEE阳性的所有患者均接受了右心导管(RHC)。

共招募了85名患者。在EE阳性队列平均4年的随访期间,43名患者中有10名(23%)在RHC上出现了静息性肺动脉高压(PH)(PAH 4名,肺静脉高压(​​PVH5名,间质性肺病相关PH 1名)。在持续阴性EE队列中,42名患者中只有3名(7%)出现静息PH1PAH2 PVH)(p=0.04)。EE阳性组的其余33名未出现静息PH患者中,有22名(67%)在平均5年的随访期内出现持续EE阳性。

SSc高危人群中,EE阳性可以预测未来出现静息PH。此外,大多数患者可以持续EE阳性,而没有发展为静息PH。最后,EE持续阴性可以识别未来的PH低危患者。

原始出处:

Kaitlin A. Quinn. Exercise Echocardiography Predicts Future Development of Pulmonary Hypertension in a High-Risk Cohort of Scleroderma Patients. J Rheumatol. 15 November 2019.

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    2019-11-23 rgjl
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    2019-11-21 明天jing

    肺动脉高压表面是罕见病,事实上临床上并不少见,治疗药物虽然有一些,但是整体仍然不理解,可能未来需要采用综合治疗措施。

    0

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