传染科

订阅

MedSci主页 / 所有栏目 / 传染科

AP&T: 抗TNF治疗可以减轻自身性免疫疾病患者患有COVID-19后的临床症状与结局

2022-01-11 MedSci原创 MedSci原创

(TNF)-α拮抗剂新冠病毒
关注

新冠病毒(COVID-19)在全球大流行,人们对新冠病毒的认识也在不断积累。作为炎症性肠病患者(包括克罗恩病和溃疡性结肠炎,简称IBD患者)也需要特别关注。

感染新冠病毒（COVID-19）的大多数人要么没有症状，要么表现为轻微的症状，包括发烧、咳嗽、肌痛、疲劳、无嗅觉等。然而，有相当一部分感染者有可能发展成严重的疾病，需要住院或进入重症监护室接受治疗。在早期阶段解决新冠病毒（SARS-CoV-2）感染的病人和那些进展到严重疾病状态的病人之间的一个关键区别因素是细胞因子风暴综合征的发展。这是一个炎症过程，即白细胞介素-6（IL-6）、白细胞介素-1（IL-1）和肿瘤坏死因子-α（TNF-α）等促炎性细胞因子似乎是关键因素。炎症性肠病（IBD）和风湿性疾病（RD）患者被认为是免疫力低下的人群，这些患者与感染风险的增加有关，有时结果比普通人群更差。最近，越来越多的研究表明，在IBD和RD患者中，COVID-19引起的不良后果的概率降低与抗TNF药物治疗之间存在关联。本项研究旨在阐明COVID-19与IBD和RD患者使用抗TNF药物治疗之间的关系。

 

研究人员使用特定关键字在 PubMed 和 SCOPUS 数据库中进行了文献系统搜索。将截止到2021年9月接受抗 TNF 治疗的患者的 COVID-19 结果的所有报告纳入本项荟萃分析中。使用随机效应模型计算合并效应量度。观察性研究的纽卡斯尔渥太华量表被用于评估本项研究的偏倚。

 

总共有 84 项研究被纳入系统评价，35 项研究被纳入荟萃分析。研究结果发现与非抗 TNF 治疗相比，在 COVID-19 病例中接受抗 TNF 治疗的患者住院的可能性较低（八项研究，共2555 名患者，OR = 0.53，95% CI：0.42-0.67，I2 = 0 ) ，而且可以降低重症监护病房入院或死亡的发生率（两项研究，共1823 名患者，OR = 0.63，95% CI：0.41-0.96，I2 = 0)。与未接受抗 TNF 治疗的患者相比，接受抗TNF治疗的患者在没有 COVID-19 的人群中因 COVID-19 住院的风险没有差异（三项研究，共5994958 名参与者，OR= 0.97, 95 % CI：0.68-1.39，I2 = 20）。

图：荟萃分析显示抗TNF治疗降低COVID-19的重症发生率

 

本项研究证实与针对潜在炎症性疾病的任何其他治疗方法相比，TNF-α 抑制剂与较低的住院率和严重的 COVID-19 相关。

原始出处：

Georgios Kokkotis. Et al. Systematic review with meta-analysis: COVID-19 outcomes in patients receiving anti-TNF treatments. Alimentary Pharmacology & Therapeutics.2021.

