J Periodontal Res:苯妥英钠改善牙龈成纤维细胞的老化与自噬相关

2020-05-22 lishiting MedSci原创

这篇研究的目的是为了评估phenytoin对老化牙龈成纤维细胞的作用是否与自噬通路有关。

人牙龈成纤维细胞老化是牙周疾病的一个重要因素。苯妥英钠(phenytoin)具有一定的负作用,它会导致牙龈增生,并且对自噬的进程有一定的影响。这篇研究的目的是为了评估phenytoin对老化牙龈成纤维细胞的作用是否与自噬通路有关。

老化的人牙龈成纤维细胞系HGF-1通过过氧化氢(H2 O2 )诱导形成,并同时施以phenytoin和3-methyladenine (3-MA)刺激。通过流式细胞仪检测细胞活力、细胞周期以及细胞内钙离子的波动。通过RT-PCR、WB和IF染色检测basic fibroblast growth factor (bFGF), P16INK4A , P21cip1和bFGF, P16INK4A , P21cip1 , LC3II, p62和Beclin的表达。

结果显示,H2 O2抑制老化HGF-1的增殖,bFGF, P16INK4A和P21cip1的基因和蛋白表达降低,自噬相关的蛋白LC3II, p62和Becline表达减弱,而G0/G1阶段的比例以及细胞周期的细胞内钙水平增加。Phenytoin能够恢复上述的变化,但是phenytoin的作用会受到3-MA所阻断。

结论:研究表明,phenytoin能够改善H2 O2诱导的牙龈成纤维细胞老化。此种情况与自噬通路的增强相关。

原始出处

Yi Kang, Ruhui Yang, et al. Phenytoin Sodium-Ameliorated Gingival Fibroblast Aging Is Associated With Autophagy. J Periodontal Res., 2020 Apr 12. doi: 10.1111/jre.12750.

 

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    2020-06-08 feather89
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