Diabetes Care:肥胖和糖尿病患者减肥手术与癌症发病率之间的关联

2021-11-24 MedSci原创 MedSci原创

这些结果表明减肥手术可以预防肥胖和糖尿病患者的癌症发生,并且糖尿病的持久缓解与癌症风险降低相关。

据估计,2012年全世界所有癌症病例中有6%可归因于糖尿病和超重/肥胖的综合效应。此外,糖尿病和超重/肥胖的结合导致肝癌、食管腺癌和子宫内膜癌病例增加25-40%。 因此,肥胖和糖尿病日益增加的全球趋势导致癌症患病率增加。肥胖与13种特定癌症类型之间的因果关系已得到充分证实。虽然减肥手术已被证明可以降低肥胖患者的癌症风险,但减肥手术对肥胖和糖尿病患者癌症风险的影响研究较少。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员在匹配的前瞻性瑞典肥胖受试者(SOS)研究中评估了肥胖和糖尿病患者在减肥手术和常规治疗后的长期癌症发病率。

SOS研究评估了减肥手术或常规治疗后的患者长期结局。目前的分析包括701名基线患有肥胖症和2型糖尿病的患者,其中393名接受了减肥手术,308名接受了常规减肥治疗。关于癌症事件的信息是从瑞典国家癌症登记处获得的。中位随访时间为21.3年(四分位距为17.6-24.8年,最长达30.7年)。

在随访期间,接受减肥手术治疗的肥胖和糖尿病患者的首次癌症发病率为9.1人/1000人每年(95%CI为7.2-11.5),14.1人/1000人每年(95%CI为11.2-17.7),在接受常规减肥治疗的患者中(调整后的风险比为0.63[95%CI为0.44-0.89],P=0.008)。此外,手术与女性癌症发病率降低相关(0.58[0.38-0.90],P=0.016),尽管性别-治疗相互作用不显著(P=0.630)。此外,10年随访时糖尿病缓解与癌症发病率降低相关(0.40[0.22-0.74],P=0.003)。

由此可见,这些结果表明减肥手术可以预防肥胖和糖尿病患者的癌症发生,并且糖尿病的持久缓解与癌症风险降低相关。

原始出处:
 
Kajsa Sjöholm,et al.Association of Bariatric Surgery With Cancer Incidence in Patients With Obesity and Diabetes: Long-Term Results From the Swedish Obese Subjects Study.Diabetes care.2021.https://care.diabetesjournals.org/content/early/2021/11/19/dc21-1335

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    2021-11-25 ms1000000121117280

    学习

    0

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    2021-11-24 CHANGE

    什么时候有懒人用的减肥神药?

    0

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