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (7)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1799196, encodeId=96a01e9919605, content=<a href='/topic/show?id=38e0e0670ff' target=_blank style='color:#2F92EE;'>#疾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70670, encryptionId=38e0e0670ff, topicName=疾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Sun Oct 30 04:46:53 CST 2022, time=2022-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1910745, encodeId=6a131910e45a3, content=<a href='/topic/show?id=0934229139c' target=_blank style='color:#2F92EE;'>#临床症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22913, encryptionId=0934229139c, topicName=临床症状)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3860283, createdName=whmdzju, createdTime=Mon Jun 27 04:46:53 CST 2022, time=2022-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1670811, encodeId=425a16e0811c5, content=<a href='/topic/show?id=abd35513ed5' target=_blank style='color:#2F92EE;'>#抗TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55137, encryptionId=abd35513ed5, topicName=抗TNF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7dc326754916, createdName=mfx808, createdTime=Tue Oct 25 20:46:53 CST 2022, time=2022-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2070156, encodeId=cd1820e015602, content=<a href='/topic/show?id=49d25514317' target=_blank style='color:#2F92EE;'>#抗TNF治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55143, encryptionId=49d25514317, topicName=抗TNF治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b05b180, createdName=grace5700, createdTime=Mon Jan 10 15:46:53 CST 2022, time=2022-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1183467, encodeId=08c6118346e6b, content=不错不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4b6d5475252, createdName=ms8000001070895458, createdTime=Wed Jan 12 10:22:30 CST 2022, time=2022-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401806, encodeId=3eee140180666, content=<a href='/topic/show?id=17e21e57943' target=_blank style='color:#2F92EE;'>#TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17579, encryptionId=17e21e57943, topicName=TNF)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqjVbfRD4f4vibEcZVcvato8Qib1gGtZJiayXCMFgHrkeErSiaxdYMiabKGxY2an9muxWCkUJbjFPViaC6A/132, createdBy=e4fb2361580, createdName=snowpeakxu, createdTime=Wed Jan 05 05:46:53 CST 2022, time=2022-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1511265, encodeId=5fdb151126548, content=<a href='/topic/show?id=3f922910088' target=_blank style='color:#2F92EE;'>#免疫疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29100, encryptionId=3f922910088, topicName=免疫疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8a3610309283, createdName=晓辰, createdTime=Wed Jan 05 05:46:53 CST 2022, time=2022-01-05, status=1, ipAttribution=)]
    2022-10-30 hmwwww

    #疾病患者#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1799196, encodeId=96a01e9919605, content=<a href='/topic/show?id=38e0e0670ff' target=_blank style='color:#2F92EE;'>#疾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70670, encryptionId=38e0e0670ff, topicName=疾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Sun Oct 30 04:46:53 CST 2022, time=2022-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1910745, encodeId=6a131910e45a3, content=<a href='/topic/show?id=0934229139c' target=_blank style='color:#2F92EE;'>#临床症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22913, encryptionId=0934229139c, topicName=临床症状)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3860283, createdName=whmdzju, createdTime=Mon Jun 27 04:46:53 CST 2022, time=2022-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1670811, encodeId=425a16e0811c5, content=<a href='/topic/show?id=abd35513ed5' target=_blank style='color:#2F92EE;'>#抗TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55137, encryptionId=abd35513ed5, topicName=抗TNF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7dc326754916, createdName=mfx808, createdTime=Tue Oct 25 20:46:53 CST 2022, time=2022-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2070156, encodeId=cd1820e015602, content=<a href='/topic/show?id=49d25514317' target=_blank style='color:#2F92EE;'>#抗TNF治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55143, encryptionId=49d25514317, topicName=抗TNF治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b05b180, createdName=grace5700, createdTime=Mon Jan 10 15:46:53 CST 2022, time=2022-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1183467, encodeId=08c6118346e6b, content=不错不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4b6d5475252, createdName=ms8000001070895458, createdTime=Wed Jan 12 10:22:30 CST 2022, time=2022-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401806, encodeId=3eee140180666, content=<a href='/topic/show?id=17e21e57943' target=_blank style='color:#2F92EE;'>#TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17579, encryptionId=17e21e57943, topicName=TNF)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqjVbfRD4f4vibEcZVcvato8Qib1gGtZJiayXCMFgHrkeErSiaxdYMiabKGxY2an9muxWCkUJbjFPViaC6A/132, createdBy=e4fb2361580, createdName=snowpeakxu, createdTime=Wed Jan 05 05:46:53 CST 2022, time=2022-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1511265, encodeId=5fdb151126548, content=<a href='/topic/show?id=3f922910088' target=_blank style='color:#2F92EE;'>#免疫疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29100, encryptionId=3f922910088, topicName=免疫疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8a3610309283, createdName=晓辰, createdTime=Wed Jan 05 05:46:53 CST 2022, time=2022-01-05, status=1, ipAttribution=)]
    2022-06-27 whmdzju

