Autophagy: 复旦研究人员发现,雷帕霉素可以防止自然流产

2020-10-10 haibei MedSci原创

临床上公认,自然流产与10-15%的人类妊娠有关。虽然有研究报道,各种因素(如染色体和子宫结构异常、内分泌异常、子宫内膜感染和免疫因素等)参与了自然流产的病因,但其根本机制仍不清楚。

临床上公认,自然流产与10-15%的人类妊娠有关。虽然有研究报道,各种因素(如染色体和子宫结构异常、内分泌异常、子宫内膜感染免疫因素等)参与了自然流产的病因,但其根本机制仍不清楚,很大一部分自然流产的病例至今仍无法解释。

子宫内膜蜕膜化缺陷被广泛认为是自然流产的重要原因。普遍的子宫内膜蜕膜化也包括NK细胞的大量浸润和富集。然而,至今为止,脱膜NK(dNK)细胞驻留的基本机制在很大程度上仍然是未知的。

最近,研究人员在Autophagy杂志发文,其观察到,在脱膜过程中,脱膜基质细胞(DSCs)的大自噬/自噬增加,促进了正常妊娠期间dNK细胞的粘附和保留。从机制上讲,这一过程是通过激活MITF-TNFRSF14/HVEM信号,并以MMP9依赖性的方式进一步上调多种粘附附着物(如Selectins和ICAMs)来介导的。

原因不明的自然流产患者中呈现出了DSC自噬和dNK细胞驻留不足。此外,研究人员在NK细胞耗竭的小鼠中观察到胎盘血管重塑不良、植入数量低和胚胎损失比例高等现象。

在治疗研究中,低剂量雷帕霉素是一种已知的自噬诱导剂,可显著促进子宫内膜自噬和NK细胞驻留,并改善自然流产小鼠模型的胚胎吸收,这应依赖于MITF-TNFRSF14/HVEM-MMP9-诱导分子轴的激活。

这一观察揭示了DSCs自噬驱动dNK细胞驻留的新的分子机制,为预防自然流产提供了潜在的治疗策略。

 

原始出处:

Han Lu et al. Rapamycin prevents spontaneous abortion by triggering decidual stromal cell autophagy-mediated NK cell residence. Autophagy (2020). DOI: https://doi.org/10.1080/15548627.2020.1833515

 

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    2021-04-28 ms2000000630457342

    收益

    0

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    2020-10-16 ms9000001186008086

    认真学习

    0

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    2020-10-14 lovetcm

    #雷帕霉素#可以防止#自然流产#,在中医中,相当于#补阴#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=961300, encodeId=25e296130089, content=收益, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200723/6c985ac9a8b64717b899a2b5931f0ba0/5f40c636aafd4af59cb56b6987ac53e9.jpg, createdBy=6ccc5402354, createdName=ms2000000630457342, createdTime=Wed Apr 28 19:32:40 CST 2021, time=2021-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1907623, encodeId=ade7190e62318, content=<a href='/topic/show?id=379fe3364c9' target=_blank style='color:#2F92EE;'>#研究人员#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73364, encryptionId=379fe3364c9, topicName=研究人员)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db5b227, createdName=gostraight, createdTime=Wed Jul 14 01:38:32 CST 2021, time=2021-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=892556, encodeId=991489255640, content=认真学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=75c55424163, createdName=ms9000001186008086, createdTime=Fri Oct 16 22:12:36 CST 2020, time=2020-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=892010, encodeId=10b2892010dc, content=<a href='/topic/show?id=73a8988297a' target=_blank style='color:#2F92EE;'>#雷帕霉素#</a>可以防止<a href='/topic/show?id=a98786262a1' target=_blank style='color:#2F92EE;'>#自然流产#</a>,在中医中,相当于<a href='/topic/show?id=8f33103968a3' target=_blank style='color:#2F92EE;'>#补阴#</a>?, beContent=null, objectType=article, channel=null, level=null, likeNumber=168, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98829, encryptionId=73a8988297a, topicName=雷帕霉素), TopicDto(id=86262, encryptionId=a98786262a1, topicName=自然流产), TopicDto(id=103968, encryptionId=8f33103968a3, topicName=补阴)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Wed Oct 14 14:14:41 CST 2020, time=2020-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538597, encodeId=044e153859ea0, content=<a href='/topic/show?id=751e42660f1' target=_blank style='color:#2F92EE;'>#复旦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42660, encryptionId=751e42660f1, topicName=复旦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6c312994908, createdName=saikp, createdTime=Mon Oct 12 10:38:32 CST 2020, time=2020-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=891124, encodeId=83bd8911249c, content=<a href='/topic/show?id=b36c652e313' target=_blank style='color:#2F92EE;'>#流产#</a>治疗策略值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65273, encryptionId=b36c652e313, topicName=流产)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Sat Oct 10 19:58:01 CST 2020, time=2020-10-10, status=1, ipAttribution=)]
    2020-10-12 saikp
  6. [GetPortalCommentsPageByObjectIdResponse(id=961300, encodeId=25e296130089, content=收益, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200723/6c985ac9a8b64717b899a2b5931f0ba0/5f40c636aafd4af59cb56b6987ac53e9.jpg, createdBy=6ccc5402354, createdName=ms2000000630457342, createdTime=Wed Apr 28 19:32:40 CST 2021, time=2021-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1907623, encodeId=ade7190e62318, content=<a href='/topic/show?id=379fe3364c9' target=_blank style='color:#2F92EE;'>#研究人员#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73364, encryptionId=379fe3364c9, topicName=研究人员)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=db5b227, createdName=gostraight, createdTime=Wed Jul 14 01:38:32 CST 2021, time=2021-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=892556, encodeId=991489255640, content=认真学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=75c55424163, createdName=ms9000001186008086, createdTime=Fri Oct 16 22:12:36 CST 2020, time=2020-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=892010, encodeId=10b2892010dc, content=<a href='/topic/show?id=73a8988297a' target=_blank style='color:#2F92EE;'>#雷帕霉素#</a>可以防止<a href='/topic/show?id=a98786262a1' target=_blank style='color:#2F92EE;'>#自然流产#</a>,在中医中,相当于<a href='/topic/show?id=8f33103968a3' target=_blank style='color:#2F92EE;'>#补阴#</a>?, beContent=null, objectType=article, channel=null, level=null, likeNumber=168, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98829, encryptionId=73a8988297a, topicName=雷帕霉素), TopicDto(id=86262, encryptionId=a98786262a1, topicName=自然流产), TopicDto(id=103968, encryptionId=8f33103968a3, topicName=补阴)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Wed Oct 14 14:14:41 CST 2020, time=2020-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1538597, encodeId=044e153859ea0, content=<a href='/topic/show?id=751e42660f1' target=_blank style='color:#2F92EE;'>#复旦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42660, encryptionId=751e42660f1, topicName=复旦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e6c312994908, createdName=saikp, createdTime=Mon Oct 12 10:38:32 CST 2020, time=2020-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=891124, encodeId=83bd8911249c, content=<a href='/topic/show?id=b36c652e313' target=_blank style='color:#2F92EE;'>#流产#</a>治疗策略值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=181, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65273, encryptionId=b36c652e313, topicName=流产)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200529/3611e9bb629c4e5b81fbd8ce784b06cc/128487eae357460bb98f67d86230c218.jpg, createdBy=ab235268530, createdName=神盾医疗局局长Jack, createdTime=Sat Oct 10 19:58:01 CST 2020, time=2020-10-10, status=1, ipAttribution=)]
    2020-10-10 神盾医疗局局长Jack

    #流产#治疗策略值得关注

    0

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