    #临床症状#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1799196, encodeId=96a01e9919605, content=<a href='/topic/show?id=38e0e0670ff' target=_blank style='color:#2F92EE;'>#疾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70670, encryptionId=38e0e0670ff, topicName=疾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Sun Oct 30 04:46:53 CST 2022, time=2022-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1910745, encodeId=6a131910e45a3, content=<a href='/topic/show?id=0934229139c' target=_blank style='color:#2F92EE;'>#临床症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22913, encryptionId=0934229139c, topicName=临床症状)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3860283, createdName=whmdzju, createdTime=Mon Jun 27 04:46:53 CST 2022, time=2022-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1670811, encodeId=425a16e0811c5, content=<a href='/topic/show?id=abd35513ed5' target=_blank style='color:#2F92EE;'>#抗TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55137, encryptionId=abd35513ed5, topicName=抗TNF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7dc326754916, createdName=mfx808, createdTime=Tue Oct 25 20:46:53 CST 2022, time=2022-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2070156, encodeId=cd1820e015602, content=<a href='/topic/show?id=49d25514317' target=_blank style='color:#2F92EE;'>#抗TNF治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55143, encryptionId=49d25514317, topicName=抗TNF治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b05b180, createdName=grace5700, createdTime=Mon Jan 10 15:46:53 CST 2022, time=2022-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1183467, encodeId=08c6118346e6b, content=不错不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4b6d5475252, createdName=ms8000001070895458, createdTime=Wed Jan 12 10:22:30 CST 2022, time=2022-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401806, encodeId=3eee140180666, content=<a href='/topic/show?id=17e21e57943' target=_blank style='color:#2F92EE;'>#TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17579, encryptionId=17e21e57943, topicName=TNF)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqjVbfRD4f4vibEcZVcvato8Qib1gGtZJiayXCMFgHrkeErSiaxdYMiabKGxY2an9muxWCkUJbjFPViaC6A/132, createdBy=e4fb2361580, createdName=snowpeakxu, createdTime=Wed Jan 05 05:46:53 CST 2022, time=2022-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1511265, encodeId=5fdb151126548, content=<a href='/topic/show?id=3f922910088' target=_blank style='color:#2F92EE;'>#免疫疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29100, encryptionId=3f922910088, topicName=免疫疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8a3610309283, createdName=晓辰, createdTime=Wed Jan 05 05:46:53 CST 2022, time=2022-01-05, status=1, ipAttribution=)]
    2022-10-25 mfx808

    #抗TNF#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1799196, encodeId=96a01e9919605, content=<a href='/topic/show?id=38e0e0670ff' target=_blank style='color:#2F92EE;'>#疾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70670, encryptionId=38e0e0670ff, topicName=疾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Sun Oct 30 04:46:53 CST 2022, time=2022-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1910745, encodeId=6a131910e45a3, content=<a href='/topic/show?id=0934229139c' target=_blank style='color:#2F92EE;'>#临床症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22913, encryptionId=0934229139c, topicName=临床症状)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3860283, createdName=whmdzju, createdTime=Mon Jun 27 04:46:53 CST 2022, time=2022-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1670811, encodeId=425a16e0811c5, content=<a href='/topic/show?id=abd35513ed5' target=_blank style='color:#2F92EE;'>#抗TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55137, encryptionId=abd35513ed5, topicName=抗TNF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7dc326754916, createdName=mfx808, createdTime=Tue Oct 25 20:46:53 CST 2022, time=2022-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2070156, encodeId=cd1820e015602, content=<a href='/topic/show?id=49d25514317' target=_blank style='color:#2F92EE;'>#抗TNF治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55143, encryptionId=49d25514317, topicName=抗TNF治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b05b180, createdName=grace5700, createdTime=Mon Jan 10 15:46:53 CST 2022, time=2022-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1183467, encodeId=08c6118346e6b, content=不错不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4b6d5475252, createdName=ms8000001070895458, createdTime=Wed Jan 12 10:22:30 CST 2022, time=2022-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401806, encodeId=3eee140180666, content=<a href='/topic/show?id=17e21e57943' target=_blank style='color:#2F92EE;'>#TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17579, encryptionId=17e21e57943, topicName=TNF)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqjVbfRD4f4vibEcZVcvato8Qib1gGtZJiayXCMFgHrkeErSiaxdYMiabKGxY2an9muxWCkUJbjFPViaC6A/132, createdBy=e4fb2361580, createdName=snowpeakxu, createdTime=Wed Jan 05 05:46:53 CST 2022, time=2022-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1511265, encodeId=5fdb151126548, content=<a href='/topic/show?id=3f922910088' target=_blank style='color:#2F92EE;'>#免疫疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29100, encryptionId=3f922910088, topicName=免疫疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8a3610309283, createdName=晓辰, createdTime=Wed Jan 05 05:46:53 CST 2022, time=2022-01-05, status=1, ipAttribution=)]
    2022-01-10 grace5700

    #抗TNF治疗#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1799196, encodeId=96a01e9919605, content=<a href='/topic/show?id=38e0e0670ff' target=_blank style='color:#2F92EE;'>#疾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70670, encryptionId=38e0e0670ff, topicName=疾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Sun Oct 30 04:46:53 CST 2022, time=2022-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1910745, encodeId=6a131910e45a3, content=<a href='/topic/show?id=0934229139c' target=_blank style='color:#2F92EE;'>#临床症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22913, encryptionId=0934229139c, topicName=临床症状)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3860283, createdName=whmdzju, createdTime=Mon Jun 27 04:46:53 CST 2022, time=2022-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1670811, encodeId=425a16e0811c5, content=<a href='/topic/show?id=abd35513ed5' target=_blank style='color:#2F92EE;'>#抗TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55137, encryptionId=abd35513ed5, topicName=抗TNF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7dc326754916, createdName=mfx808, createdTime=Tue Oct 25 20:46:53 CST 2022, time=2022-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2070156, encodeId=cd1820e015602, content=<a href='/topic/show?id=49d25514317' target=_blank style='color:#2F92EE;'>#抗TNF治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55143, encryptionId=49d25514317, topicName=抗TNF治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b05b180, createdName=grace5700, createdTime=Mon Jan 10 15:46:53 CST 2022, time=2022-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1183467, encodeId=08c6118346e6b, content=不错不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4b6d5475252, createdName=ms8000001070895458, createdTime=Wed Jan 12 10:22:30 CST 2022, time=2022-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401806, encodeId=3eee140180666, content=<a href='/topic/show?id=17e21e57943' target=_blank style='color:#2F92EE;'>#TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17579, encryptionId=17e21e57943, topicName=TNF)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqjVbfRD4f4vibEcZVcvato8Qib1gGtZJiayXCMFgHrkeErSiaxdYMiabKGxY2an9muxWCkUJbjFPViaC6A/132, createdBy=e4fb2361580, createdName=snowpeakxu, createdTime=Wed Jan 05 05:46:53 CST 2022, time=2022-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1511265, encodeId=5fdb151126548, content=<a href='/topic/show?id=3f922910088' target=_blank style='color:#2F92EE;'>#免疫疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29100, encryptionId=3f922910088, topicName=免疫疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8a3610309283, createdName=晓辰, createdTime=Wed Jan 05 05:46:53 CST 2022, time=2022-01-05, status=1, ipAttribution=)]
    2022-01-12 ms8000001070895458

    不错不错

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1799196, encodeId=96a01e9919605, content=<a href='/topic/show?id=38e0e0670ff' target=_blank style='color:#2F92EE;'>#疾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70670, encryptionId=38e0e0670ff, topicName=疾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Sun Oct 30 04:46:53 CST 2022, time=2022-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1910745, encodeId=6a131910e45a3, content=<a href='/topic/show?id=0934229139c' target=_blank style='color:#2F92EE;'>#临床症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22913, encryptionId=0934229139c, topicName=临床症状)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3860283, createdName=whmdzju, createdTime=Mon Jun 27 04:46:53 CST 2022, time=2022-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1670811, encodeId=425a16e0811c5, content=<a href='/topic/show?id=abd35513ed5' target=_blank style='color:#2F92EE;'>#抗TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55137, encryptionId=abd35513ed5, topicName=抗TNF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7dc326754916, createdName=mfx808, createdTime=Tue Oct 25 20:46:53 CST 2022, time=2022-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2070156, encodeId=cd1820e015602, content=<a href='/topic/show?id=49d25514317' target=_blank style='color:#2F92EE;'>#抗TNF治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55143, encryptionId=49d25514317, topicName=抗TNF治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b05b180, createdName=grace5700, createdTime=Mon Jan 10 15:46:53 CST 2022, time=2022-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1183467, encodeId=08c6118346e6b, content=不错不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4b6d5475252, createdName=ms8000001070895458, createdTime=Wed Jan 12 10:22:30 CST 2022, time=2022-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401806, encodeId=3eee140180666, content=<a href='/topic/show?id=17e21e57943' target=_blank style='color:#2F92EE;'>#TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17579, encryptionId=17e21e57943, topicName=TNF)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqjVbfRD4f4vibEcZVcvato8Qib1gGtZJiayXCMFgHrkeErSiaxdYMiabKGxY2an9muxWCkUJbjFPViaC6A/132, createdBy=e4fb2361580, createdName=snowpeakxu, createdTime=Wed Jan 05 05:46:53 CST 2022, time=2022-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1511265, encodeId=5fdb151126548, content=<a href='/topic/show?id=3f922910088' target=_blank style='color:#2F92EE;'>#免疫疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29100, encryptionId=3f922910088, topicName=免疫疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8a3610309283, createdName=晓辰, createdTime=Wed Jan 05 05:46:53 CST 2022, time=2022-01-05, status=1, ipAttribution=)]
    2022-01-05 snowpeakxu

    #TNF#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1799196, encodeId=96a01e9919605, content=<a href='/topic/show?id=38e0e0670ff' target=_blank style='color:#2F92EE;'>#疾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70670, encryptionId=38e0e0670ff, topicName=疾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Sun Oct 30 04:46:53 CST 2022, time=2022-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1910745, encodeId=6a131910e45a3, content=<a href='/topic/show?id=0934229139c' target=_blank style='color:#2F92EE;'>#临床症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22913, encryptionId=0934229139c, topicName=临床症状)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3860283, createdName=whmdzju, createdTime=Mon Jun 27 04:46:53 CST 2022, time=2022-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1670811, encodeId=425a16e0811c5, content=<a href='/topic/show?id=abd35513ed5' target=_blank style='color:#2F92EE;'>#抗TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55137, encryptionId=abd35513ed5, topicName=抗TNF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7dc326754916, createdName=mfx808, createdTime=Tue Oct 25 20:46:53 CST 2022, time=2022-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2070156, encodeId=cd1820e015602, content=<a href='/topic/show?id=49d25514317' target=_blank style='color:#2F92EE;'>#抗TNF治疗#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55143, encryptionId=49d25514317, topicName=抗TNF治疗)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b05b180, createdName=grace5700, createdTime=Mon Jan 10 15:46:53 CST 2022, time=2022-01-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1183467, encodeId=08c6118346e6b, content=不错不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4b6d5475252, createdName=ms8000001070895458, createdTime=Wed Jan 12 10:22:30 CST 2022, time=2022-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401806, encodeId=3eee140180666, content=<a href='/topic/show?id=17e21e57943' target=_blank style='color:#2F92EE;'>#TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17579, encryptionId=17e21e57943, topicName=TNF)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqjVbfRD4f4vibEcZVcvato8Qib1gGtZJiayXCMFgHrkeErSiaxdYMiabKGxY2an9muxWCkUJbjFPViaC6A/132, createdBy=e4fb2361580, createdName=snowpeakxu, createdTime=Wed Jan 05 05:46:53 CST 2022, time=2022-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1511265, encodeId=5fdb151126548, content=<a href='/topic/show?id=3f922910088' target=_blank style='color:#2F92EE;'>#免疫疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29100, encryptionId=3f922910088, topicName=免疫疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8a3610309283, createdName=晓辰, createdTime=Wed Jan 05 05:46:53 CST 2022, time=2022-01-05, status=1, ipAttribution=)]
    2022-01-05 晓辰

    #免疫疾病#

    0